Results 51 to 60 of about 231,179 (296)

Ultra-high field MRI: looking through the 'macroscope' [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2013
The first publications about in vivo application of ultra-high field MRI in multiple sclerosis (MS) appeared in 2008. From then on, the number of studies performed at 7 Tesla (T) has rapidly increased. The main advantage of ultra-high field MRI is its higher signal-to-noise ratio, which can be used to increase spatial resolution greatly.
Kilsdonk, I.D., Wattjes, M.P., Geurts, J.J.G.   +2 more
openaire   +2 more sources

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Super-Resolution for Ultra High-Field MR Images

, 2022
Segmenting ultra high-field MR images is an important first step in many applications. Segmentation methods based on machine learning have been shown to be valuable tools for this purpose.
Lindig, T., Steiglechner, J., Bender, B., Scheffler, K. ; https://orcid.org/, Lohmann, G. ; https://orcid.org/, Wang, Q. ; https://orcid.org/   +5 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Enhancement of transmit and receive efficiencies with hybridized meta-atom in 7T head coil

, 2019
International audienceBackground B1 homogeneity in 7T MRI remains an important challenge in order to fully benefit from the signal enhancement due to the stronger magnetization available in ultra-high field scanners.
Dubois, Marc, Larrat, Benoît, Bonod, Nicolas, Le Bihan, Denis, Raolison, Zo, Sabouroux, Pierre, Georget, Elodie, de Rosny, Julien, Amadon, Alexis, Abdeddaim, Redha, Antonakakis, Tryfon, Poupon, Cyril, Vignaud, Alexandre, Leroi, Lisa, Mauconduit, Franck, Enoch, Stefan, Tayeb, Gérard   +16 more
core   +2 more sources

Ultra-high-field MR in Prostate cancer: Feasibility and Potential

Magnetic Resonance Materials in Physics, Biology and Medicine, 2022
AbstractMultiparametric MRI of the prostate at clinical magnetic field strengths (1.5/3 Tesla) has emerged as a reliable noninvasive imaging modality for identifying clinically significant cancer, enabling selective sampling of high-risk regions with MRI-targeted biopsies, and enabling minimally invasive focal treatment options.
Carlijn J. A. Tenbergen, Gregory J. Metzger, Tom W. J. Scheenen   +2 more
openaire   +4 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A simple and effective method for identifying the real sources of pre-pulses in CPA and OPCPA laser systems

High Power Laser Science and Engineering
The delay-shift of the pre-pulse may mislead the determination of its origination and cause problems for the temporal contrast improvement of high-peak-power lasers, especially when the corresponding post-pulse is beyond the time window of the ...
Haidong Chen, Xun Chen, Xingyan Liu, Jiabing Hu, Peile Bai, Jiayan Gui, Xiaojun Yang, Kegui Xia, Fenxiang Wu, Zongxin Zhang, Yanqi Liu, Xinliang Wang, Yi Xu, Yuxin Leng   +13 more
doaj   +1 more source