Results 21 to 30 of about 70,469 (251)

Pan-STARRS1 Discovery of Two Ultra-Luminous Supernovae at z ~ 0.9 [PDF]

, 2011
We present the discovery of two ultra-luminous supernovae (SNe) at z ~ 0.9 with the Pan-STARRS1 Medium-Deep Survey. These SNe, PS1-10ky and PS1-10awh, are amongst the most luminous SNe ever discovered, comparable to the unusual transients SN 2005ap and ...
A. M. Soderberg, A. Rest, A. Riess, Abazajian, Barbary, C. W. Stubbs, Chatzopoulos, Chevalier, Chevalier, Chevalier, Contardo, D. C. Martin, Drout, E. A. Magnier, E. Berger, Faber, Foley, Frail, Frail, G. Narayan, Gaensler, Gezari, Gänsicke, H. Flewelling, Hogg, I. Czekala, Immler, Ivezic, J. D. Neill, J. L. Tonry, J. S. Morgan, Jeffery, K. C. Chambers, K. C. Roth, K. Forster, Kasen, Katz, Kewley, Kocevski, L. Chomiuk, M. E. Huber, MacFadyen, Magnier, Malesani, Miller, Mink, Modjaz, N. E. Sanders, N. Kaiser, Nakar, Neill, Nugis, Ofek, Onaka, P. A. Price, Pastorello, Perley, Quimby, R. A. Chevalier, R. Chornock, R. J. Foley, R. J. Wainscoat, R. P. Kirshner, R.-P. Kudritzki, Rest, S. A. Rodney, S. Gezari, S. J. Smartt, Schlegel, Shklovskii, Smith, Smith, Smith, Stoll, Stubbs, Tonry, Tremonti, van der Horst, W. M. Wood-Vasey, W. S. Burgett, Woosley, York   +81 more
core   +2 more sources

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Optical Appearance of Eccentric Tidal Disruption Events

The Astrophysical Journal Letters
Stars approaching supermassive black holes can be tidally disrupted. Despite being expected to emit X-rays, tidal disruption events (TDEs) have been largely observed in optical bands, which is poorly understood.
Fangyi (Fitz) Hu, Daniel J. Price, Ilya Mandel   +2 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

The gamma-ray observatory [PDF]

, 1991
An overview is given of the Gamma Ray Observatory (GRO) mission. Detection of gamma rays and gamma ray sources, operations using the Space Shuttle, and instruments aboard the GRO, including the Burst and Transient Source Experiment (BATSE), the Oriented ...

core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Follow the Mass—A Concordance Picture of Tidal Disruption Events

The Astrophysical Journal
Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj   +1 more source

The photoswitchable cannabinoid azo‐HU308 enables optical control of Ca2+ dynamics in INS‐1 β‐cells via off‐target effects on TRPC channels

FEBS Open Bio, EarlyView.
Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley   +1 more source

Eight Years of Light from ASASSN-15oi: Toward Understanding the Late-time Evolution of TDEs

The Astrophysical Journal
We present results from an extensive follow-up campaign of the tidal disruption event (TDE) ASASSN-15oi spanning δt  ∼ 10–3000 days, offering an unprecedented window into the multiwavelength properties of a TDE during its first ≈8 yr of evolution. ASASSN-
A. Hajela, K. D. Alexander, R. Margutti, R. Chornock, M. Bietenholz, C. T. Christy, M. Stroh, G. Terreran, R. Saxton, S. Komossa, J. S. Bright, E. Ramirez-Ruiz, D. L. Coppejans, J. K. Leung, Y. Cendes, E. Wiston, T. Laskar, A. Horesh, G. Schroeder, Nayana A. J., M. H. Wieringa, N. Velez, E. Berger, P. K. Blanchard, T. Eftekhari, S. Gomez, M. Nicholl, H. Sears, B. A. Zauderer   +28 more
doaj   +1 more source