Results 71 to 80 of about 103,359 (288)
PLoS ONE, 2011 BackgroundMinor physical anomalies (MPAs) have been found to be more prevalent in schizophrenia than control participants in numerous studies and may index a potential endophenotype for schizophrenia.AimTo quantitatively define the magnitude of the ...
Ting Xu +2 more
doaj +1 more source
A Female Patient with Down Syndrome and Low-Penetrance Leber's Hereditary Optic Neuropathy. [PDF]
, 2014 We present the case of a 19-year-old female with a history of Down syndrome (DS) who was referred to our neuro-ophthalmology clinic for evaluation of Leber's hereditary optic neuropathy (LHON).
Frousiakis, Starleen E +3 more
core +3 more sources
Aberrant cognition in newly diagnosed patients with bipolar disorder and their unaffected relatives [PDF]
Psychological Medicine, 2019 AbstractBackgroundPatients with bipolar disorder (BD) experience persistent impairments in both affective and non-affective cognitive function, which is associated with a worse course of illness and poor functional outcomes. Nevertheless, the temporal progression of cognitive dysfunction in BD remains unclear and the identification of objective ...
Hanne Lie Kjærstad +8 more
openaire +4 more sources
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source
SAGE Open, 2012 The study aims to evaluate the neuropsychological functions of unaffected first-degree relatives of patients with bipolar disorder Type I (BD-I) in comparison with healthy controls. The method was a cross-sectional assessment of 20 first-degree relatives
Raman Deep Pattanayak +2 more
doaj +1 more source
Frontiers in Psychiatry, 2013 The nicotinic system is involved in the pathophysiology of schizophrenia. However, very little is known about its genetic basis and how it relates to clinical symptoms and potentially pharmacological intervention.
George eBakanidze +8 more
doaj +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Obstetric prognosis in sisters of preeclamptic women – implications for genetic linkage studies [PDF]
, 2003 Background To investigate obstetric prognosis in sisters of preeclamptic women. Methods We identified consecutive 635 sib pairs from the Birth Registry data of Kuopio University Hospital who had their first delivery between January 1989 and December 1999
Nonna Heiskanen +2 more
core +2 more sources
Altered immune function in unaffected first-degree biological relatives of schizophrenia patients
Psychiatry Research, 2012 Inflammatory and immune processes have been implicated in the etiopathology of schizophrenia. We demonstrate the existence of immune function alteration, assessed by serum cytokine's levels, not only in schizophrenia patients but also in their unaffected first-degree relatives.
Martínez-Gras, I. +7 more
openaire +3 more sources
Prolongation of Brainstem Auditory-Evoked Responses in Autistic Probands and Their Unaffected Relatives [PDF]
Archives of General Psychiatry, 2000 Brain function, as indexed by brain electrical activity, is heritable in humans, and it may be impaired in autism. Autism also has strong genetic determinants, and like all major psychiatric disorders, its complex clinical phenotype renders genetic studies difficult.
M, Maziade +6 more
openaire +2 more sources