Results 81 to 90 of about 19,796 (310)

Predictive score of uncomplicated falciparum malaria patients turning to severe malaria [PDF]

The Korean Journal of Parasitology, 2007
In acute uncomplicated falciparum malaria, there is a continuum from mild to severe malaria. However, no mathematical system is available to predict uncomplicated falciparum malaria patients turning to severe malaria. This study aimed to devise a simple and reliable model of Malaria Severity Prognostic Score (MSPS).
Noppadon, Tangpukdee, Srivicha, Krudsood, Vipa, Thanachartwet, Chatnapa, Duangdee, Siriphan, Paksala, Putza, Chonsawat, Siripan, Srivilairit, Sornchai, Looareesuwan, Polrat, Wilairatana   +8 more
openaire   +2 more sources

A narrow bandgap Schottky heterojunction Fe2N/CeO2 microneedle triggering sonodynamic reactive oxygen species storm for drug‐resistance‐free skin fungal infection

BMEMat, EarlyView.
Inorganic sonosensitizers suffer from inefficient electron‐hole separation, rapid recombination, and wide bandgaps in anti‐fungal applications. We propose MN@Fe2N/CeO2 to directly eliminate fungi without drug resistance. Combining semiconductor CeO2's advantages with Fe2N's high work function and activity enables efficient Schottky heterojunctions ...
Li Wang, Jiayi Yang, Ning Tang, Youbin Zheng, Yichao Hou, Chutong Liu, Lihao Guo, Yingying Liao, Gandong Zhou, Weiwei Wu, Xin Du, Shuxiang Xu, Jie Yin, Miaomiao Yuan   +13 more
wiley   +1 more source

Haptoglobin gene diversity and incidence of uncomplicated malaria among children in Iganga, Uganda

Malaria Journal, 2020
Background Haptoglobin (Hp) is an acute phase protein that takes part in systemic regulation of haem during Plasmodium falciparum infections. Numerous genotypes of haptoglobin have been reported in malaria endemic populations.
Catherine N. Lwanira, Fred Kironde, Göte Swedberg   +2 more
doaj   +1 more source

Persistence of chloroquine-resistant haplotypes of Plasmodium falciparum in children with uncomplicated Malaria in Lagos, Nigeria, four years after change of chloroquine as first-line antimalarial medicine. [PDF]

, 2015
BACKGROUND: In Nigeria, despite the change in National malaria drug policy to artemisinin combination therapy (ACT) in 2005 due to widespread chloroquine resistance, chloroquine (CQ) is still widely used in the treatment of malaria because it is cheap ...
Sutherland, Colin J, Oladipo, Oladosu O, Wellington, Oyibo A   +2 more
core   +1 more source

Spotlight on the Nucleotide: Solid‐State NMR for the Investigation of ATP Hydrolysis in the ATPase SmsC

Chemistry – A European Journal, EarlyView.
Nucleotide‐detected solid‐state NMR has been applied to probe nucleotide conformations and dynamics during ATP hydrolysis using the dimeric P‐loop ATPase SmsC as a model protein. The different stages of ATP hydrolysis have been mimicked by ATP analogues for which different degrees of conformational heterogeneity have been observed. ABSTRACT Solid‐state
Nina Wehr, Laure Decamps, Julius Schlüter, Koen Linssen, Georg Künze, Kushal Sengupta, Serena DeBeer, Thomas Wiegand   +7 more
wiley   +1 more source

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

Clinical pharmacokinetics of quinine and its relationship with treatment outcomes in children, pregnant women, and elderly patients, with uncomplicated and complicated malaria: a systematic review

Malaria Journal, 2022
Background Standard dosage regimens of quinine formulated for adult patients with uncomplicated and complicated malaria have been applied for clinical uses in children, pregnant women, and elderly.
Teerachat Saeheng, Kesara Na-Bangchang
doaj   +1 more source

Prospective evaluation of artemether-lumefantrine for the treatment of non-falciparum and mixed-species malaria in Gabon [PDF]

, 2012
Background: The recommendation of artemisinin combination therapy (ACT) as first-line treatment for uncomplicated falciparum malaria is supported by a plethora of high quality clinical trials.
Mesküre Capan, Kurth, Florian Michael, Michael Ramharter, Kurth, F., Capan, Mesküre, Fanny Joanny, Arti Basra, Mombo-Ngoma, G., Capan, M., Capan Melser, Mesküre, Adegnika, A.A., Florian Kurth, Adegnika, Ayôla Akim, Adegnika, Ayola A., Ayola A Adegnika, Kremsner, Peter, Diop, D.A., Kremsner, P.G., Würbel, Heike, Kleine, C., Basra, Arti, Kleine, Christian, Ghyslain Mombo-Ngoma, Sabine Bélard, Joanny, F., Ramharter, M., Heike Würbel, Benjamin Mordmüller, Joanny, Fanny, Mombo-Ngoma, Ghyslain, Peter G Kremsner, Akerey-Diop, Daisy, Kremsner, Peter G., Daisy A Diop, Wurbel, H., Mordmüller, Benjamin Gottlieb, Christian Kleine, Belard, S., Ramharter, Michael, Basra, A., Bélard, Sabine, Kurth, Florian, Diop, Daisy A., Mordmuller, B.   +43 more
core   +1 more source

Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria [PDF]

Clinical and Vaccine Immunology, 2016
ABSTRACT Lymphocytes are implicated in immunity and pathogenesis of severe malaria. Since lymphocyte subsets vary with age, assessment of their contribution to different etiologies can be difficult. We immunophenotyped peripheral blood from Malawian children presenting with cerebral malaria, severe malarial anemia, and ...
Mandala, WL, Msefula, CL, Gondwe, EN, Gilchrist, JJ, Graham, SM, Pensulo, P, Mwimaniwa, G, Banda, M, Taylor, TE, Molyneux, EE, Drayson, MT, Ward, SA, Molyneux, ME, MacLennan, CA   +13 more
openaire   +5 more sources

Radical Listening as a Governance Innovation: Integrating Planetary Health and Community‐Led Forest Conservation in Indonesia

Environmental Policy and Governance, EarlyView.
ABSTRACT While REDD+ prioritizes carbon sequestration, its narrow focus often overlooks forest‐health linkages critical to community well‐being. This paper examines the holistic model of Health in Harmony (HIH) and Alam Sehat Lestari (ASRI), which integrates forest conservation with healthcare through radical listening—a decolonial community engagement
Angie Hsu, Nur Febriani, Luce Alvafritz, Firdani Asri   +3 more
wiley   +1 more source