Results 91 to 100 of about 26,714,216 (288)

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

A Doctrinal and Newspaper Data Analysis of UK Policy for LGBTQ+ Asylum Seekers Following the Enactment of the Nationality and Boarders Act 2022

Societies
The UK government has detailed guidelines for assessing and guiding LGBTQI+ asylum seekers through the asylum process in the UK. This is an explorative paper assessing whether post the enactment of the Nationalities and Boarders Act 2022 the media ...
Rachel Saunders
doaj   +1 more source

Reactions of industry and associated organisations to the announcement of the UK Soft Drinks Industry Levy: longitudinal thematic analysis of UK media articles, 2016-18. [PDF]

BMC Public Health, 2023
Penney TL, Jones CP, Pell D, Cummins S, Adams J, Forde H, Mytton O, Rutter H, Smith R, White M.   +9 more
europepmc   +1 more source

GelMA‐based 3D spheroids recapitulate transcriptomic and functional hallmarks of myeloid sarcoma

FEBS Open Bio, EarlyView.
GelMA 5% hydrogels support the formation of myeloid leukemia spheroids that recapitulate MS‐specific features, including G1 arrest, apoptosis, and ECM‐driven transcriptomic reprogramming. The 3D model mimicked soft‐tissue‐like stiffness and oxygen conditions, and transcriptomic convergence with primary MS samples confirmed its utility as a preclinical ...
Nicolas Germain, Elise Buret, Le Hoang Thanh Nguyen, Marion Cocheteux, Nicolas Touya, Mélanie Dhayer, Romain Dubois, Frank Lafont, Sebastien Janel, Patrice Maboudou, Steve Lancel, Philippe Marchetti   +11 more
wiley   +1 more source

'From disaster, miracles are wrought': a narrative analysis of UK media depictions of remote GP consulting in the COVID-19 pandemic using Burke's pentad. [PDF]

Med Humanit, 2021
Mroz G, Papoutsi C, Greenhalgh T.
europepmc   +1 more source

Digital media and networks of Hindu activism in the UK

Culture and Religion, 2015
This paper seeks to explore the role of digital media and other forms of networking in the development of Hindu activism in a diaspora environment. It asks how the opening up and development of new digital media environments has impacted on Hindu activism, its potential for growth and its resonance in broader social and political spaces.
openaire   +2 more sources

Structural and biochemical insights into the thermostable esterase Ta0887 from Thermoplasma acidophilum

FEBS Open Bio, EarlyView.
In this study, a novel esterase from the thermoacidophilic archaeon Thermoplasma acidophilum was biochemically and structurally characterized. Our results demonstrate that Ta0887 is a highly thermostable esterase that preferentially hydrolyzes p‐nitrophenyl hexanoate and possesses an α‐helical cap domain that likely contributes to its substrate ...
Alejandro Delgado‐Rey, Miriam Livier Llamas‐García, Gabriela M. Montero‐Morán, Leticia Santos, Samuel Lara‐González   +4 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Exploring health literacy in developing economies: Perspectives and practices of health communication professionals in rural Nigeria

Health Literacy and Communication Open
Background Health literacy is widely recognised as a social determinant of health and a key factor in health communication and education, with low health literacy correlated with poor health outcomes and socioeconomic inequalities.
Onyinye Chiweta-Oduah, Steven Buchanan
doaj   +1 more source

Modelling Timbral Hardness

Applied Sciences, 2019
Hardness is the most commonly searched timbral attribute within freesound.org, a commonly used online sound effect repository. A perceptual model of hardness was developed to enable the automatic generation of metadata to facilitate hardness-based ...
Andy Pearce, Tim Brookes, Russell Mason
doaj   +1 more source