Results 61 to 70 of about 1,023,505 (330)

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

The hydrogen Lyman α line shape in the exospheres of terrestrial objects in the solar system

Frontiers in Astronomy and Space Sciences
The exospheres of all objects are mostly made of atomic hydrogen. Because the Sun is bright in Lyman α, the properties of the H atoms in the exospheres of certain terrestrial solar system objects can be studied by analyzing the resonantly scattered solar
Dolon Bhattacharyya, Edward M. B. Thiemann, Janet Machol, Janet Machol, Gonzalo Cucho-Padin, Gonzalo Cucho-Padin, Sabyasachi Chatterjee, Walter Harris, Edwin Mierkiewicz   +8 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Interband Tunneling for Hole Injection in III-Nitride Ultra-violet Emitters

, 2015
Ultra-violet emitters have several applications in the areas of sensing, water purification, and data storage. While the III-Nitride semiconductor system has the band gap region necessary for ultraviolet emission, achieving efficient ultraviolet solid ...
Akyol, Fatih, Allerman, Andrew, Armstrong, Andrew, Hwang, Jinwoo, Johnson, Jared M., Krishnamoorthy, Sriram, Moseley, Michael W., Rajan, Siddharth, Zhang, Yuewei   +8 more
core   +1 more source

Scientific Objectives for UV/Visible Astrophysics Investigations: A Summary of Responses by the Community (2012) [PDF]

, 2013
Following several recommendations presented by the Astrophysics Decadal Survey 2010 centered around the need to define "a future ultraviolet-optical space capability," on 2012 May 25, NASA issued a Request for Information (RFI) seeking persuasive ...
Benford, Dominic J., Neff, Susan G., Perez, Mario R., Scowen, Paul A.   +3 more
core   +5 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Light, including ultraviolet [PDF]

Journal of Autoimmunity, 2010
Ultraviolet (UV) light is intricately linked to the functional status of the cutaneous immune system. In susceptible individuals, UV radiation can ignite pathogenic inflammatory pathways leading to allergy or autoimmunity. In others, this same UV radiation can be used as a phototherapy to suppress pathogenic cutaneous immune responses.
Emanual, Maverakis, Yoshinori, Miyamura, Michael P, Bowen, Genevieve, Correa, Yoko, Ono, Heidi, Goodarzi   +5 more
openaire   +2 more sources

Shared Genetic Effects and Antagonistic Pleiotropy Between Multiple Sclerosis and Common Cancers

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epidemiologic studies have reported inconsistent altered cancer risk in individuals with multiple sclerosis (MS). Factors such as immune dysregulation, comorbidities, and disease‐modifying therapies may contribute to this variability.
Asli Buyukkurt, Marius Ygonia, Ali Manouchehrinia, Philippe Lefrançois, Ingrid Kockum, Adil Harroud   +5 more
wiley   +1 more source

Pr3+‐Based Visible‐to‐Ultraviolet Upconversion. A minireview

Advanced Physics Research
Optical upconversion materials doped with lanthanides, such as Yb3+‐Er3+, Yb3+‐Ho3+, and Yb3+‐Tm3+ coped systems, have been intensively studied over the past two decades because they can convert long‐wavelength and low‐energy near‐infrared photons into ...
Leipeng Li, Lingzhu Zi, Furong Yang, Shiji Feng, Chunzheng Wang, Yanmin Yang   +5 more
doaj   +1 more source

Effects of Biological Sex and Age on Cerebrospinal Fluid Markers—A Retrospective Observational Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cerebrospinal fluid (CSF) analysis is a key diagnostic tool for neurological diseases. To date, only a few studies have investigated in larger cohorts the effect of age and biological sex on diagnostic markers extracted from CSF. Methods For this retrospective observational study, 4163 CSF findings (2012–2020) were evaluated.
Isabel‐Sophie Hafer, Simon Faissner, Ralf Gold, Aiden Haghikia   +3 more
wiley   +1 more source