Results 71 to 80 of about 231,179 (296)

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Femtosecond laser filament guided negative coronas

AIP Advances, 2020
We report on the experimental investigation of femtosecond laser filament guided negative coronas. When the coupling between the filament and negative corona was weak, the side fluorescence spectral analysis confirmed the existence of impact ionization ...
Tie-Jun Wang, Jianhao Zhang, Zhongbin Zhu, Yaoxiang Liu, Na Chen, Hao Guo, Haiyi Sun, Yuxin Leng, See Leang Chin, Ruxin Li   +9 more
doaj   +1 more source

Ultra-high field magnetic resonance imaging of the basal ganglia and related structures [PDF]

, 2014
Deep brain stimulation is a treatment for Parkinson’s disease and other related disorders, involving the surgical placement of electrodes in the deeply situated basal ganglia or thalamic structures.
Uludag, K., Ivanov, D., Dimo eIvanov, Mark L. Kuijf, Roebroeck, Alard F, Birgit Renske Plantinga, ter Haar Romeny, B.M., Plantinga, BR Birgit, Ter Haar Romenij, B.M., Plantinga, B.R., Roebroeck, A., Alard Roebroeck, Uludağ, Kâmil, Alard eRoebroeck, Yasin eTemel, Kuijf, M.L., Kâmil eUludağ, Kâmil UludaÄŸ, Dimo Ivanov, Temel, Yasin, Haar Romeny, BM Bart ter, Mark Laurens Kuijf, Bart M. ter Haar Romenij, Kuijf, ML Mark, Birgit R. Plantinga, Yasin Temel, Ivanov, D Dimo, Bart eTer Haar Romeny, Temel, Y.   +28 more
core   +1 more source

Ultra-high-field MRI using composite RF (STEP) pulses

, 2021
Ultra-high field MRI offers many opportunities to expand the applications of MRI. In order for this to be realized, the technical problems associated with MRI at field strengths of 7 T and greater need to be solved or mitigated.
Farquharson, S, Ordidge, R, Moffat, B, Cleary, J, Glarin, R, Blunck, Y   +5 more
core   +1 more source

Effect of terahertz irradiation on DNA damage repair in living cells

FEBS Open Bio, EarlyView.
We investigated the effect of terahertz (THz) wave irradiation on DNA double‐strand break (DSB) repair in living cells. We found that THz irradiation enhanced DSB repair at specific frequencies, whereas heat treatment inhibited it, indicating that this effect is nonthermal and frequency‐specific.
Yuya Ueno, Shota Yamazaki, Hiromichi Hoshina, Masahiko Harata   +3 more
wiley   +1 more source

Radiofrequency coil for routine ultra‐high‐field imaging with an unobstructed visual field

NMR in Biomedicine, 2020
Many neuroscience applications have adopted functional MRI as a tool to investigate the healthy and diseased brain during the completion of a task. While ultra‐high‐field MRI has allowed for improved contrast and signal‐to‐noise ratios during functional MRI studies, it remains a challenge to create local radiofrequency coils that can accommodate an ...
Kyle M. Gilbert, L. Martyn Klassen, Alexander Mashkovtsev, Peter Zeman, Ravi S. Menon, Joseph S. Gati   +5 more
openaire   +4 more sources

Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy

FEBS Open Bio, EarlyView.
This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan, Ikram A. Burney, Shika Hanif Malgundkar, Siva Ramamoorthy, Ressin Varghese, Mohamed A. Al‐Kindi, Hamad Al Riyami, Shadia Al Bahlani, Sergey Dobretsov, Syed Imran Hassan, Benjamin K. Tsang, Yahya Tamimi   +11 more
wiley   +1 more source

Complementarity of Long‐Reads and Optical Mapping in Parkinson's Disease for Structural Variants

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Long‐read sequencing and optical genome mapping technologies have the ability to detect large and complex structural variants. This has led to the discovery of novel pathogenic variants in neurodegenerative movement disorders. Thus, we aimed to systematically compare the SV detection capabilities of OGM and ONT in Parkinson's disease.
André Fienemann, Theresa Lüth, Susen Schaake, Carolin Gabbert, Marius Möller, Hauke Busch, Katja Lohmann, Jonas A. Gustafson, Danny E. Miller, Kensuke Daida, Manabu Funayama, Nobutaka Hattori, Samia Ben Sassi, Faycel Hentati, Matthew J. Farrer, Kristian K. Ullrich, Christine Klein, Joanne Trinh   +17 more
wiley   +1 more source

Spatiotemporal Characteristic Investigation of Full-Aperture Grating Compressor for 100-PW Level Super-Intense Ultrafast Lasers

Ultrafast Science
The size of compression gratings has become a crucial factor in achieving 100-PW level super-intense ultrafast lasers, in view of the laser-induced damage of grating compressor.
Xingyan Liu, Fenxiang Wu, Yanqi Liu, Cheng Wang, Yi Xu, Yuxin Leng   +5 more
doaj   +1 more source

Magnetic Field in Nuclear Collisions at Ultra High Energies [PDF]

Physics, 2019
The magnetic field created in proton–proton and nucleus–nucleus collisions at ultra-high energies are studied with models of point-like charges and hard sphere for distribution of the constituents for vacuum conditions. The various beam ions are considered from light to heavy nuclei at energies corresponding to the nominal energies of the proton beam ...
openaire   +2 more sources