Results 131 to 140 of about 1,175 (172)
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Ulipristal acetate as an emergency contraceptive agent
Expert Opinion on Pharmacotherapy, 2012Emergency contraceptive agents play a crucial role in preventing unplanned pregnancy. These agents and devices have been studied since the 1960s and have had varied results in terms of side effects and efficacy. A new oral tablet for emergency contraception (EC), ulipristal acetate (UPA) , is a selective progesterone receptor modulator and can be used ...
Alan M, Martinez, Michael A, Thomas
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Ulipristal acetate: a new emergency contraceptive
Expert Review of Clinical Pharmacology, 2011Ulipristal acetate (UPA) is a newly developed emergency contraceptive currently available in the USA and Europe. It is approved as a 30 mg one-time dose taken within 120 h (5 days) of unprotected intercourse or failed contraception. This selective progesterone receptor modulator appears to be more effective than the levonorgestrel-containing emergency ...
Jade L, Sullivan, Marilyn N, Bulloch
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Ulipristal Acetate: The Newest Emergency Contraceptive
Nursing for Women's Health, 2012More than 50 percent of pregnancies in the United States are unplanned. Emergency contraception has been shown to possibly reduce the risk of pregnancy by as much as 75 percent. Ulipristal acetate is a selective progesterone receptor modulator that was approved by the U.S.
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Ulipristal Acetate: A Review in Symptomatic Uterine Fibroids
Drugs, 2017Oral ulipristal acetate (Esmya®; Fibristal®), a synthetic selective progesterone receptor modulator, is the first selective progesterone modulator to be approved for the treatment of uterine fibroids. It was initially approved for the preoperative treatment of moderate to severe uterine fibroid symptoms in women of reproductive age.
Karly P, Garnock-Jones, Sean T, Duggan
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Ulipristal acetate (Esmya): restrictions on use
Drug and Therapeutics Bulletin, 2018Safety alert: Esmya (ulipristal acetate) for symptoms of uterine fibroids: restrictions to use and requirement to check liver function before, during and after treatment.1,2
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Effect of exposure to ulipristal acetate on sperm function
The European Journal of Contraception & Reproductive Health Care, 2012A pill containing ulipristal acetate (UPA) is used for emergency contraception (EC). Considering that, following its intake, spermatozoa may be exposed to UPA in the female genital tract we intended to evaluate sperm functions after incubation with this compound.Motile spermatozoa were selected by swim-up and were incubated under capacitating ...
María José, Munuce +5 more
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A simple and convenient synthetic route to Ulipristal acetate
Steroids, 2013We set out to describe a new and efficient route for preparing Ulipristal acetate with a good yield. The selected epoxidization conditions gave out 80% of 5α,10α-epoxide 2a in the two diastereoisomers which greatly improved the yield of 11β-substituted isomer 4a.
Yongguo, Yu +4 more
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A new and efficient method for the synthesis of Ulipristal acetate
Steroids, 2014In this study, we describe another new and efficient route for preparing Ulipristal acetate. The 1,4-addition compound 5 was greatly improved after the starting material ketone 1 was underwent epoxidation, cyanation, hydroxyl group protection and Grignard addition.
Xu, Cheng +5 more
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Ulipristal acetate in emergency contraception: mechanism of action
Trends in Pharmacological Sciences, 2013We would like to discuss the mechanism of action of ulipristal acetate (UPA, marketed as ellaOne®), an orally active selective progesterone receptor modulator (SPRM) licensed for emergency contraception (EC). Each tablet contains micronized UPA 30 mg (equivalent to unmicronized UPA 50 mg) [1] and it is effective up to 120 h after unprotected ...
MOZZANEGA, BRUNO +2 more
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First synthesis and characterization for the stereoisomers of Ulipristal acetate
Steroids, 2015The three stereoisomers, 11α,17α-isomer I, 11α,17β-isomer II and 11β,17β-isomer III are related substances of the selective progesterone receptor modulator Ulipristal acetate. Herein, we presented an efficient and practical synthesis approach to deliver these three stereoisomers for the first time, and also confirmed the structure of the key ...
Yi, Zhao +6 more
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