Results 81 to 90 of about 204,149 (306)

Reprogramming Antitumor Immunity: NK Cell Strategies to Navigate the Immunosuppressive Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumor immune escape is a major barrier to durable cancer immunotherapy, as advanced malignancies create a tumor microenvironment (TME) that preferentially exhausts and disables T cell responses. While most approved cell therapies are T cell‐based, this limitation motivates the exploration of an alternative effector cell platform.
Tereza Kochs, Pranay Nath, Alice Chen, Rizwan Romee, Andreia Maia   +4 more
wiley   +1 more source

Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation

Frontiers in Oncology
IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression.
Jie Yuan, Bhanuprakash C. Narasimhachar, Bhanuprakash C. Narasimhachar, Akshay Ravish, Li Yang, Hua Zhang, Qun Wang, Zhi Li, Jun Huang, Bei Wang, Geng Wang, Keshav Kumar Harish, Arunachalam Chinnathambi, Chandramohan Govindasamy, Mahendra Madegowda, Basappa Basappa   +15 more
doaj   +1 more source

Personnel emergency carrier vehicle [PDF]

, 1987
A personnel emergency carrier vehicle is disclosed which includes a vehicle frame supported on steerable front wheels and driven rear wheels. A supply of breathing air is connected to quick connect face mask coupling and umbilical cord couplings for ...
Fedor, Otto H., Owens, Lester J.
core   +1 more source

Can the cerebroplacental ratio (CPR) predict intrapartum fetal compromise? : a prospective observational study [PDF]

, 2017
Objective: To investigate the potential clinical use of serial fetal CPR measurements during the last month of pregnancy for the prediction of adverse perinatal outcome in unselected low-risk pregnancies.
Dehaene, Isabelle, Page, Ann-Sophie, Page, Geert, Roelens, Kristien, Roets, Ellen   +4 more
core   +1 more source

Scalable Engineering of Bio‐Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient‐Derived Models

Advanced Science, EarlyView.
Engineered extracellular vesicles displaying Ephrin‐B2 selectively target Ephrin‐B4–expressing ovarian cancer cells, enabling precise delivery in patient‐derived models. This scalable bio‐manufacturing platform reveals a versatile strategy to exploit Ephrin signaling for highly specific therapeutic payload delivery and motivates exploration of tailored
Nihar Godbole, Andrew Lai, Alexander Quinn, Marianne Gillard, Dominic Guanzon, Katherin Scholz‐Romero, Alexis Salas‐Burgos, Bastián Lillo Dapremont, Rohan Lourie, Naven Chetty, Richard Lobb, Kate Beecher, Amy E. McCart Reed, Kaltin Ferguson, Biao Sun, Yaowu He, John D. Hooper, Carlos Salomon   +17 more
wiley   +1 more source

A partial supernumerary umbilical vein: a case report

Journal of Medical Case Reports, 2019
Background Abnormalities in the number of vessels can be found for both the umbilical artery and vein. We sometimes encounter cases of a decreased number of umbilical cord vessels, such as a single umbilical artery.
Mariko Kurakazu, Masamitsu Kurakazu, Masaharu Murata, Tatsuki Miyamoto, Yoko Takahashi, Makoto Hamasaki, Eiji Ohta, Fusanori Yotsumoto, Shingo Miyamoto   +8 more
doaj   +1 more source

Clinical characteristics and perinatal outcomes of eight cases of umbilical cord vascular rupture

Journal of International Medical Research, 2020
Objectives To analyze the clinical characteristics and perinatal outcomes of umbilical cord vascular rupture, and to investigate the diagnosis and treatment strategies for reducing adverse perinatal outcomes.
Xiaomei Wang, Zhaozhen Liu, Shouzhen Chen, Yu Wang, Sheng Lin   +4 more
doaj   +1 more source

Generation of Functional CLL-Specific Cord Blood CTL Using CD40-Ligated CLL APC [PDF]

, 2012
PMCID: PMC3526610This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Trojan, AD Hamblin, AG Ramsay, AG Ramsay, AM Krackhardt, AP Kater, AP Kater, BL McClune, C Haller, C Mayr, C Nabhan, CA Rodrigues, D Bagnara, D Dilloo, D Wolf, D Xing, DA Mavroudis, DL Porter, Dongxia Xing, Elizabeth J. Shpall, Hiroshi Shiku, Hong Yang, I Ben-Bassat, I Hus, IF Khouri, J Chen, Jeffrey J. Molldrem, JG Gribben, JG Gribben, JM Rudolph, John G. Gribben, JS Miller, K Kato, M Hoogendorn, M Ritgen, MA King, Matthew M. Halpert, MF Bachmann, Michael J. Keating, N Shah, Nina Shah, R Le Dieu, R Mous, Ruth Lapushin, S Miscia, S Parmar, S Samarasinghe, Simon N. Robinson, Simrit Parmar, SL Martins, SM Schmidt, Sufang Li, T Nishida, WG Wierda, William G. Wierda, William K. Decker, WK Decker   +56 more
core   +2 more sources

Biomimetic Bone Marrow Monocyte Membrane‐Fused Extracellular Vesicles for Targeted Therapy of Myocardial Infarction

Advanced Science, EarlyView.
This study develops a biomimetic delivery system (M‐hEV) by fusing monocyte membranes with extracellular vesicles for targeted therapy of damaged cardiac tissue. The system homes to injured myocardium through specific molecular pathways. In a myocardial infarction model, M‐hEV effectively accumulates in the heart, reduces infarct size, alleviates ...
Jiaxin Song, Hao Yang, Qiqi Zhang, Wenqin Zhou, Rui Wang, Yuxing Xie, Emeli Chatterjee, Guoping Li, Jizong Jiang, Qiulian Zhou, Cuimei Zhao   +10 more
wiley   +1 more source

“The cord is the child”: meanings and practices related to umbilical cord care in Central Uganda

BMC Pediatrics, 2020
Background Infections account for a quarter of all newborn deaths and the umbilical cord has been identified as a major route of newborn infections.
David Mukunya, Marte E. S. Haaland, James K. Tumwine, Thorkild Tylleskar, Victoria Nankabirwa, Karen Marie Moland   +5 more
doaj   +1 more source