Results 1 to 10 of about 16,681 (209)
Schizophrenia endophenotypes: a review of neurophysiological, neuropsychological, and social cognition markers [PDF]
Frontiers in PsychiatryIntroductionIn schizophrenia (SCZ) research, endophenotypes represent intermediate links between the polygenic architecture of the disorder and clinical phenomenology.
Ricardo R. Garcia +2 more
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Endophenotype Research in Epilepsy Across Time [PDF]
Brain SciencesBackground/Objectives: Endophenotypes—quantifiable biological markers bridging genetic variations and clinical manifestations—have significantly evolved since their introduction to psychiatric genetics.
Ozgun Yetkin +3 more
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Determinants of Schizophrenia Endophenotypes Based on Neuroimaging and Biochemical Parameters
Biomedicines, 2021 Despite extensive research, there is no convincing evidence of a reliable diagnostic biomarker for schizophrenia beyond clinical observation. Disorders of glutamatergic neurotransmission associated with N-methyl-D-aspartate (NMDA) receptor insufficiency,
Anna Skalniak +2 more
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Epigenetic equilibrium in chromatinopathies: network instability in neurodevelopment [PDF]
Frontiers in NeurologyBackgroundChromatin-modifying systems regulate transcriptional programs essential for human neurodevelopment through dynamic modification of histones, DNA, and higher-order chromatin architecture.
Himanshu Goel
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Frontiers in Pharmacology, 2022 Exposure to intermittent repeated social defeat (IRSD) increases the vulnerability of mice to the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm.
C. Calpe-López +3 more
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Neurocognitive Endophenotypes for Eating Disorders: A Preliminary High-Risk Family Study
Brain Sciences, 2023 Eating disorders (EDs) are psychiatric disorders with a neurobiological basis. ED-specific neuropsychological and brain characteristics have been identified, but often in individuals in the acute phase or recovered from EDs, precluding an understanding ...
Edoardo Pappaianni +5 more
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Frontiers in Behavioral Neuroscience, 2020 The relationship between stress and drug use is well demonstrated. Stress-induced by repeated social defeat (RSD) enhances the conditioned place preference (CPP) induced by cocaine in mice.
Claudia Calpe-López +4 more
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Brain Sciences, 2021 Learning disabilities (LDs) have an estimated prevalence between 5% and 9% in the pediatric population and are associated with difficulties in reading, arithmetic, and writing.
Rubén Pérez-Elvira +5 more
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Frontiers in Psychiatry, 2020 Deficits in the gating of sensory stimuli, i.e., the ability to suppress the processing of irrelevant sensory input, are considered to play an important role in the pathogenesis of several neuropsychiatric disorders, in particular schizophrenia.
Rastislav Rovný +3 more
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Possible clinical applications of knowledge about the genetics of type 2 diabetes
Медицинский совет, 2022 Type 2 diabetes mellitus (T2DM) is a polygenic disease that develops as a result of the interaction of hereditary predisposition and environmental factors.
T. Yu. Demidova, V. M. Plakhotnyaya
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