Results 51 to 60 of about 3,303 (174)
Journal of Ayurveda and Integrative Medicine, 2021 Inducible Nitric Oxide Synthase (iNOS) is a key mediator in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study aimed to evaluate if the hydroalcoholic leaf extract of Caryota urens (CULHA) consisting of rutin ...
Sujitha Balaji, Kripa Kavasseri Ganesan
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Cancer Science, Volume 117, Issue 6, Page 1713-1723, June 2026.A cell‐based high‐throughput screening system utilizing the luminescent probe LISA‐103 was developed to monitor γ‐glutamylcyclotransferase (GGCT) activity in cancer cells. Through this assay, plumbagin was identified as a novel GGCT inhibitor that induces cell cycle arrest and suppresses cancer cell growth. ABSTRACT γ‐Glutamylcyclotransferase (GGCT) is
Keiko Taniguchi +10 more
wiley +1 more source
Umbelliferone and Esculetin: Inhibitors or Substrates for Polyphenol Oxidases?
Biological and Pharmaceutical Bulletin, 2008 Recently, an interesting debate arose about the nature (substrate versus inhibitor) of esculetin, a coumarin derivative, for mushroom polyphenol oxidase (PPO). The present study examined the behavior of PPOs preparations from fungal and plant origin towards esculetin as a substrate. Both enzymes were able to oxidize esculetin though at a slow rate.
Sollai, F +4 more
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Journal of Lipid Research, 2015 Ceramidases catalyze the cleavage of ceramides into sphingosine and fatty acids. Previously, we reported on the use of the RBM14 fluorogenic ceramide analogs to determine acidic ceramidase activity.
Mireia Casasampere +12 more
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Food Science &Nutrition, Volume 14, Issue 5, May 2026.Food‐grade processing of Pastinaca sativa (parsnip) converts a nutrient‐rich plant matrix (dietary fiber, fructans, phenolics) through washing/slicing/enzymatic treatment and ingredient preparation into functional food ingredients, including fiber concentrates, antioxidant‐rich fractions, and parsnip powders/extracts.
Somanjana Khatua +7 more
wiley +1 more source
Química NovaA synthetic procedure for obtaining the fluorescent coumarin umbelliferone (7-hydroxycoumarin) and its spectral parameters were fully developed aiming at an undergraduate organic chemistry laboratory class.
Thiago M. Pereira +5 more
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Cell Proliferation, Volume 59, Issue 5, May 2026.This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang +10 more
wiley +1 more source
Chemical Constituents and Antidiabetic Activity of Dichloromethane Extract from Ficus carica Leaves
Diabetes, Metabolic Syndrome and Obesity, 2023 Limei Lin, Yin Zhang Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian, People’s Republic of ChinaCorrespondence: Yin Zhang, Department of Pharmacy, The Second Affiliated Hospital of Fujian Medical ...
Lin L, Zhang Y
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Advanced Science, Volume 13, Issue 21, 13 April 2026.This study reveals that chronic alcohol exposure selectively upregulates ACSL1 expression in prefrontal cortical microglia, driving lipid metabolism reprogramming and lipid droplet accumulation, which activates the NLRP3 inflammasome and sustains neuroinflammation. To reverse this process, a dual‐targeted lipid nanoparticle, siACSL1@LNP‐MR, is designed
Liang Hao +8 more
wiley +1 more source
Antifungal activity of davanone-type sesquiterpenes from Artemisia lobelii var. conescens [PDF]
Journal of the Serbian Chemical Society, 2004 Five tetrahydrofuran sesquiterpenes, so-called davanones, and coumarin umbelliferone isolated from Artemisia lobelii All. var. canescens (DC.) Briqu, were tested for antifungal activity. All the compounds inhibited the growth of the applied fungi.
VELE TESEVIC +5 more
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