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Ulipristal Acetate for Emergency Contraception
OBJECTIVE: To review the pharmacology, pharmacokinetics, efficacy, and safety of data of ulipristal acetate, a new emergency contraceptive approved for use up to 120 hours after unprotected intercourse. DATA SOURCES: Articles ...
Sara E, Snow +2 more
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Ulipristal Acetate: Contraceptive or Contragestive?
Ulipristal acetate is the first selective progesterone receptor modulator approved for postcoital contraception in the US. It appears to be significantly more effective in inhibition of ovulation than other forms of emergency contraception. However, ulipristal acetate is structurally similar to mifepristone, and several lines of evidence suggest that a
Jeffrey A Keenan
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First synthesis and characterization for the stereoisomers of Ulipristal acetate
Steroids, 2015The three stereoisomers, 11α,17α-isomer I, 11α,17β-isomer II and 11β,17β-isomer III are related substances of the selective progesterone receptor modulator Ulipristal acetate. Herein, we presented an efficient and practical synthesis approach to deliver these three stereoisomers for the first time, and also confirmed the structure of the key ...
Yi Zhao, Yongguo Yu, Yong Wu
exaly +3 more sources
Endometrial changes during ulipristal acetate use: A systematic review
Ulipristal acetate is increasingly used for several clinical indications, like emergency contraception and pre-treatment of uterine fibroids. It has mixed progesterone agonist and antagonist effects in the myometrium and endometrium.
Inge de Milliano +2 more
exaly +2 more sources
Long-term medical management of uterine fibroids with ulipristal acetate [PDF]
Objective To investigate the efficacy and safety of repeated 12-week courses of 5 or 10 mg daily ulipristal acetate for intermittent treatment of symptomatic uterine fibroids.
Hervé Fernández +2 more
exaly +3 more sources
Efficacy and safety of repeated use of ulipristal acetate in uterine fibroids [PDF]
OBJECTIVE: To investigate the efficacy and safety of repeated 12-week courses of 5 or 10 mg daily of ulipristal acetate for intermittent treatment of symptomatic uterine fibroids.
Hervé Fernández +2 more
exaly +3 more sources
Ulipristal acetate for emergency contraception
Drugs of Today, 2010Ulipristal acetate is a progesterone receptor modulator. As an emergency contraceptive, a 30-mg micronized formulation is effective for use up to 120 h from unprotected sexual intercourse. Ulipristal acetate acts as an antagonist of the progesterone receptor at the transcriptional level and a competitive antagonist of glucocorticoid receptor function ...
J A, Russo, M D, Creinin
+5 more sources
To assess the usefulness of 3-month treatment with ulipristal acetate (UPA) before laparoscopic myomectomy of large uterine ...
Umberto Leone Roberti Maggiore +2 more
exaly +2 more sources

