Results 11 to 20 of about 16,681 (209)
Neurocognitive Endophenotypes of OCD
, 2021 In this chapter, I address the concept of endophenotypes for obsessive-compulsive disorder (OCD). Endophenotypes are objective and heritable quantitative traits hypothesized to be more biologically tractable than distal clinical phenotypes. This approach has been adopted to gain a better understanding of psychiatric conditions in general.
Vaghi, Matilde M. +2 more
openaire +5 more sources
, 2018 Endophenotypes are traits that, while genetically related to an illness, are not used for diagnoses (e.g., a symptom). It is unlikely that specific genes directly code for any of our current psychiatric diagnoses. Rather, genes influence neurobiological processes that either increase or decrease risk for mental illness.
David C. Glahn +2 more
core +3 more sources
Electrophysiological Endophenotypes for Schizophrenia [PDF]
Harvard Review of Psychiatry, 2016 Endophenotypes are quantitative, heritable traits that may help to elucidate the pathophysiologic mechanisms underlying complex disease syndromes, such as schizophrenia. They can be assessed at numerous levels of analysis; here, we review electrophysiological endophenotypes that have shown promise in helping us understand schizophrenia from a more ...
Owens, Emily M +3 more
openaire +6 more sources
Endophenotypes in psychiatric genetics: Experience of ten years long study (Literature overview) [PDF]
Современная зарубежная психология, 2015 Endophenotypes, as innate characteristics of human organism and psyche, disclosing links with behavioral (psychological) signs in norm and in mental impairments, are regarded as an intermediate link between the action of the gene and its display at the ...
Maryutina T.M.
doaj +1 more source
Evaluating endophenotypes for bipolar disorder
International Journal of Bipolar Disorders, 2021 Background Phenotypic heterogeneity is a major impediment to the elucidation of the neurobiology and genetics of bipolar disorder. Endophenotype could help in reducing heterogeneity by defining biological traits that are more direct expressions of gene ...
Riccardo Guglielmo +2 more
doaj +2 more sources
Psychosis Endophenotypes: A Gene-Set-Specific Polygenic Risk Score Analysis [PDF]
, 2023 BACKGROUND AND HYPOTHESIS: Endophenotypes can help to bridge the gap between psychosis and its genetic predispositions, but their underlying mechanisms remain largely unknown.
van Winkel, Ruud +47 more
core +10 more sources
Adjudicating neurocognitive endophenotypes for schizophrenia
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2006 AbstractAlthough genetic influences on schizophrenia are well established, localization of the genes responsible for this illness has proven extremely difficult. Given evidence that genes predisposing to schizophrenia may be transmitted without expression of the clinical phenotype, efforts have focused on developing endophenotypes.
Burk, Gary +11 more
openaire +5 more sources
TULP4, a novel E3 ligase gene, participates in neuronal migration as a candidate in schizophrenia
CNS Neuroscience &Therapeutics, EarlyView., 2023 Mutations identified from four SCZ pedigrees resulted in decreased TULP4 expression. Tulp4 knockdown caused delayed neuron migration in embryonic mice, and impaired cognition and prepulse inhibition in adult mice. These phenotypes may be related to TULP4 through its involvement in the formation of a novel E3 ubiquitin ligases.
Yan Bi +19 more
wiley +1 more source
Neuromodulation: Technology at the Neural Interface, EarlyView., 2021 Abstract Introduction Deep brain stimulation (DBS) is an effective treatment for refractory obsessive–compulsive disorder (OCD). Neuropsychological assessment contributes to DBS treatment in several ways: it monitors the cognitive safety of the treatment, identifies beneficial or detrimental cognitive side effects and it could aid to explain ...
Tim A. M. Bouwens van der Vlis +7 more
wiley +1 more source
Demographics of analyzed Alzheimer’s disease (AD) endophenotypes.
, 2022 Demographics of analyzed Alzheimer’s disease (AD) endophenotypes.
Anne M. Fagan (7913609) +25 more
core +1 more source