Results 71 to 80 of about 558,447 (316)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Securing the Future of UK Public-Interest News: Navigating Change With Foresight and Innovation

Media and Communication
This article delves into the factors driving change in the UK’s public-interest news sector, pinpointing key uncertainties that shape its future. Through a participatory action research approach and scenario planning, the study News Futures 2035, seeks ...
François Nel, Kamila Rymajdo
doaj   +1 more source

Engaging with ethics in Internet of Things: Imaginaries in the social milieu of technology developers

Big Data & Society, 2019
Discussions about ethics of Big Data often focus on the ethics of data processing: collecting, storing, handling, analysing and sharing data. Data-based systems, however, do not come from nowhere.
Funda Ustek-Spilda, Alison Powell, Selena Nemorin   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Machine Learning Approach to Personality Type Prediction Based on the Myers–Briggs Type Indicator^®

Multimodal Technologies and Interaction, 2020
Neuro Linguistic Programming (NLP) is a collection of techniques for personality development. Meta programmes, which are habitual ways of inputting, sorting and filtering the information found in the world around us, are a vital factor in NLP ...
Mohammad Hossein Amirhosseini, Hassan Kazemian   +1 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Cost-effectiveness of a radio intervention to stimulate early childhood development: protocol for an economic evaluation of the SUNRISE trial in Burkina Faso

BMJ Open
Introduction Approximately 250 million children under 5 years of age are at risk of poor development in low-income and middle-income countries. However, existing early childhood development (ECD) interventions can be expensive, labour intensive and ...
Betty Kirkwood, Zelee Hill, Alexander Manu, Jolene Skordis, Tom Palmer, Pasco Fearon, Roy Head, Abbie Clare, Bassirou Kagone   +8 more
doaj   +1 more source

Introduction to Special Theme Veillance and transparency: A critical examination of mutual watching in the post-Snowden, Big Data era

Big Data & Society, 2017
Introducing the Special Theme on Veillance and Transparency: A Critical Examination of Mutual Watching in the Post-Snowden, Big Data Era, this article presents a series of provocations and practices on veillance and transparency in the context of Big ...
Vian Bakir, Martina Feilzer, Andrew McStay   +2 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Use of Social Media by UK Local Resilience Forums

, 2014
The potential uses of social media in the field of emergency preparedness, resilience and response (EPRR) are varied and interesting. The UK government have produced guidance documents for its use in the UK EPRR field but evidence of use is poorly ...
Meaton, Julia, Stringer, Lisa
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