Results 71 to 80 of about 491,727 (238)

Investigating the familial basis of heightened risk-taking in adolescents with conduct disorder and their unaffected relatives

, 2016
Previous studies have demonstrated increased risk-taking in adolescents with Conduct Disorder (CD) compared with typically developing controls. Increased risk-taking may partly mediate the pathway from genetic or environmental risk to CD. We investigated
Sully, Kate, Savage, Justin, Barke, Edmund, Savage, Justin C. D., Sonuga-Barke, Edmund J.S.; id_orcid, Sonuga-Barke, Edmund J. S., Fairchild, Graeme   +6 more
core   +1 more source

Impaired theory of mind in unaffected first‐degree relatives of patients with anorexia nervosa [PDF]

, 2019
Objective Previous studies have shown theory of mind (ToM) is affected in patients with anorexia nervosa (AN). There has also been growing interest in the study of endophenotypes in psychiatric disorders, since they allow better understanding of genetic
Ricardo F. Allegri, Tapajoz Pereira de Sampaio, Fernanda, Soneira, Sebastián, Sebastian Soneira, Alfredo Aulicino, Aulicino, Alfredo, Allegri, Ricardo Francisco, Natalia Catoira, Tapajóz, Fernanda, Catoira, Natalia, Fernanda Tapajóz, Allegri, Ricardo F.   +11 more
core   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source

Familial Aggregation of High Tumor Necrosis Factor Alpha Levels in Systemic Lupus Erythematosus

Clinical and Developmental Immunology, 2013
Systemic lupus erythematosus (SLE) patients frequently have high circulating tumor necrosis factor alpha (TNF-α) levels. We explored circulating TNF-α levels in SLE families to determine whether high levels of TNF-α were clustered in a heritable pattern.
Dorothy Mangale, Silvia N. Kariuki, Beverly S. Chrabot, Marissa Kumabe, Jennifer A. Kelly, John B. Harley, Judith A. James, Kathy L. Sivils, Timothy B. Niewold   +8 more
doaj   +1 more source

An outer membrane vesicle‐associated two‐track model for enterotoxigenic Bacteroides fragilis oncogenesis

Molecular Oncology, EarlyView.
Enterotoxigenic Bacteroides fragilis is a gut bacterium linked to bowel cancer. We propose that its toxin acts along two routes: at the cell surface, cutting the adhesion protein E‐cadherin and triggering inflammation; and inside the cell, delivered by bacterial vesicles, switching on NOD1 and cancer stem cell programs.
Kangchan Choi, Sang‐Hyeon Yoo, Ki‐Jong Rhee   +2 more
wiley   +1 more source

Distinct Associations of Motor Domains in Relatives of Schizophrenia Patients—Different Pathways to Motor Abnormalities in Schizophrenia?

Frontiers in Psychiatry, 2018
IntroductionAberrant motor function is an integral part of schizophrenia. In fact, abnormalities are frequently found in patients, in populations at risk, and in unaffected relatives.
Lea Schäppi, Katharina Stegmayer, Petra V. Viher, Sebastian Walther   +3 more
doaj   +1 more source

Neurocognitive profile in Indian individuals genetically at risk of schizophrenia

Indian Journal of Psychological Medicine, 2020
Background: Cognitive deficits have been noted in patients of schizophrenia in remission, as well as in first-degree relatives. This study aims to evaluate the neurocognitive performance in unaffected first-degree relatives of patients of schizophrenia ...
Sunny Chattopadhyay, Nanasaheb M Patil, Raghavendra B Nayak, Sameeran S Chate, Om P Singh   +4 more
doaj   +1 more source

Association between neurological soft signs, temperament and character in patients with schizophrenia and non-psychotic relatives [PDF]

PeerJ, 2016
The heritability of schizophrenia and most personality traits has been well established, but the role of personality in susceptibility to schizophrenia remains uncertain. The aim of this study was to test for an association between personality traits and
Liliana Galindo, Francisco Pastoriza, Daniel Bergé, Anna Mané, Marisol Picado, Antonio Bulbena, Patricia Robledo, Victor Pérez, Oscar Vilarroya, Claude Robert Cloninger   +9 more
doaj   +2 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Hippocampal volume in familial and nonfamilial schizophrenic probands and their unaffected relatives

, 2003
Background: There is evidence for hippocampal volume loss in schizophrenia, but the etiology of this remains unclear. The aim of our study was to assess the contribution of familial liability and obstetric complications to hippocampal volume reduction in
Taylor, M, Murray, RM, Colm McDonald, Thordur Sigmundsson, Toulopoulou, T, Timothea Toulopoulou, Murray, R M, Frangou, S, Tonmoy Sharma, Anton Grech, Walshe, M, Sophia Frangou, Sigmundsson, T, Mark Taylor, Schulze, K, McDonald, C, Grech, A, Katja Schulze, Robin M Murray, Pak Sham, Sham, P, Sharma, T, Muriel Walshe   +22 more
core   +1 more source