Results 11 to 20 of about 12,186 (217)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

FEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav, Bogdan I. Florea, Sebastian Geibel   +2 more
wiley   +1 more source

The Effect of the Velocity Distribution on Kilonova Emission

The Astrophysical Journal
The electromagnetic emission from the nonrelativistic ejecta launched in neutron star mergers (either dynamically or through a disk wind) has the potential to probe both the total mass and composition of this ejecta.
Chris L. Fryer, Aimee L. Hungerford, Ryan T. Wollaeger, Jonah M. Miller, Soumi De, Christopher J. Fontes, Oleg Korobkin, Atul Kedia, Marko Ristic, Richard O’Shaughnessy   +9 more
doaj   +1 more source

Statistical Study of Ejections in Coronal Hole Regions As Possible Sources of Solar Wind Switchbacks and Small-scale Magnetic Flux Ropes

The Astrophysical Journal Letters, 2023
The omnipresence of transient fluctuations in the solar wind, such as switchbacks (SBs) and small-scale magnetic flux ropes (SMFRs), have been well observed by the in situ observation of Parker Solar Probe (PSP), yet their sources are not clear. Possible
Nengyi Huang, Sophia D’Anna, Haimin Wang   +2 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Optical Appearance of Eccentric Tidal Disruption Events

The Astrophysical Journal Letters
Stars approaching supermassive black holes can be tidally disrupted. Despite being expected to emit X-rays, tidal disruption events (TDEs) have been largely observed in optical bands, which is poorly understood.
Fangyi (Fitz) Hu, Daniel J. Price, Ilya Mandel   +2 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Follow the Mass—A Concordance Picture of Tidal Disruption Events

The Astrophysical Journal
Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source