Results 91 to 100 of about 1,482,534 (311)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Impact of Macroeconomic and Financial Uncertainty on GDP Growth: a Quantile Regression Analysis [PDF]
openThis dissertation investigates the relationship between financial and macroeconomic uncertainty and the business cycle. Utilizing quantile regression analysis and US data, the study examines the effects of changes in uncertainty on the entire ...
GJERGJI, GRETA
core
Recent developments in uncertainty evaluation [PDF]
, 2007 The publication in 1993/1995 of the Guide to the Expression of Uncertainty in Measurement, GUM, stimulated a great development of research concerning measurand estimation and uncertainty evaluation.
BICH, WALTER
core
Uncertainty Analysis of Neutron Diffusion Eigenvalue Problem Based on Reduced-order Model
Yuanzineng kexue jishu, 2023 In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model ...
In order to improve the efficiency of core physical uncertainty analysis based on sampling statistics, the proper orthogonal decomposition (POD) and Galerkin projection method were combined to study the application feasibility of reduced-order model based on POD-Galerkin method in core physical uncertainty analysis. The two-dimensional two group TWIGL benchmark question was taken as the research object, the key variation characteristics of the core flux distribution were extracted under the finite perturbation of the group constants of each material region, and the full-order neutron diffusion problem was projected on the variation characteristics to establish a reduced-order neutron diffusion model. The reduced-order model was used to replace the full-order model to carry out the uncertainty analysis of the group constants of the material region. The results show that the bias of the mathematical expectation of keff calculated by reduced-order and full-order models is close to 1 pcm. In addition, compared with the calculation time required for uncertainty analysis of full-order model, the analysis time of reduced-order model (including the calculation time of the full-order model required for the construction of reduced-order model) is only 11.48%, which greatly improves the efficiency of uncertainty analysis. The biases of mathematical expectation of keff calculated by reduced-order and full-order models based on Latin hypercube sampling and simple random sampling are less than 8 pcm, and under the same sample size, the bias from the Latin hypercube sampling result is smaller. From the TWIGL benchmark test results, under the same sample size, Latin hypercube sampling method is more recommended for POD-Galerkin reduced-order model.
doaj
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Journal of Industrial Engineering and Management, 2014 Purpose: The aim of this paper is to deal with the supply chain management (SCM) with quantity discount policy under the complex fuzzy environment, which is characterized as the bi-fuzzy variables.
Zhe Zhang, Jiuping Xu
doaj +1 more source
Fighting Uncertainty with Uncertainty: A Baby Step [PDF]
Theoretical Economics Letters, 2015 We can overcome uncertainty with uncertainty. Using randomness in our choices and in what we control, and hence in the decision making process, could potentially offset the uncertainty inherent in the environment and yield better outcomes. The example we develop in greater detail is the news-vendor inventory management problem with demand uncertainty ...
openaire +3 more sources
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Transport, 2013 The aim of this paper is to deal with the optimal navigation coordinated scheduling (NCS) problem in ship transportation of the Three Gorges Project in China, i.e. the Three Gorges Dam and the Gezhouba Dam. The NCS includes operational scheduling for two
Jiuping Xu +2 more
doaj +1 more source