Results 61 to 70 of about 11,718,938 (295)

High-pressure neutron diffraction at ultra-low temperature

Physical Review Research
Neutron diffraction is a powerful tool in the study of quantum materials and associated emergent phenomena as it allows for direct detection of magnetic structure even at ultra-low temperatures.
Y. Wu, T. E. Sherline, J. J. Molaison, A. M. dos Santos, H. D. Zhou, H. B. Cao, J. J. Pierce, B. Haberl   +7 more
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Variation Resilient Adaptive Controller for Subthreshold Circuits

, 2009
Subthreshold logic is showing good promise as a viable ultra-low-power circuit design technique for power-limited applications. For this design technique to gain widespread adoption, one of the most pressing concerns is how to improve the robustness of ...
B. Mishra, Zwolinski, Mark, B.M. Al-Hashimi, Mishra, B, M. Zwolinski, Al-Hashimi, Bashir   +5 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

ULT freezer performance and dual-temperature storage in a modern biobank: preserving sample integrity during transition

Journal of Laboratory Medicine
This study evaluated temperature stability, warm-up characteristics, and energy consumption of ultra-low temperature (ULT) freezers operated at −80 °C, −70 °C, and −60 °C, to support sustainable storage practices in biobanking.
Madsen Corrie L., Høgdall Estrid
doaj   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Refrigeration down to 0.16 K using a frustrated magnet Gd2B2MoO9

Nature Communications
Magnetic refrigeration, utilizing the magnetocaloric effect in solid-state magnets, has emerged as a promising cooling technology. The development of practical ultra-low-temperature magnetic refrigeration applications has been limited by the absence of ...
Yikun Zhang, Yingzhe Na, Xinyang Liu, Junsen Xiang, Fengying Chen, Hai-Feng Li, Peijie Sun, Shengqiang Zhou, Xuefeng Zhang, Lingwei Li   +9 more
doaj   +1 more source

Ultra-low threshold continuous-wave quantum dot mini-BIC lasers

Light: Science & Applications, 2023
Highly compact lasers with ultra-low threshold and single-mode continuous wave (CW) operation have been a long sought-after component for photonic integrated circuits (PICs).
Hancheng Zhong, Ying Yu, Ziyang Zheng, Zhengqing Ding, Xuebo Zhao, Jiawei Yang, Yuming Wei, Yingxin Chen, Siyuan Yu   +8 more
doaj   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Geothermal power based ULTDH for cooling and heating purposes [PDF]

E3S Web of Conferences, 2019
Ultra-low temperature district heating systems facilitate use of waste and renewable heat sources. The article presents a possible scheme of operation and optimisation of small ultra-low temperature district heating system consisting of waste heat source,
Ciapała Bartłomiej, Janowski Mirosław
doaj   +1 more source