Results 61 to 70 of about 3,320,198 (344)

Generalized Active Information: Extensions to Unbounded Domains [PDF]

BIO-Complexity, 2020
In the last three decades, several measures of complexity have been proposed. Up to this point, most of such measures have only been developed for finite spaces. In these scenarios the baseline distribution is uniform. This makes sense because, among other things, the uniform distribution is the measure of maximum entropy over the relevant space ...
Daniel Andrés Díaz-Pachón, Robert J. Marks II   +1 more
openaire   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

On the mean speed of bistable transition fronts in unbounded domains [PDF]

Journal des Mathématiques Pures et Appliquées, 2018
This paper is concerned with the existence and further properties of propagation speeds of transition fronts for bistable reaction-diffusion equations in exterior domains and in some domains with multiple cylindrical branches. In exterior domains we show
Hongjun Guo, F. Hamel, Weijie Sheng
semanticscholar   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

The Algebraic Decay Behavior of Weak Solutions to the Magnetohydrodynamic Equations in Unbounded Domains

Mathematics
This paper investigates the long-term asymptotic behavior of solutions to the initial-boundary value problem for the three-dimensional incompressible viscous magnetohydrodynamic (MHD) equations in general unbounded domains. Addressing the difficulty that
Xuelin Chen, Mingjie Zhang
doaj   +1 more source

Generic convergence of infinite products of nonexpansive mappings with unbounded domains

Frontiers in Applied Mathematics and Statistics, 2015
We study the generic convergence of infinite productsof nonexpansive mappings with unbounded domains in hyperbolic metric spaces.
Simeon eReich, Alexander eZaslavski
doaj   +1 more source

Spectrally adapted physics-informed neural networks for solving unbounded domain problems

Machine Learning: Science and Technology, 2023
Solving analytically intractable partial differential equations (PDEs) that involve at least one variable defined on an unbounded domain arises in numerous physical applications.
Mingtao Xia, Lucas Böttcher, Tom Chou
doaj   +1 more source

A generalized finite difference method based on the Peridynamic differential operator for the solution of problems in bounded and unbounded domains

Computer Methods in Applied Mechanics and Engineering, 2019
In this paper, a generalized finite difference method (GFDM) based on the Peridynamic differential operator (PDDO) is investigated. The weighted moving least square (MLS) procedure involved in the GFDM is replaced by the PDDO.
A. Shojaei, U. Galvanetto, T. Rabczuk, Ali Jenabi, M. Zaccariotto   +4 more
semanticscholar   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

On solutions of elliptic equations with nonpower nonlinearities in unbounded domains

Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2015
The paper highlighted some class of anisotropic elliptic equations of second order in divergence form with younger members with nonpower nonlinearities $$ \sum\limits_{\alpha=1}^{n}(a_{\alpha}({\bf x},u,\nabla u))_{x_{\alpha}}-a_0({\bf x},u,\nabla u)=0. $
Larisa M Kozhevnikova, Anna A Khadzhi
doaj   +1 more source