Results 51 to 60 of about 303,748 (255)

Modulation of miR‐23b Wnt/β‐catenin Axis Strengthens Endothelial Barrier Properties

Advanced Science, EarlyView.
Early blood‐brain barrier (BBB) disruption contributes to stroke and CNS disease pathology. miR‐23b was identified as a regulator of BBB integrity in brain endothelial cells. Inhibition of miR‐23b enhanced barrier‐associated properties, promoted repair‐related signaling, and reduced BBB leakage in experimental stroke models, supporting further ...
Victor Anthony Martinez, Rose E. Presby, Sara Nakanishi, Pallavi Gaur, Ugur Akcan, Johannes Daugaard Krog, Iben Daugaard Krog, Lipi Das, David S. Johnson, Danny Jamoul, Douglas Jury, Brian Lawson, Jacob Körbelin, Lewis M. Brown, Vilas Menon, Dritan Agalliu, Irene Munk Pedersen   +16 more
wiley   +1 more source

Pre‐Regenerative Endothelial Cells Empowered by Antler Blood Exosomes Orchestrate Peripheral Nerve Repair

Advanced Science, EarlyView.
The pre‐regenerative vascular niche (PVN) is essential for nerve repair, yet its endothelial blueprint remains unclear. We identified angiogenic ECs (AECs) as the dominant pre‐regenerative subset and found that antler blood–derived exosomes (AB‐EXO) promote repair via IMP3.
Jinsheng Huang, Qiang Chen, Aihua Jin, Xiaoqi Yang, Hui Zhou, Weiquan Gong, Jin Cheng, Jun Dai, Minjin Wang, Meihua Piao, Yuanyi Wang, Nan Zhou   +11 more
wiley   +1 more source

Constructing a potential HLA haplo-homozygous induced pluripotent stem cell haplobank using data from an umbilical cord blood bank

Stem Cell Research & Therapy
Background Induced pluripotent stem cells (iPSCs) can differentiate into any type of cell and have potential uses in regenerative medicine for the treatment of many diseases. However, reducing immune rejection is a key problem in the application of iPSCs
Ji He, Yanmin He, Qigang Zhan, Zhipan Wu, Qi Sheng, Wei Zhang, Faming Zhu   +6 more
doaj   +1 more source

Case report: A case of malignant phyllodes tumor of the breast with concurrent epithelial malignancy and heterologous chondrosarcomatous differentiation

Frontiers in Oncology
The presence of malignant heterologous elements and malignant transformation of the epithelial component in phyllodes tumor (PT) is infrequent. The co-existence of both features within a single malignant PT is exceptionally rare and poorly documented. We
Jie Yuan, Hua Zhang, Jun Huang, Bei Wang, Geng Wang, Li Yang   +5 more
doaj   +1 more source

Fetal heart rate evolution patterns in cerebral palsy associated with umbilical cord complications: a nationwide study

BMC Pregnancy and Childbirth, 2022
Background The aim of the present study was to clarify fetal heart rate (FHR) evolution patterns in infants with cerebral palsy (CP) according to different types of umbilical cord complications.
Junichi Hasegawa, Masahiro Nakao, Tomoaki Ikeda, Satoshi Toyokawa, Emi Jojima, Shoji Satoh, Kiyotake Ichizuka, Nanako Tamiya, Akihito Nakai, Keiya Fujimori, Tsugio Maeda, Satoru Takeda, Hideaki Suzuki, Shigeru Ueda, Mitsutoshi Iwashita, Tsuyomu Ikenoue   +15 more
doaj   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

ANGPTL8 accelerates bone loss in diabetic mice by promoting osteoclastic differentiation and inhibiting osteoblastic differentiation through AMPK pathway-mediated metabolic reprogramming

Cellular and Molecular Life Sciences
Disruptions in energy metabolism within skeletal cells play a critical role in the pathogenesis of diabetic osteoporosis (DOP), primarily by affecting bone’s metabolic balance.
Peng Tuo, Wenbo Mu, Xinyu Bai, Suyin Wang, Liang Hu, Yining Xu, Ruopu Mao, Yixiang Liu, Yahong Yuan, Qiufang Zhang, Xingrong Guo, Shinan Ma, Xiaoli Wang   +12 more
doaj   +1 more source

Considering the Effects and Maternofoetal Implications of Vascular Disorders and the Umbilical Cord

Medicina, 2022
The umbilical cord is a critical anatomical structure connecting the placenta with the foetus, fulfilling multiple functions during pregnancy and hence influencing foetal development, programming and survival.
Lara Sánchez-Trujillo, Cielo García-Montero, Oscar Fraile-Martinez, Luis G. Guijarro, Coral Bravo, Juan A. De Leon-Luis, Jose V. Saez, Julia Bujan, Melchor Alvarez-Mon, Natalio García-Honduvilla, Miguel A. Saez, Miguel A. Ortega   +11 more
doaj   +1 more source

Cell separation and cryopreservation of cord blood fractions for immunotherapeutic applications [PDF]

, 2014
In 2008 Anthony Nolan opened the UK’s first public umbilical cord blood (CB) bank (Anthony Nolan Cell Therapy Centre, ANCTC) in which CB is stored for haematopoietic stem cell (HSC) transplantation. Due to strict quality thresholds, the majority of units
Fry, LJ
core  

Link Between Umbilical Cord Blood Adipokines and Early Childhood Health [PDF]

Introduction: Early-life neurological and inflammatory disorders significantly affect long-term cognitive, social, and emotional development. The ‘Developmental Origins of Health and Disease’ hypothesis states that an adverse intrauterine ...
Holland, OJ, Ava M. Boyle, Hryciw, DH, Deanne H. Hryciw, Boyle, AM, Olivia J. Holland   +5 more
core   +1 more source