Results 41 to 50 of about 16,681 (209)

Chronological Age and Adaptive Outcomes Following Neuropsychomotor and Aquatic Interventions in Children with Autism: A Secondary Analysis

Children
Background: Autism Spectrum Disorder (ASD) can be conceptualized not as a static condition but as a dynamic disorder of developmental regulation, in which neuroplastic potential is translated into functional gains only through structured, experience ...
Martina Gnazzo, Giuditta Bargiacchi, Valentina Baldini, Maria Esposito, Rosa Passerini, Emanuela Varriale, Francesco Cerroni, Eva Germanò, Agata Maltese, Lucia Parisi, Michele Roccella, Giulia Spoto, Gabriella Di Rosa, Rita Barone, Lidia Scifo, Beatrice Gallai, Annamaria Maddalena Terracciano, Erminia Mannarino, Marco Carotenuto   +18 more
doaj   +1 more source

14‐3‐3γ Protects Against Postoperative Cognitive Dysfunction by Regulating Tau Thr205 Phosphorylation and Synaptic Integrity

Advanced Science, EarlyView.
Integrative multi‐cohort analyses identify 14‐3‐3γ as a biomarker and regulator of cognitive vulnerability. Experimental studies show that 14‐3‐3γ loss is associated with Tau Thr205 phosphorylation, synaptic dysfunction, and cognitive impairment, while genetic overexpression or pharmacological stabilization of 14‐3‐3γ confers protective effects in ...
Shouqiang Zhu, Xue Han, Heng Zhang, Chang Ye, Tianjiao Xia, Xiaoping Gu   +5 more
wiley   +1 more source

Contributions from specific and general factors to unique deficits: two cases of mathematics learning difficulties

Frontiers in Psychology, 2014
Mathematics learning difficulties are a highly comorbid and heterogeneous set of disorders linked to several dissociable mechanisms and endophenotypes.
Vitor Geraldi Haase, Vitor Geraldi Haase, Annelise eJúlio-Costa, Annelise eJúlio-Costa, Júlia Beatriz Lopes-Silva, Júlia Beatriz Lopes-Silva, Isabella eStarling-Alves, Andressa eAntunes, Pedro ePinheiro-Chagas, Guilherme eWood   +9 more
doaj   +1 more source

Trace Elements Genetics: A Potential Role in Treatment‐Resistant Major Psychoses and Related Traits?

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Trace elements are pivotal to key biological processes, with possible effects on psychopathology. We investigated the hypothesis of shared genetic factors between trace elements levels, treatment resistance and related traits. We used genome‐wide summary statistics for trace elements blood concentration, treatment‐resistant depression (TRD ...
Chiara Fabbri, Alessandro Serretti, Marco Menchetti, Benedetta Vai, Francesco Benedetti, Lidia Fortaner‐Uyà, Concetta Crisafulli   +6 more
wiley   +1 more source

Serum BDNF levels in unaffected first-degree relatives of patients with bipolar disorder

Brazilian Journal of Psychiatry, 2016
Objective: Unaffected relatives of bipolar disorder (BD) patients have been investigated for the identification of endophenotypes in an attempt to further elucidate the pathophysiology of the disease.
Fabiano G. Nery, Alexandre D. Gigante, Jose A. Amaral, Francy B. Fernandes, Mariangeles Berutti, Karla M. Almeida, Laura Stertz, Giovana Bristot, Flavio Kapczinski, Beny Lafer   +9 more
doaj   +1 more source

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

British Journal of Clinical Pharmacology, EarlyView.
Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activation of the renin–angiotensin–aldosterone system, sympathetic nervous system ...
Christina Antza, Andrej Belancic, Jens Jordan, Alberto Esteban, Anna Oliveras, Ryan McNally, Panagiota Anyfanti, Jorie Versmissen, María S. Fernández‐Alfonso, Vasilios Kotsis, Thomas Weber, Alexandre Persu, Reinhold Kreutz   +12 more
wiley   +1 more source

Alcoholism: the dissection for endophenotypes

Dialogues in Clinical Neuroscience, 2005
Alcohol dependence (alcoholism) is a complex disorder attributed to the interaction of genetic and environmental factors that form a collage of "disease" predisposition, which is not identical for every alcohol-dependent individual. There is considerable evidence to demonstrate that genetic predisposition accounts for roughly half the risk in the ...
Lisa M, Hines, Lara, Ray, Kent, Hutchison, Boris, Tabakoff   +3 more
openaire   +3 more sources

Altered cortical synchronization in photosensitive idiopathic generalized epilepsy

Epilepsia, EarlyView.
Abstract Objective To characterize cortical excitability and synchronization dynamics in patients with idiopathic generalized epilepsy (IGE) and photosensitivity by assessing steady‐state visual evoked potentials (SSVEPs) elicited by intermittent photic stimulation.
Alessandro Benedetto, Cecilia Steinwurzel, Francesco Turco, Enrica Bonanni, Roberto Cantello, Gionata Strigaro   +5 more
wiley   +1 more source

Endophenotypes and child psychiatry [PDF]

British Journal of Psychiatry, 2001
The search for an appropriate way to define psychiatric phenotypes in order to enhance the discriminative capacity of linkage and association studies is increasingly recognised to be of crucial importance for understanding the genetic basis of both child and adult psychiatry ([Skuse, 1997][1]; [
openaire   +2 more sources

Discovering Endophenotypes for Major Depression [PDF]

Neuropsychopharmacology, 2004
The limited success of genetic studies of major depression has raised questions concerning the definition of genetically relevant phenotypes. This paper presents strategies to improve the phenotypic definition of major depression by proposing endophenotypes at two levels: First, dissecting the depressive phenotype into key components results in narrow ...
Gregor, Hasler, Wayne C, Drevets, Husseini K, Manji, Dennis S, Charney   +3 more
openaire   +2 more sources