Results 51 to 60 of about 1,187 (117)

Umbelliferone and scopoletin target tyrosine kinases on fibroblast-like synoviocytes to block NF-κB signaling to combat rheumatoid arthritis

Frontiers in Pharmacology, 2022
Rheumatoid arthritis (RA) is a complex autoimmune condition primarily affecting synovial joints, which targeted synthetic drugs have damaging safety issues.
Qilei Chen, Wenmin Zhou, Yueming Huang, Yuanyang Tian, Sum Yi Wong, Wing Ki Lam, Ka Yee Ying, Jianye Zhang, Hubiao Chen   +8 more
doaj   +1 more source

Raphani Semen Extract Targets the las Quorum Sensing System to Suppress Pseudomonas aeruginosa Biofilm and Signal Molecule Production

Food Science &Nutrition, Volume 14, Issue 8, August 2026.
Raphani Semen extract (RSE) and its characteristic isothiocyanates sulforaphane (SFA) and sulforaphene (SFE) inhibit Pseudomonas aeruginosa biofilm formation and virulence by targeting the las quorum sensing system. RSE reduces the autoinducer 3‐oxo‐C12‐HSL, downregulates QS genes, and suppresses motility and virulence factors. SFA and SFE recapitulate
Juntao Xie, Yujing Huang, Honggeng Chen, Zhiyun Xia, Likang Wang, Xin Yu, Jianni Yang, Jun Xu, Hongxia Fan, Junxia Zheng   +9 more
wiley   +1 more source

Twice as Nice: The Duff Formylation of Umbelliferone Revised

, 2021
More efficient and preferably more convenient and greener synthetic solutions in coumarin scaffold functionalization are in steady demand. The Duff ortho-formylation of unsubstituted umbelliferone was revised in this study.
Vadim V. Negrebetsky, Vladislav V. Skarga, Yuri I. Baukov, Mikhail V. Malakhov   +3 more
core   +1 more source

Scopoletin and umbelliferone protect hepatocytes against palmitate- and bile acid-induced cell death by reducing endoplasmic reticulum stress and oxidative stress [PDF]

, 2022
BACKGROUND: The number of patients with non-alcoholic fatty liver disease (NAFLD) is rapidly increasing due to the growing epidemic of obesity. Non-alcoholic steatohepatitis (NASH), the inflammatory stage of NAFLD, is characterized by lipid accumulation ...
Geng, Yana, Moshage, Han, Moshage, Han; id_orcid, Wu, Zongmei, Buist-Homan, Manon   +4 more
core   +2 more sources

Inhibition of inducible nitric oxide production by Caryota urens and its active constituents umbelliferone and rutin

Journal of Ayurveda and Integrative Medicine, 2021
Inducible Nitric Oxide Synthase (iNOS) is a key mediator in a variety of diseases, and thus it is interesting to discover new iNOS inhibitors. This study aimed to evaluate if the hydroalcoholic leaf extract of Caryota urens (CULHA) consisting of rutin ...
Sujitha Balaji, Kripa Kavasseri Ganesan
doaj   +1 more source

From Metabolites to Mechanisms: Scorzonera parviflora Aerial Parts and Roots Extracts Profiled by UPLC‐ESI‐MS/MS, In Vitro/In Silico Tests, and Network Analysis

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Scorzonera parviflora is considered a promising candidate for applications in the pharmaceutical, nutraceutical, and natural product industries. ABSTRACT In the present study, the extraction of Scorzonera parviflora aerial parts and roots was performed using four solvents, namely ethyl acetate (EA), ethanol, ethanol/water, and water. The total phenolic
Gokhan Zengin, Nilofar Nilofar, Gunes Ak, Eliana Fernandes, Luísa Custódio, Maria João Rodrigues, Shaza Aly, Omayma A. Eldahshan, Abdel Nasser Singab, Evren Yildiztugay, Milena Terzic, Meng‐Yao Li   +11 more
wiley   +1 more source

7-Acetoxycoumarin Inhibits LPS-Induced Inflammatory Cytokine Synthesis by IκBα Degradation and MAPK Activation in Macrophage Cells

Molecules, 2020
Acetylation involves the chemical introduction of an acetyl group in place of an active hydrogen group into a compound. In this study, we synthesized 7-acetoxycoumarin (7AC) from acetylation of umbelliferone (UMB).
Taejin Park, Jin-Soo Park, Ji Han Sim, Seung-Young Kim   +3 more
doaj   +1 more source

Evaluation of the in vitro biological activities of Banana flower and bract extracts and their bioactive compounds

International Journal of Food Properties, 2021
In this study, the banana flower was divided into bract and male flowers and extracted with water and ethanol, at different temperatures, and then the functionality of the obtained extract was evaluated and the bioactive compounds were analyzed.
Shu-Hua Chiang, Kia-Min Yang, Ying-Chiao Lai, Chih-Wei Chen   +3 more
doaj   +1 more source

Comparison of the Metabolites in Fingered Citron Fruit (Citrus medica L. var. sarcodactylis Swingle) and Chayote (Sechium edule) Based on UPLC‐Q‐Orbitrap MS/MS

Food Science &Nutrition, Volume 14, Issue 7, July 2026.
Untargeted UPLC‐Q‐Orbitrap MS/MS metabolomics was used to profile fingered citron (Citrus medica) from four Chinese production regions (CF1–CF4) and chayote (Sechium edule, CFM). Of 380 putatively annotated metabolites, 65 differential metabolites distinguished the five groups, clearly separating chayote from fingered citron and highlighting regional ...
Bin Li, Ruiyi Fan
wiley   +1 more source

Coumarins Disrupt Cell–Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon, Benjamin O'Rourke, Muireann Carmody, David F. Woods, Antje Gloe, Daniel Platero‐Rochart, Pedro A. Sánchez‐Murcia, Gerard P. McGlacken, F. Jerry Reen   +8 more
wiley   +1 more source