Results 101 to 110 of about 1,482,534 (311)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Inflation Forecast Uncertainty [PDF]

We study the inflation uncertainty reported by individual forecasters in the Survey of Professional Forecasters 1969-2001. Three popular measures of uncertainty built from survey data are analyzed in the context of models for forecasting and asset ...
Soderlind, Paul, Giordani, Paolo
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Decentralized data fusion and active sensing with mobile sensors for modeling and predicting spatiotemporal traffic phenomena [PDF]

, 2012
Uncertainty in Artificial Intelligence - Proceedings of the 28th Conference, UAI 2012163 ...
Low, K.H., Jaillet, P., John Dolan, Sukhatme, G., Jie Chen, Oran, Ali, Chen, Jie, Sukhatme, Gaurav, Ali Oran, Chen, J., Low, Kian Hsiang, Jaillet, Patrick, Patrick Jaillet, Gaurav Sukhatme, Oran, A., Tan, Colin Keng-Yan, Kian Hsiang Low, Colin Keng-yan Tan, Dolan, John, Tan, C.K.-Y., Dolan, J.   +20 more
core  

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

From Non-Maleficence to Beneficence: Expanded Ethical Computing in the Era of Large Language Models

Societies
As modern society grows increasingly complex, access to essential services such as healthcare, legal aid, tailored education, and psychological support remains heavily gated by socio-economic, neurological, and systemic barriers.
Evi Togia, Manolis Wallace, John Liaperdos   +2 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Incidence of Sport-Related Anterior Cruciate Ligament Injuries: An Overview of Systematic Reviews Including 51 Meta-Analyses

Journal of Functional Morphology and Kinesiology
Background/Objectives: The number of systematic reviews evaluating the incidence of anterior cruciate ligament (ACL) injuries in sports is increasing. To synthesize pooled incidence and prevalence rates of sport-related ACL injuries based on published ...
Javier Martinez-Calderon, Marta Infante-Cano, Javier Matias-Soto, Veronica Perez-Cabezas, Alejandro Galan-Mercant, Cristina Garcia-Muñoz   +5 more
doaj   +1 more source