Results 81 to 90 of about 5,179,634 (396)

Circulating tumor cells in metastatic breast cancer patients treated with immune checkpoint inhibitors – a biomarker analysis of the ALICE and ICON trials

Molecular Oncology, EarlyView.
In this explorative biomarker analysis, we assessed serial sampling of circulating tumor cells (CTCs) with CellSearch in two randomized trials testing immune checkpoint inhibitors (ICIs) in metastatic breast cancer. Our data demonstrate a prognostic potential of CTCs, most apparent 4 weeks into ICI therapy.
Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Elin Borgen, Cecilie Bendigtsen Schirmer, Bjørnar Gilje, Øystein Garred, Jon Lømo, Marius Stensland, Oddmund Nordgård, Ragnhild Sørum Falk, Randi R. Mathiesen, Hege G. Russnes, Jon Amund Kyte, Bjørn Naume   +13 more
wiley   +1 more source

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A Data-Driven Approach to Revolutionize Children’s Vaccination with the Use of VR and a Novel Vaccination Protocol

BioMedInformatics
Background: This study aims to revolutionize traditional pediatric vaccination protocols by integrating virtual reality (VR) technology. The purpose is to minimize discomfort in children, ages 2–12, during vaccinations by immersing them in a specially ...
Stavros Antonopoulos, Manolis Wallace, Vassilis Poulopoulos   +2 more
doaj   +1 more source

Uncertainty principles for the windowed Hankel transform [PDF]

, 2019
The aim of this paper is to prove some new uncertainty principles for the windowed Hankel transform. They include uncertainty principle for orthonormal sequence, local uncertainty principle, logarithmic uncertainty principle and Heisenberg-type uncertainty principle.
arxiv   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Experimental Validation of Finite Element Models for Reinforced Concrete Beams with Discontinuities That Form Dowel-Type Joints

Vibration, 2021
Earthquakes have the highest rate of mortality among the natural disasters and regularly lead to collapsed structures with people trapped inside them. When a reinforced concrete building collapses due to an earthquake, many of the concrete elements (i.e.,
Marios Filippoupolitis, Carl Hopkins
doaj   +1 more source

Germline variants in CDKN2A wild‐type melanoma prone families

Molecular Oncology, EarlyView.
Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen, Marie Loeng, Amalie Lund Holth, Per E. Lønning, Jürgen Geisler, Stian Knappskog   +5 more
wiley   +1 more source

A Direct Eulerian GRP Scheme for the Prediction of Gas-Liquid Two-Phase Flow in HTHP Transient Wells

Abstract and Applied Analysis, 2013
A coupled system model of partial differential equations is presented in this paper, which concerns the variation of the pressure and temperature, velocity, and density at different times and depths in high temperature-high pressure (HTHP) gas-liquid two-
Jiuping Xu, Min Luo, Jiancheng Hu, Shize Wang, Bin Qi, Zhiguo Qiao   +5 more
doaj   +1 more source

Ageing transitions in a network of Rulkov neurons

Scientific Reports, 2022
The phenomenon of ageing transitions (AT) in a Erdős–Rényi network of coupled Rulkov neurons is studied with respect to parameters modelling network connectivity, coupling strength and the fractional ratio of inactive neurons in the network.
Dhrubajyoti Biswas, Sayan Gupta
doaj   +1 more source

Vibration Transmission across Seismically Damaged Beam-to-Column Junctions of Reinforced Concrete Using Statistical Energy Analysis

Vibration, 2023
To detect human survivors trapped in buildings after earthquakes by using structure-borne sound it is necessary to have knowledge of vibration transmission in collapsed and fragmented reinforced-concrete buildings.
Marios Filippoupolitis, Carl Hopkins
doaj   +1 more source