Results 111 to 120 of about 19,796 (310)

Treatment of malaria restricted to laboratory-confirmed cases: a prospective cohort study in Ugandan children. [PDF]

, 2007
BACKGROUND: Presumptive treatment of malaria in febrile children is widely advocated in Africa. This may occur in the absence of diagnostic testing or even when diagnostic testing is performed but fails to detect malaria parasites. Such over-treatment of
Staedke, Sarah, Denise Njama-Meya, Tamara D Clark, Moses R Kamya, Sarah Staedke, Nzarubara, Bridget, Njama-Meya, Denise, Clark, Tamara D, Grant Dorsey, Dorsey, Grant, Bridget Nzarubara, Kamya, Moses R   +11 more
core   +1 more source

Deubiquitinase USP38 Stabilizes PLK1 Expression to Boost DNA Damage Repair in Ovarian Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ovarian cancer (OC) is one of the most prevalent and severe gynecological malignant tumors. DNA damage repair (DDR) is essential in maintaining genome stability. This study aims to investigate the effects and mechanisms of USP38 and PLK1 on DNA damage repair and malignant behavior in OC cells.
Yuan Ma, Ying Li, Kai‐Li Li
wiley   +1 more source

IL4 gene polymorphism and previous malaria experiences manipulate anti-Plasmodium falciparum antibody isotype profiles in complicated and uncomplicated malaria

Malaria Journal, 2009
Background The IL4-590 gene polymorphism has been shown to be associated with elevated levels of anti-Plasmodium falciparum IgG antibodies and parasite intensity in the malaria protected Fulani of West Africa. This study aimed to investigate the possible
Kalambaheti Thareerat, Hayano Masashi, Perlmann Hedvig, Tangteerawatana Piyatida, Troye-Blomberg Marita, Khusmith Srisin   +5 more
doaj   +1 more source

Correct Dosing of Artemether-Lumefantrine for Management of Uncomplicated Malaria in Rural Tanzania: Do facility and Patient Characteristics Matter? [PDF]

, 2013
Use of artemisinin-based combination therapy (ACT), such as artemether-lumefantrine (AL), requires a strict dosing schedule that follows the drugs' pharmacokinetic properties.
Amuri, Baraka, de Savigny, Don, Kachur, S. Patrick, Irene M Masanja, Kajungu, Dan, Dan Kajungu, S Kachur, Selemani, Majige, Khatib, Rashid A., Kuepfer, Irene, Jacek Skarbinski, Rashid A Khatib, Kachur, S Patrick, Irene Kuepfer, Masanja, Irene M, Skarbinski, Jacek, Baraka Amuri, Don de Savigny, Masanja, Irene M., Majige Selemani, Khatib, Rashid A   +20 more
core   +1 more source

Chlorproguanil‐dapsone (LAPDAP) for uncomplicated falciparum malaria [PDF]

Tropical Medicine & International Health, 2001
The synergistic antifolate combination of chlorproguanil with dapsone (CPG–DDS; LAPDAP) is being developed by a public–private partnership as a low‐cost treatment for uncomplicated falciparum malaria. LAPDAP is rapidly eliminated from the body, giving it low selection pressure for drug resistance.
openaire   +2 more sources

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

World Antimalarial Resistance Network (WARN) III: Molecular markers for drug resistant malaria [PDF]

, 2007
Molecular markers for drug resistant malaria represent public health tools of great but mostly unrealized potential value. A key reason for the failure of molecular resistance markers to live up to their potential is that data on the their prevalence is ...
Sibley, CH, Happi Christian T, Mbacham, W, Mugittu, K, Sutherland Colin J, Zimmerman, Peter A., Joshi, HH, Barnwell, JW, Naidoo, I, Happi, Christian T., Sutherland, Colin J, Sibley Carol H, Price Ric N, Mbacham, Wilfred, Happi, Christian T, Rosenthal Philip J, Barnwell, John W., Meshnick, Steven R, Shafer, RW, Plowe, CV, Roper, Cally, Zimmerman, PA, Sibley, Carol Hopkins, Shafer, Robert W, Barnwell John W, Barnwell, John W, Meshnick Steven R, Shafer, Robert W., Naidoo Inbarani, Sibley, Carol H, Joshi, Hema H., Sutherland, CJ, Meshnick, SR, Shafer Robert W, Rosenthal, Phillip J., Happi, CT, Rosenthal, PJ, Plowe Christopher V, Joshi, Hema H, Plowe, Christopher V., Rosenthal, Philip J, Mugittu Kefas, Roper Cally, Meshnick, Steven R., Zimmerman, Peter A, Sutherland, Colin J., Price, Ric N., Plowe, Christopher V, Mugittu, Kefas, Mbacham Wilfred, Naidoo, Inbarani, Price, RN, Price, Ric N, Zimmerman Peter A, Roper, C, Joshi Hema H   +55 more
core   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

Effectiveness of a community intervention on malaria in rural Tanzania - a randomised controlled trial. [PDF]

, 2010
BACKGROUND: Malaria infections are a major public health problem in Africa and prompt treatment is one way of controlling the disease and saving lives.
Warsame, M, Tomson, G., Müller, O., Gustafsson, LL, Kouyaté, B., Warsame, M., Jahn, A, Nsimba, S., Jahn, A., Müller, O, Eriksen, J, Eriksen, J., Nsimba, S, Mujinja, P., Gustafsson, L L, Sauerborn, R., Tomson, G, Gustafsson, L.L., Sauerborn, R, Mujinja, P, Kouyaté, B   +20 more
core   +1 more source

Using art history to explore society's changing connections with agriculture

PLANTS, PEOPLE, PLANET, EarlyView.
Food insecurity is a looming challenge that especially affects those least fortunate. Consumer food choices have a substantial impact on the sustainability of current food systems. Here, we use art as a lens through which to consider our contemporary and historical relationship to one of the world's most crucial crops, the potato, in the context of the
Edward F. Hill‐King, Martin R. McAinsh, Michael R. Roberts   +2 more
wiley   +1 more source