Results 71 to 80 of about 104,266 (277)

Microstructural Correlates of Resilience against Major Depressive Disorder: Epigenetic Mechanisms? [PDF]

, 2010
Mental disorders are a major cause of long-term disability and are a direct cause of mortality, with approximately 800.000 individuals dying from suicide every year worldwide - a high proportion of them related to major depressive disorder (MDD)^1 ...
Andrew Fagan, Angela Carballedo, Danusia Lisiecka, Dermot Kelleher, Ian Daly, James Meaney, Thomas Frodl, Thomas Frodl, Yolande Ferguson   +8 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Minor physical anomalies in patients with schizophrenia, unaffected first-degree relatives, and healthy controls: a meta-analysis.

PLoS ONE, 2011
BackgroundMinor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia.AimTo quantitatively define the magnitude of the ...
Ting Xu, Raymond C K Chan, Michael T Compton   +2 more
doaj   +1 more source

Evidence of widespread retinal dysfunction in patients with stargardt disease and morphologically unaffected carrier relatives [PDF]

, 2008
PURPOSE: To characterize contrast sensitivity (CS) across the visual field for two achromatic spatial-temporal frequencies in 21 families with Stargardt disease (STGD) and to correlate psychophysical impairment with patterns of change in multifocal ...
Castelo-Branco, Miguel, Faria, Pedro, Maia-Lopes, Susana, Reis, Aldina, Silva, Eduardo D., Silva, Maria Fátima   +5 more
core   +1 more source

Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives [PDF]

Psychological Medicine, 2019
AbstractBackgroundPatients with bipolar disorder (BD) experience persistent impairments in both affective and non-affective cognitive function, which is associated with a worse course of illness and poor functional outcomes. Nevertheless, the temporal progression of cognitive dysfunction in BD remains unclear and the identification of objective ...
Hanne Lie Kjærstad, Nicolaj Mistarz, Klara Coello, Sharleny Stanislaus, Sigurd Arne Melbye, Catherine J. Harmer, Maj Vinberg, Kamilla Miskowiak, Lars Vedel Kessing   +8 more
openaire   +4 more sources

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes

International Journal of Bipolar Disorders, 2021
Background Understanding the underlying architecture of mood regulation in bipolar disorder (BD) is important, as we are starting to conceptualize BD as a more complex disorder than one of recurring manic or depressive episodes.
Abigail Ortiz, Kamil Bradler, Maxine Mowete, Stephane MacLean, Julie Garnham, Claire Slaney, Benoit H. Mulsant, Martin Alda   +7 more
doaj   +1 more source

Reconceptualising temporality in young lives: exploring young people’s current and future livelihoods in AIDS-affected southern Africa [PDF]

, 2013
In recent years, anxieties have been expressed that the impacts of southern Africa's AIDS pandemic on young people today will damage their future livelihood prospects.
Abebe, Abebe, Abebe, Ainsworth, Ansell, Ansell, Bailey, Bissell, Blerk, Blerk, BOS, Bourdillon, Boyden, Bryceson, Cass, Chambers, Chant, Conticini, Crush, Dahlblom, Dorward, Evans, Grieco, Grosz, Haan, Hajdu, Hampshire, Harker, Heady, Hopkins, Horton, Horton, Jaiyebo, James, Jeffrey, Johnson-Hanks, Katz, Kesby, Langevang, Langevang, Lefoka, Loevinsohn, Mabala, MacDonald, Murray, Pain, Punch, Republic of Malawi, Robson, Robson, Teather, UNAIDS, Uprichard, Valentine, Worth, Yin   +55 more
core   +2 more sources

Altered immune function in unaffected first-degree biological relatives of schizophrenia patients

Psychiatry Research, 2012
Inflammatory and immune processes have been implicated in the etiopathology of schizophrenia. We demonstrate the existence of immune function alteration, assessed by serum cytokine's levels, not only in schizophrenia patients but also in their unaffected first-degree relatives.
Martínez-Gras, I., García-Sánchez, F., Guaza, Carmen, Rodríguez-Jiménez, R., Andrés-Esteban, E., Palomo, T., Rubio, G., Borrell, José   +7 more
openaire   +3 more sources

Prolongation of Brainstem Auditory-Evoked Responses in Autistic Probands and Their Unaffected Relatives [PDF]

Archives of General Psychiatry, 2000
Brain function, as indexed by brain electrical activity, is heritable in humans, and it may be impaired in autism. Autism also has strong genetic determinants, and like all major psychiatric disorders, its complex clinical phenotype renders genetic studies difficult.
M, Maziade, C, Mérette, M, Cayer, M A, Roy, P, Szatmari, R, Côté, J, Thivierge   +6 more
openaire   +2 more sources