Results 101 to 110 of about 35,778 (326)

Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

Malaria Journal, 2019
Background Lactic acidosis with an elevated lactate–pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation.
Hugh W. Kingston, Aniruddha Ghose, Voravut Rungpradubvong, M. Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J. Leopold, Richard J. Maude, Benjamas Intharabut, Sanjib Mohanty, Nicholas P. J. Day, Nicholas J. White, Md Amir Hossain, Nicholas M. Anstey, Arjen M. Dondorp   +14 more
doaj   +1 more source

Toll-like receptor polymorphisms and cerebral malaria: TLR2 Δ22 polymorphism is associated with protection from cerebral malaria in a case control study [PDF]

, 2012
Background In malaria endemic areas, host genetics influence whether a Plasmodium falciparum-infected child develops uncomplicated or severe malaria. TLR2 has been identified as a receptor for P. falciparum-derived glycosylphosphatidylinositol (GPI), and
BT Grimberg, CC John, CC Khor, Chandy C John, CM Johnson, CR Newton, D Kwiatkowski, E Noguchi, FP Mockenhaupt, G Krishnegowda, GE Grau, GE Grau, JA Greene, James W Kazura, Jennifer A Greene, JH Curfs, JJ Yim, JJ Yim, JM Bland, JT DaRe, K Haldar, KJ Livak, LN Henning, NA Sam-Agudu, Nadia Sam-Agudu, Peter A Zimmerman, PY Bochud, Robert O Opoka, S de Kossodo, T Boraska Jelavic, TD Schmittgen, V Amani, V Haehnel   +32 more
core   +1 more source

Dihydroartemisinin-piperaquine for treating uncomplicated Plasmodium falciparum malaria [PDF]

Cochrane Database of Systematic Reviews, 2014
The World Health Organization (WHO) recommends Artemisinin-based Combination Therapy (ACT) for treating uncomplicated Plasmodium falciparum malaria. This review aims to assist the decision-making of malaria control programmes by providing an overview of the relative effects of dihydroartemisinin-piperaquine (DHA-P) versus other recommended ACTs.To ...
Zani, Babalwa, Gathu, Michael, Donegan, Sarah, Olliaro, Piero L, Sinclair, David   +4 more
openaire   +2 more sources

Peripheral Blood Erythrophagocytosis in Plasmodium falciparum Malaria

American Journal of Hematology, EarlyView.
Teresa Almeida, Cristina Avelar Ferreira
wiley   +1 more source

Deep Learning Integration in Optical Microscopy: Advancements and Applications

Microscopy Research and Technique, EarlyView.
It explores the integration of DL into optical microscopy, focusing on key applications including image classification, segmentation, and computational reconstruction. ABSTRACT Optical microscopy is a cornerstone imaging technique in biomedical research, enabling visualization of subcellular structures beyond the resolution limit of the human eye ...
Pottumarthy Venkata Lahari, Sagnika Dutta, H. Deeksha, Samreen A. Patel, Budheswar Dehury, Nirmal Mazumder   +5 more
wiley   +1 more source

Incidence of malaria and efficacy of combination antimalarial therapies over 4 years in an urban cohort of Ugandan children.

PLoS ONE, 2010
BackgroundCombination therapies are now recommended to treat uncomplicated malaria. We used a longitudinal design to assess the incidence of malaria and compare the efficacies of 3 combination regimens in Kampala, Uganda.Methodology/principal ...
Tamara D Clark, Denise Njama-Meya, Bridget Nzarubara, Catherine Maiteki-Sebuguzi, Bryan Greenhouse, Sarah G Staedke, Moses R Kamya, Grant Dorsey, Philip J Rosenthal   +8 more
doaj   +1 more source

Prescriber practices and patient adherence to artemisinin-based combination therapy for the treatment of uncomplicated malaria in Guinea, 2016

Malaria Journal, 2019
Background The World Health Organization recommends the use of artemisinin-based combination therapy (ACT) to treat uncomplicated malaria for the control of malaria across the world.
Alioune Camara, Leah F. Moriarty, Timothée Guilavogui, Papa Sambou Diakité, Joseph Souba Zoumanigui, Sidikiba Sidibé, Ibrahima Bah, Ibrahima Kaba, Djebory Kourouma, Koho Zoumanigui, Mateusz Plucinski   +10 more
doaj   +1 more source

Adherence to a Six-Dose Regimen of Artemether-Lumefantrine for Treatment of Uncomplicated Plasmodium Falciparum Malaria in Uganda. [PDF]

, 2004
Measuring baseline levels of adherence and identifying risk factors for non-adherence are important steps before the introduction of new antimalarials. In Mbarara in southwestern Uganda, we assessed adherence to artemether-lumefantrine (Coartem) in its ...
Bajunirwe, F, Biraro, S, Checchi, F, Fogg, C, Guthmann, J P, Kiguli, J, Kyomugisha, A, Musabe, J, Namiiro, P, Piola, P   +9 more
core   +2 more sources

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

Plasma concentration of parasite DNA as a measure of disease severity in falciparum malaria. [PDF]

, 2014
In malaria-endemic areas, Plasmodium falciparum parasitemia is common in apparently healthy children and severe malaria is commonly misdiagnosed in patients with incidental parasitemia.
Chhaganlal, Kajal D, Day, Nicholas PJ, Dondorp, Arjen M, Faiz, M Abul, Gesase, Samwel, Hendriksen, Ilse CE, Imwong, Mallika, Mishra, Saroj, Mohanty, Sanjib, Mtove, George, Seni, Amir, Veenemans, Jacobien, Verhoef, Hans, White, Nicholas J, Woodrow, Charles J   +14 more
core   +1 more source