Results 51 to 60 of about 121,952 (309)

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

Optimal management of umbilical cord prolapse [PDF]

, 2018
Waleed Ali Sayed Ahmed, Mostafa Ahmed Hamdy Department of Obstetrics and Gynecology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt Abstract: Umbilical cord prolapse (UCP) is an uncommon obstetric emergency that can have significant ...
Hamdy MA, Sayed Ahmed WA
core  

Large cross-sectional area of the umbilical cord as a predictor of fetal macrosomia [PDF]

, 2007
Objective: To determine whether a large cross-sectional area of the umbilical cord is a predictor of fetal macrosomia. Methods: Consecutive patients of > 34 weeks' gestation, who presented for sonographic examination and who delivered within 4 weeks ...
Di naro, E, Cromi, A., A. Cromi, Bergamini, V., Ghezzi, F., E. D. Naro, BERGAMINI, VALENTINO, Siesto, G, G. Siesto, Bergamini, V, Ghezzi, F, DI NARO, Edoardo, E. Di Naro, Raio, L., L. Raio, F. Ghezzi, V. Bergamini, Raio, L, Siesto, G., Cromi, A   +19 more
core   +1 more source

Fetal heart rate evolution patterns in cerebral palsy associated with umbilical cord complications: a nationwide study

BMC Pregnancy and Childbirth, 2022
Background The aim of the present study was to clarify fetal heart rate (FHR) evolution patterns in infants with cerebral palsy (CP) according to different types of umbilical cord complications.
Junichi Hasegawa, Masahiro Nakao, Tomoaki Ikeda, Satoshi Toyokawa, Emi Jojima, Shoji Satoh, Kiyotake Ichizuka, Nanako Tamiya, Akihito Nakai, Keiya Fujimori, Tsugio Maeda, Satoru Takeda, Hideaki Suzuki, Shigeru Ueda, Mitsutoshi Iwashita, Tsuyomu Ikenoue   +15 more
doaj   +1 more source

Considering the Effects and Maternofoetal Implications of Vascular Disorders and the Umbilical Cord

Medicina, 2022
The umbilical cord is a critical anatomical structure connecting the placenta with the foetus, fulfilling multiple functions during pregnancy and hence influencing foetal development, programming and survival.
Lara Sánchez-Trujillo, Cielo García-Montero, Oscar Fraile-Martinez, Luis G. Guijarro, Coral Bravo, Juan A. De Leon-Luis, Jose V. Saez, Julia Bujan, Melchor Alvarez-Mon, Natalio García-Honduvilla, Miguel A. Saez, Miguel A. Ortega   +11 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

Umbilical Cord Coiling [PDF]

, 2019
The umbilical cord has a characteristic coiling pattern with both arteries coiling around the umbilical vein. This architecture is intrinsic to the cord and cannot be undone by unwinding in the opposite direction, unlike torsion.
Nikkels, PGJ, Cesar Peres, Luiz
core   +1 more source

Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank

Stem Cell Research & Therapy
Background Induced pluripotent stem cells (iPSCs) can differentiate into any type of cell and have potential uses in regenerative medicine for the treatment of many diseases. However, reducing immune rejection is a key problem in the application of iPSCs
Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu   +6 more
doaj   +1 more source

Case report: A case of malignant phyllodes tumor of the breast with concurrent epithelial malignancy and heterologous chondrosarcomatous differentiation

Frontiers in Oncology
The presence of malignant heterologous elements and malignant transformation of the epithelial component in phyllodes tumor (PT) is infrequent. The co-existence of both features within a single malignant PT is exceptionally rare and poorly documented. We
Jie Yuan, Hua Zhang, Jun Huang, Bei Wang, Geng Wang, Li Yang   +5 more
doaj   +1 more source

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source