Results 61 to 70 of about 3,292,975 (323)

EcoEnsemble: A general framework for combining ecosystem models in R

open access: yesMethods in Ecology and Evolution, 2023
Often there are several complex ecosystem models available to address a specific question. However, structural differences, systematic discrepancies and uncertainties mean that they typically produce different outputs.
Michael A. Spence   +2 more
doaj   +1 more source

The Response of Firms' Leverage to Uncertainty: Evidence from UK Public versus Non-Public Firms [PDF]

open access: yes, 2010
This paper empirically investigates the effects of uncertainty on firms' leverage. The analysis is carried out for a large panel of public and non-public UK manufacturing rms over 1999-2008.
Caglayan, M., Rashid, A.
core  

Interstellar Neutral Helium in the Heliosphere from IBEX Observations. I. Uncertainties and Backgrounds in the Data and Parameter Determination Method

open access: yes, 2015
This paper is one of three companion papers presenting the results of our in-depth analysis of the interstellar neutral helium (ISN He) observations carried out using the IBEX-Lo during the first six Interstellar Boundary Explorer (IBEX) observation ...
Bzowski, M.   +10 more
core   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Quantitative Performance Bounds in Biomolecular Circuits due to Temperature Uncertainty [PDF]

open access: yes, 2015
Performance of biomolecular circuits is affected by changes in temperature, due to its influence on underlying reaction rate parameters. While these performance variations have been estimated using Monte Carlo simulations, how to analytically bound them ...
Murray, Richard M., Sen, Shaunak
core  

Uncertainty relation and probability: Numerical illustration

open access: yes, 2010
The uncertainty relation and the probability interpretation of quantum mechanics are intrinsically connected, as is evidenced by the evaluation of standard deviations.
Fujikawa, Kazuo, Umetsu, Koichiro
core   +1 more source

Tightening the uncertainty principle for stochastic currents [PDF]

open access: yes, 2016
We connect two recent advances in the stochastic analysis of nonequilibrium systems: the (loose) uncertainty principle for the currents, which states that statistical errors are bounded by thermodynamic dissipation; and the analysis of thermodynamic ...
Esposito, M.   +2 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

open access: yesMolecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He   +8 more
wiley   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

A Procedure to Perform Multi-Objective Optimization for Sustainable Design of Buildings

open access: yesEnergies, 2016
When dealing with sustainable design concepts in new construction or in retrofitting existing buildings, it is useful to define both economic and environmental performance indicators, in order to select the optimal technical solutions.
Cristina Brunelli   +4 more
doaj   +1 more source

Home - About - Disclaimer - Privacy