Results 71 to 80 of about 67,993 (297)

A Dual‐Bioresponsive and Programmable Microneedle Matrix as a Bioinspired Coupler for Orchestrating Diabetic Bone Regeneration

Advanced Materials, EarlyView.
This project developed a smart bandage‐like patch (a microneedle array) for repairing diabetic bone damage. It intelligently senses signals from infection and inflammation, then releases its medicines in a specific, timed sequence: first an antibacterial agent, then an anti‐inflammatory agent, and finally growth factors.
Yu Wang, Rui Chen, Yu Chen, Haowen Lu, Yuchen Qian, Zhiheng Gao, Zheming Shen, Xiaofei Zheng, Huilin Yang, Jun Zou, Yusen Qiao   +10 more
wiley   +1 more source

Qualitative and quantitative studies on two commercial specifications of Polygonatum odoratum

Frontiers in Chemistry, 2023
The rhizoma of Polygonatum odoratum (PO) is used to treat yin injuries of the lung and stomach in traditional Chinese medicine. The chemical constituents of this herb are steroidal saponins, homoisoflavanones, and alkaloids.
Yi Nan, Yi Nan, Haizhen Liang, Xu Pang, Wei Zheng, Yuhao Shi, Yuhao Shi, Xiaojuan Chen, Jie Zhang, Juan Song, Baiping Ma, Baiping Ma   +11 more
doaj   +1 more source

Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Application of chromatographic methods for quality control of cannabinoid impurities in products containing Cannabidiol [PDF]

Pharmacia
Strict quality control of impurities in legitimate cannabidiol products and in cannabis “novel foods” is necessary due to the increased health risks from side effects associated with these impurities.
Dobrina Tsvetkova, Ivanka Pencheva, Lily Peikova   +2 more
doaj   +3 more sources

Raw data for UHPLC-HRMS [PDF]

, 2023
This dataset contains the raw data of UHPLC-HRMS for intestine-absorbing chemical compounds in TCM CHQY granules at both positive and negative models.
Zhi Li (16820535), Honglian Wang (6874745)   +1 more
core   +1 more source

Climate Change Threatens Micronutrient Density of European Winter Wheat

Advanced Science, EarlyView.
Micronutrients are vital for human health. Wheat is a major staple crop and a significant source of minerals and B‐vitamins. The impact of climate change on their content remains largely unknown. We evaluated micronutrient levels in European winter wheat grown under historical and projected climate conditions. Our findings indicate that future climates
Da Cao, Jennifer Michel, Eline Lorer, Markus Weinmann, Jacques Le Gouis, Claire Léon, Sibille Perrochon, David Alvarez, Vincent Leemans, Iñaki Balanzategui Guijarro, Jordi Moya Laraño, Sara Sánchez Moreno, Symanczik Sarah, Waibel Matthias, Hervé Vanderschuren, Cécile Thonar, Pierre Delaplace, Dominique Van Der Straeten   +17 more
wiley   +1 more source

Classification and Authentication of Paprika by UHPLC-HRMS Fingerprinting and Multivariate Calibration Methods (PCA and PLS-DA)

Foods, 2020
In this study, the feasibility of non-targeted UHPLC-HRMS fingerprints as chemical descriptors to address the classification and authentication of paprika samples was evaluated.
Sergio Barbosa, Javier Saurina, Lluís Puignou, Oscar Núñez   +3 more
doaj   +1 more source

A universal UHPLC-CAD platform for the quantification of polysaccharide antigens

Scientific Reports, 2023
Several glycoconjugate-based vaccines against bacterial infections have been developed and licensed for human use. Polysaccharide (PS) analysis and characterization is therefore critical to profile the composition of polysaccharide-based vaccines. For PS
A. Corrado, M. De Martino, V. Bordoni, S. Giannini, F. Rech, S. Cianetti, F. Berti, C. Magagnoli, R. De Ricco   +8 more
doaj   +1 more source

Zinc Exposure Causes Disulfidptosis to Induce Miscarriage by Up‐Regulating GATA1/METTL1/SLC7A11 Axis

Advanced Science, EarlyView.
Zn exposure up‐regulates GATA1, promoting GATA1‐mediated METTL1 and SLC7A11 transcription. It also enhances METTL1‐mediated m7G modification on SLC7A11 mRNA, increasing SLC7A11 mRNA stability. Ultimately, Zn exposure up‐regulates SLC7A11 at both transcriptional and post‐transcriptional levels, causing disulfidptosis. Knockdown of murine Slc7a11, Gata1,
Wenxin Huang, Yi Sun, Yanxin Wang, Haijun Yan, Xiaoping Yue, Weidong Wu, Xueyu Chen, Jinfang Zhang, Yanbing Lin, Qiong Lei, Nan Ji, Shuaishuai Xing, Liqin Zeng, Qingzheng Kang, Depeng Zhao, Geng Guo, Huidong Zhang   +16 more
wiley   +1 more source

Plasma sample preraration in untargeted metabonomics studies by UHPLC/TOF-MS [PDF]

, 2010
Plasma sample preraration in untargeted metabonomics studies by UHPLC/TOF ...
许国旺, WormannK., FeketeA., LehmannR., Forcisi S., ForcisiS., Schmitt-KopplinP.   +6 more
core