Results 51 to 60 of about 491,727 (238)

Aggressiveness and emotion dysregulation among adolescents first degree relatives of schizophrenia patients

European Psychiatry, 2023
Introduction Schizophrenia is a severe debilitating condition, with elevated level of aggressiveness reaching 33% in a large sample of patients. Unaffected biological relatives of schizophrenia patients share similar though less severe neurocognitive ...
F. Ghrissi, F. Fekih-romdhane, M. Stambouli, B. Abassi, M. Cheour   +4 more
doaj   +1 more source

Normal cerebral asymmetry in familial and non-familial schizophrenic probands and their unaffected relatives

, 2004
Loss of normal fronto-occipital cerebral asymmetry has been reported in patients with schizophrenia and also in their well relatives from multiply affected families, suggesting a relationship with susceptibility genes.
Murray, RM, Toulopoulou, T, Schulze, K., McDonald, C., Murray, R M, Chapple, B, Walshe, M., Toulopoulou, T., Morgan, K.D., Walshe, M, Grech, A., Murray, R.M., Schulze, K, McDonald, C, Sham, P., Grech, A, Morgan, K, Sham, P, Chapple, B.   +18 more
core   +1 more source

Genotypes for the c.1190G>A variant in affected cats and unaffected relatives.

, 2015
Genotypes for the c.1190G>A variant in affected cats and unaffected relatives.
Nicolas Blanchard-Gutton (790793), Anne Thomas (90885), Christophe Hitte (2624), Lionel Martignat (790794), Philippe Bossé (61688), Stéphane Blot (119054), Laurent Tiret (128972), Marie Abitbol (703386)   +7 more
core   +1 more source

Effect sizes and confidence intervals for each study in the meta-analysis involving unaffected relatives and healthy controls.

, 2013
Effect sizes and confidence intervals for each study in the meta-analysis involving unaffected relatives and healthy controls.
Raymond C. K. Chan (150851), Ting Xu (215531), Michael T. Compton (344630)   +2 more
core   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

The futility of long-term predictions in bipolar disorder: mood fluctuations are the result of deterministic chaotic processes

International Journal of Bipolar Disorders, 2021
Background Understanding the underlying architecture of mood regulation in bipolar disorder (BD) is important, as we are starting to conceptualize BD as a more complex disorder than one of recurring manic or depressive episodes.
Abigail Ortiz, Kamil Bradler, Maxine Mowete, Stephane MacLean, Julie Garnham, Claire Slaney, Benoit H. Mulsant, Martin Alda   +7 more
doaj   +1 more source

Prediction of Neurocognitive Deficits by Parkinsonian Motor Impairment in Schizophrenia: A Study in Neuroleptic-Naïve Subjects, Unaffected First-Degree Relatives and Healthy Controls From an Indigenous Population

, 2016
Background: Neurocognitive deficits are among the most debilitating and pervasive symptoms of schizophrenia, and are present also in unaffected first-degree relatives.
Padilla, Eduardo, Calvó, María, González Alemán, Gabriela, Toranzo, Juan, Florenzano, Néstor, Kamis, Danielle, de Erausquin, Gabriel A., Stratton, Lee, Molina, Juan L., Guerrero, Gonzalo   +9 more
core   +1 more source