Results 91 to 100 of about 103,359 (288)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Characterization of apoA- and apoB-containing lipoprotein particles in a variant of familial apoA-I deficiency with planar xanthoma: the metabolic significance of LP-A-II particles.

Journal of Lipid Research, 1991
This study describes a variant of familial apoA-I deficiency associated with a moderate risk for premature coronary artery disease. The proband, a 25-year-old man of Philippine origin, and his 62-year-old maternal aunt had peripheral corneal ...
ED Bekaert, P Alaupovic, CS Knight-Gibson, MJ Laux, JM Pelachyk, RA Norum   +5 more
doaj   +1 more source

Individual correlates of podoconiosis in areas of varying endemicity: a case-control study [PDF]

, 2013
BACKGROUND Podoconiosis is a non-filarial form of elephantiasis resulting in lymphedema of the lower legs. Previous studies have suggested that podoconiosis arises from the interplay of individual and environmental factors.
A Tora, A Tora, AP Oomen, B Yakob, C Sikorski, D Ayode, EW Price, EW Price, EW Price, EW Price, EW Price, EW Price, EW Price, EW Price, EW Price, EW Price, F Tekola, F Tekola, F Tekola, F Tekola Ayele, F Tekola Ayele, F Tekola Ayele, FL Filon, G Alemu, G Davey, G Davey, G Davey, G Davey, G Geshere Oli, G Mengistu, Gail Davey, H Birrie, H Kloos, Jennifer S. Le Blond, John Owusu Gyapong, K Desta, K Destas, M Abraha, M Perera, Melanie J. Newport, Nicola Wardrop, P Nenoff, Peter Baxter, Peter M. Atkinson, PJ Hotez, S Tomczyk, YB Molla, YB Molla, Yordanos B. Molla   +48 more
core   +3 more sources

Anti–Citrullinated Protein Antibodies in Unaffected First‐Degree Relatives of Rheumatoid Arthritis Patients

Arthritis & Rheumatism, 2013
ObjectiveFirst‐degree relatives (FDRs) of rheumatoid arthritis (RA) patients sharing genetic and environmental risk factors for RA may represent a pre‐RA state. Since anti–cyclic citrullinated protein/peptide antibodies (ACPAs) appear years before the onset of RA, the purpose of this study was to determine the prevalence of various ACPAs in FDRs of RA ...
Barra, Lillian, Scinocca, Mathias, Saunders, Sheri, Bhayana, Rajesh, Rohekar, Sherry, Racapé, Maud, Coles, Robert, Cairns, Ewa, Bell, David A.   +8 more
openaire   +4 more sources

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Subtle Cerebellar Features in Relatives of Essential Tremor Cases

Frontiers in Neurology, 2020
Background: Essential tremor (ET) cases often exhibit a range of mild cerebellar signs. Their unaffected relatives have been shown in prior studies to exhibit subtle (i.e., preclinical) disease features.Objective: To quantify subtle cerebellar signs in ...
Evan A. Hale, Ruby Hickman, Hollie Dowd, Deepti Varathan, Gina Liu, Elan D. Louis, Elan D. Louis, Elan D. Louis, Elan D. Louis   +8 more
doaj   +1 more source

‘Once upon a time …’ Orphanhood, childhood studies and the depoliticisation of childhood poverty in southern Africa [PDF]

, 2015
Policy, interventions and research concerning southern African children remain dominated by a focus on AIDS-related orphanhood, although the association between orphanhood and disadvantage is highly questionable. I argue that the trope of the AIDS orphan
Ansell, N
core   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

The antisaccade task as a research tool in psychopathology: A critical review [PDF]

, 2006
The antisaccade task is a measure of volitional control of behavior sensitive to fronto-striatal dysfunction. Here we outline important issues concerning antisaccade methodology, consider recent evidence of the cognitive processes and neural mechanisms ...
Ettinger, Ulrich, Hutton, Samuel
core   +1 more source

Evidence of widespread retinal dysfunction in patients with stargardt disease and morphologically unaffected carrier relatives [PDF]

, 2008
PURPOSE: To characterize contrast sensitivity (CS) across the visual field for two achromatic spatial-temporal frequencies in 21 families with Stargardt disease (STGD) and to correlate psychophysical impairment with patterns of change in multifocal ...
Castelo-Branco, Miguel, Faria, Pedro, Maia-Lopes, Susana, Reis, Aldina, Silva, Eduardo D., Silva, Maria Fátima   +5 more
core   +1 more source