Results 101 to 110 of about 19,796 (310)

Randomised trial of chloroquine/sulphadoxine-pyrimethamine in Gambian children with malaria: impact against multidrug-resistant P. falciparum. [PDF]

, 2006
OBJECTIVES: In the Gambia, the combination of chloroquine (CQ) and sulphadoxine-pyrimethamine (SP) has replaced CQ monotherapy for treatment of malaria caused by Plasmodium falciparum. We measured the efficacy of the combination CQ/SP, and the prevalence
Targett Geoffrey A. T, Sutherland Colin J, Samuel Dunyo, Jawara, Musa, Coleman, Rosalind, Alexander Neal, Mesa, Eduardo, Sutherland, Colin J, Hallett, Rachel, Rachel Hallett, Ord Rosalynn, Coleman Rosalind, Musa Jawara, Geoffrey A. T Targett, Pinder Margaret, Jawara Musa, Ord, Rosalynn, Walraven, Gijs, Sowe, Maimuna, Targett, Geoffrey AT, Eduardo Mesa, Dunyo, Samuel, Neal Alexander, Colin J Sutherland, Rosalind Coleman, Gijs Walraven, Sowe Maimuna, Walraven Gijs, Mesa Eduardo, Alexander, Neal, Margaret Pinder, Dunyo Samuel, Rosalynn Ord, Maimuna Sowe, Pinder, Margaret, Hallett Rachel   +35 more
core   +1 more source

Asymptomatic recrudescence after artemether-lumefantrine treatment for uncomplicated falciparum malaria: a systematic review and meta-analysis [PDF]

, 2020
Background In clinical trials of therapy for uncomplicated Plasmodium falciparum, there are usually some patients who fail treatment even in the absence of drug resistance.
Okell, Lucy C, Mumtaz, Rida, Challenger, Joseph   +2 more
core   +1 more source

Transcriptomic signatures reveal systemic adaptations and immune modulation in response to training and competitive racing in horses

Equine Veterinary Journal, EarlyView.
Abstract Background The molecular mechanisms underlying adaptation to physical exertion and racing stress in horses remain incompletely understood. Peripheral blood transcriptomics offers a minimally invasive method to monitor systemic responses to exercise and identify biomarkers of adaptation or overload. Objectives To evaluate transcriptomic changes
Izabela Dąbrowska, Jowita Grzędzicka‐Agko, Paula Kiełbik, Michał Trela, Olga Witkowska‐Piłaszewicz   +4 more
wiley   +1 more source

Does reduced oxygen delivery cause lactic acidosis in falciparum malaria? An observational study

Malaria Journal, 2019
Background Lactic acidosis with an elevated lactate–pyruvate ratio suggesting anoxia is a common feature of severe falciparum malaria. High lactate levels are associated with parasitized erythrocyte sequestration in the microcirculation.
Hugh W. Kingston, Aniruddha Ghose, Voravut Rungpradubvong, M. Trent Herdman, Katherine Plewes, Haruhiko Ishioka, Stije J. Leopold, Richard J. Maude, Benjamas Intharabut, Sanjib Mohanty, Nicholas P. J. Day, Nicholas J. White, Md Amir Hossain, Nicholas M. Anstey, Arjen M. Dondorp   +14 more
doaj   +1 more source

Revolutionizing Healthcare With Paper‐Based Nucleic Acid Testing

Exploration, EarlyView.
This work summarizes strategies to enhance paper‐based devices for nucleic acid testing. Key approaches include optimizing paper platforms, improving nucleic acid amplification, and refining labeling/signaling methods. These advancements aim to boost sensitivity, speed, and usability, making paper‐based diagnostics more effective for point‐of‐care ...
Hong Zhang, Yi Yang, Heng Li, Xiaolin Hu, Hui Xiao, Dou Wang, Sergio Benardini, Wei Gu, Yang Luo   +8 more
wiley   +1 more source

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Malaria Rapid Testing by Community Health Workers is Effective and Safe for Targeting Malaria Treatment: Randomised Cross-over Trial in Tanzania. [PDF]

, 2011
Early diagnosis and prompt, effective treatment of uncomplicated malaria is critical to prevent severe disease, death and malaria transmission. We assessed the impact of rapid malaria diagnostic tests (RDTs) by community health workers (CHWs) on ...
Petzold, M.G, Ka¨ llander, K., Max G. Petzold, Gustafsson, Lars L, Marian Warsame, Massele Amos, Källander, K,, Lars L Gustafsson, Gustafsson Lars L., Mubi, M., Massele, Amos, Max G Petzold, Premji, Z., Tomson, G, Björkman, Anders, Marycelina Mubi, Amos Massele, Premji, Zul, Ngasala Billy, Maganga, G., Karin Källander, Maganga, G,, Mubi, Marycelina, Anders Björkman, Warsame, M,, Warsame, M., Ngasala, Billy, Petzold Max G., Maganga, Gloria, Kallander, K., Björkman Anders, Zul Premji, Mårtensson, Andreas, Tomson, G., Martensson, A., Bjorkman, A., Ngasala, B., Mårtensson, A,, Petzold, Max G, Ngasala, B,, Göran Tomson, Tomson, Göran, Tomson Göran, Massele, A., Mårtensson Andreas, Lars L. Gustafsson, Massele, A,, Petzold, M.G., Bjo¨rkman, A., Janson, A,, Petzold, M.G,, Premji Zul, Maganga Gloria, Janson, A., Andreas Mårtensson, Gloria Maganga, Warsame, Marian, Gustafsson, L.L, Källander, Karin, Warsame Marian, Källander Karin, Mub, M., Janson Annika, Billy Ngasala, Janson, Annika, Mubi Marycelina, Gustafsson, L.L., Gustafsson, L.L,, Ma°rtensson, A., Annika Janson   +69 more
core   +1 more source

Bayesian Model Averaging in Causal Instrumental Variable Models

Journal of Applied Econometrics, EarlyView.
ABSTRACT Instrumental variables are a popular tool to infer causal effects under unobserved confounding, but choosing suitable instruments is challenging in practice. We propose gIVBMA, a Bayesian model averaging procedure that addresses this challenge by averaging across different sets of instrumental variables and covariates in a structural equation ...
Gregor Steiner, Mark Steel
wiley   +1 more source

Liver Injury in Uncomplicated Malaria is an Overlooked Phenomenon: An Observational StudyResearch in context

EBioMedicine, 2018
Background: Liver injury is a known feature of severe malaria, but is only incidentally investigated in uncomplicated disease. In such cases, drug-induced hepatotoxicity is often thought to be the primary cause of the observed liver injury, and this can ...
Isaie J. Reuling, Gerdie M. de Jong, Xi Zen Yap, Muhammad Asghar, Jona Walk, Lisanne A. van de Schans, Rob Koelewijn, Anna Färnert, Quirijn de Mast, Andre J. van der Ven, Teun Bousema, Jaap J. van Hellemond, Perry J.J. van Genderen, Robert W. Sauerwein   +13 more
doaj   +1 more source

Artemisinin antimalarials: preserving the "magic bullet"

, 2010
The artemisinins are the most effective antimalarial drugs known. They possess a remarkably wide therapeutic index. These agents have been used in traditional Chinese herbal medicine for more then 2,000 years but were not subjected to scientific scrutiny
White, Lisa, Maude, Richard J., Maude, RJ, Richard J. Maude, White, LJ, Woodrow, CJ, White, Lisa J., Charles J. Woodrow, Lisa J. White, Woodrow, Charles J.   +9 more
core   +1 more source