Results 71 to 80 of about 26,714,216 (288)
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Media and CommunicationThe Covid-19 pandemic brought unprecedented challenges to global public health, economies, and societies. In the UK, the impact of Covid-19 on the economy, healthcare systems, and individual well-being was also profound and multifaceted.
Sarah Q. Gong, Ian Somerville
doaj +1 more source
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
Molecular Oncology, EarlyView.This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan +8 more
wiley +1 more source
Big Data & Society, 2017 Introducing the Special Theme on Veillance and Transparency: A Critical Examination of Mutual Watching in the Post-Snowden, Big Data Era, this article presents a series of provocations and practices on veillance and transparency in the context of Big ...
Vian Bakir +2 more
doaj +1 more source
Machine Learning Approach to Personality Type Prediction Based on the Myers–Briggs Type Indicator®
Multimodal Technologies and Interaction, 2020 Neuro Linguistic Programming (NLP) is a collection of techniques for personality development. Meta programmes, which are habitual ways of inputting, sorting and filtering the information found in the world around us, are a vital factor in NLP ...
Mohammad Hossein Amirhosseini +1 more
doaj +1 more source
USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival
Molecular Oncology, EarlyView.CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna +8 more
wiley +1 more source
South African Media and Politics: Is the Three Models Approach Still Valid After Two Decades?
Media and CommunicationWhen Hallin and Mancini (2004) produced their watershed three models theory, South Africa was a new democracy barely a decade old. Even then, along with other countries of the Global South, the experience of a young democracy posed certain critical ...
Bernadine Jones, Adrian Hadland
doaj +1 more source
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
BMJ OpenIntroduction Approximately 250 million children under 5 years of age are at risk of poor development in low-income and middle-income countries. However, existing early childhood development (ECD) interventions can be expensive, labour intensive and ...
Betty Kirkwood +8 more
doaj +1 more source