Results 61 to 70 of about 27,716 (308)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2017 oai:ojs2.180.214.246.204:article/5The goal of this work is to design and build a vibration test bench to simulate unbalance in rotating machine. The vibration test bench made of a 25 mm diameter steel shaft and length of 410 mm supported by two ball ...
Maolana, Imam
core +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
An Unbalance Adjustment Method for Development Indicators
, 2013 This paper analyzes some aggregation aspects of the procedure for constructing a composite index on a multidimensional socio-economic phenomenon such as development, the main focus being on the unbalance among individual dimensions.
CASADIO TARABUSI, Enrico, Giulio Guarini
core +1 more source
Sensorless Detection of Mechanical Unbalance in Servodrive with Elastic Coupling
EnergiesThe article focusses on detecting the unbalance of a mechanical component in the electric drive system of a two-mass servomechanism with a permanent magnet synchronous motor (PMSM), which is connected to the load via a long, flexible shaft.
Pawel Ewert +2 more
doaj +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
FEBS Open Bio, EarlyView.14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa +2 more
wiley +1 more source
Energies, 2020 Most often, electrical consumers in the residential and educational sectors are different from industrial electrical consumers. Whereas the vast majority of industrial electrical consumers are low-voltage, three-phase (with three or four wires ...
Gabriel Nicolae Popa +2 more
doaj +1 more source
Unbalance of intestinal microbiota in atopic children [PDF]
BMC Microbiology, 2012 Playing a strategic role in the host immune function, the intestinal microbiota has been recently hypothesized to be involved in the etiology of atopy. In order to investigate the gastrointestinal microbial ecology of atopic disease, here we performed a pilot comparative molecular analysis of the faecal microbiota in atopic children and healthy ...
CANDELA, MARCO +9 more
openaire +6 more sources
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source