Results 61 to 70 of about 26,714,216 (288)

Statistical and Multivariate Analysis of the IoT-23 Dataset: A Comprehensive Approach to Network Traffic Pattern Discovery

Journal of Cybersecurity and Privacy
The rapid expansion of Internet of Things (IoT) technologies has introduced significant challenges in understanding the complexity and structure of network traffic data, which is essential for developing effective cybersecurity solutions.
Humera Ghani, Shahram Salekzamankhani, Bal Virdee   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

CFD Simulations and Phenomenological Modelling of Aerodynamic Stall Hysteresis of NACA 0018 Wing

Aerospace
Computational simulations of three-dimensional flow around a NACA 0018 wing with an aspect ratio of AR=5 were carried out by using the Unsteady Reynolds-Averaged Navier–Stokes (URANS) equations with the Shear-Stress Transport turbulence model closure ...
Mohamed Sereez, Nikolay Abramov, Mikhail Goman   +2 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Engaging with ethics in Internet of Things: Imaginaries in the social milieu of technology developers

Big Data & Society, 2019
Discussions about ethics of Big Data often focus on the ethics of data processing: collecting, storing, handling, analysing and sharing data. Data-based systems, however, do not come from nowhere.
Funda Ustek-Spilda, Alison Powell, Selena Nemorin   +2 more
doaj   +1 more source

Pedagogical Uses of Digital Technologies by Pre and In-Service Teachers: Literature Review from a Global Perspective to the Chilean Context

Proceedings, 2018
The broad integration of information and communication technologies (ICT) in students’ and teachers’ lives requires education professionals to think of new ways to provide teaching and learning opportunities.
Angela Novoa-Echaurren, Alejandra Canales-Tapia   +1 more
doaj   +1 more source

The Media and the UK Supreme Court

Cambridge Journal of International and Comparative Law, 2012
The Supreme Court is understandably pleased with the “close relationship with media organisations”1 that its five-person communications team has built up over the past couple of years. In the Court’s annual report for 2010/11, it describes two television documentaries broadcast on minority channels as the “highlight of this year”.2 These programmes ...
openaire   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Securing the Future of UK Public-Interest News: Navigating Change With Foresight and Innovation

Media and Communication
This article delves into the factors driving change in the UK’s public-interest news sector, pinpointing key uncertainties that shape its future. Through a participatory action research approach and scenario planning, the study News Futures 2035, seeks ...
François Nel, Kamila Rymajdo
doaj   +1 more source