Results 101 to 110 of about 558,447 (316)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Media information UK 1983

open access: yes, 1983
SIGLELD:5525.25817(1983) / BLDSC - British Library Document Supply CentreGBUnited ...
Media Information Ltd., London (UK)
core  

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Media Reporting and Public Knowledge, 2007

open access: yes, 2008
copyright UK Data Service and data collection copyright owner.This project investigates the consequences of the shift from hard to soft news, and from international to domestic news, in the media, and the effect that this shift is having on public ...
Curran, J., University of London, Goldsmiths College, Department of Media and Communications
core  

Modelling Timbral Hardness

open access: yesApplied Sciences, 2019
Hardness is the most commonly searched timbral attribute within freesound.org, a commonly used online sound effect repository. A perceptual model of hardness was developed to enable the automatic generation of metadata to facilitate hardness-based ...
Andy Pearce, Tim Brookes, Russell Mason
doaj   +1 more source

Digital media and networks of Hindu activism in the UK

open access: yesCulture and Religion, 2015
This paper seeks to explore the role of digital media and other forms of networking in the development of Hindu activism in a diaspora environment. It asks how the opening up and development of new digital media environments has impacted on Hindu activism, its potential for growth and its resonance in broader social and political spaces.
openaire   +3 more sources

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Social media, higher-risk consumption, and brand identification [PDF]

open access: yes, 2019
Aim: To explore participation with alcohol marketing (i.e. commenting on brand statuses) and user-created promotion on social media (i.e. photos of peers drinking) by young people in the United Kingdom (UK), and what association this has with higher-risk
Nathan Critchlow (6375536)   +9 more
core   +1 more source

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