Results 21 to 30 of about 16,681 (209)
Frontiers in Molecular Neuroscience, 2022 Larval zebrafish are often used to model anxiety disorders. However, since it is impossible to recapitulate the full complexity and heterogeneity of anxiety in this model, examining component endophenotypes is key to dissecting the mechanisms underlying ...
Ruey-Kuang Cheng +4 more
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Modules for Automated Validation and Comparison of Models of Neurophysiological and Neurocognitive Biomarkers of Psychiatric Disorders: ASSRUnit—A Case Study [PDF]
Computational Psychiatry, 2018 The characterization of biomarkers has been a central goal of research in psychiatry over the last years. While most of this research has focused on the identification of biomarkers, using various experimental approaches, it has been recognized that ...
Christoph Metzner +3 more
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Molecules, 2019 Currently, there are no approved pharmacotherapies for addiction to cocaine and other psychostimulant drugs. Several studies have proposed that cannabidiol (CBD) could be a promising treatment for substance use disorders. In the present work, the authors
Claudia Calpe-López +2 more
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Animal models of developmental dyslexia
Frontiers in Neuroscience, 2022 As some critics have stated, the term “developmental dyslexia” refers to a strictly human disorder, relating to a strictly human capacity – reading – so it cannot be modeled in experimental animals, much less so in lowly rodents.
Albert M. Galaburda
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Endophenotype best practices [PDF]
International Journal of Psychophysiology, 2017 This review examines the current state of electrophysiological endophenotype research and recommends best practices that are based on knowledge gleaned from the last decade of molecular genetic research with complex traits. Endophenotype research is being oversold for its potential to help discover psychopathology relevant genes using the types of ...
William G, Iacono +2 more
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Impulsive and Omission Errors: Potential Temporal Processing Endophenotypes in ADHD
Brain Sciences, 2021 Temporal processing (TP) is associated with functions such as perception, verbal skills, temporal perspective, and future planning, and is intercorrelated with working memory, attention, and inhibitory control, which are highly impaired in individuals ...
Johan E. Acosta-López +16 more
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Endophenotype: a conceptual analysis [PDF]
Molecular Psychiatry, 2010 This paper provides a conceptual analysis of the endophenotype (EP) construct that is having an increasing role in genetic strategies for unraveling the etiology of psychiatric disorders (PDs). We make six major points illustrated through the method of path analysis.
K S, Kendler, M C, Neale
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The Mediation Role of Dynamic Multisensory Processing Using Molecular Genetic Data in Dyslexia
Brain Sciences, 2020 Although substantial heritability has been reported and candidate genes have been identified, we are far from understanding the etiopathogenetic pathways underlying developmental dyslexia (DD).
Sara Mascheretti +10 more
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Brain Sciences, 2021 Attention deficit hyperactivity disorder (ADHD) is a highly heritable neurobehavioral disorder that affects children worldwide, with detrimental long-term consequences in affected individuals.
Martha L. Cervantes-Henriquez +14 more
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Advances in endophenotyping schizophrenia [PDF]
World Psychiatry, 2008 The search for the genetic architecture of schizophrenia has employed multiple, often converging strategies. One such strategy entails the use of tracing the heritability and neurobiology of endophenotypes. Endophenotypes are quantifiable traits not visible to the eye, which are thought to reflect an intermediate place on the path from genes to ...
David L, Braff +4 more
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