Results 71 to 80 of about 19,796 (310)

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

In-vivo efficacy of amodiaquine-artesunate in children with uncomplicated Plasmodium falciparum malaria in western Kenya.

, 2009
OBJECTIVES: To assess the efficacy of amodiaquine-artesunate in an area with high chloroquine resistance in western Kenya. METHODS: Twenty-eight day in-vivo efficacy trial of amodiaquine-artesunate in 103 children aged 6-59 months in western Kenya with ...
Thwing, JI, Slutsker, L, Odero, CO, McMorrow, M, Hamel, MJ, Desai, M, Odhiambo, FO, Otieno, KO, Kariuki, S, Roper, C, Vulule, J, Newman, RD, Ord, R   +12 more
core   +1 more source

Review: Provider practice and user behavior interventions to improve prompt and effective treatment of malaria: do we know what works? [PDF]

, 2009
Effective case management of uncomplicated malaria is a cornerstone of successful malaria control. With current calls for the global elimination of malaria, all strategies to control malaria need to reach the highest achievable level of effective ...
Webster, Jayne, Smith, Lucy A, Jones, Caroline, Meek, Sylvia   +3 more
core   +1 more source

Drugs for treating uncomplicated malaria in pregnant women [PDF]

Cochrane Database of Systematic Reviews, 2008
Women are more vulnerable to malaria during pregnancy, and malaria infection may have adverse consequences for the fetus. Identifying safe and effective treatments is important.To compare the effects of drug regimens for treating uncomplicated falciparum malaria in pregnant women.We searched the Cochrane Infectious Diseases Group Specialized Register ...
Lois C, Orton, Aika A A, Omari
openaire   +2 more sources

Failures in the case management of children with uncomplicated malaria in Bata district of Equatorial Guinea and associated factors.

PLoS ONE, 2019
BackgroundIn Equatorial Guinea, malaria continues to be one of the main causes of morbidity and mortality among children. The National Therapeutic Guide established artesunate-amodiaquine (ASAQ) as first-line treatment for uncomplicated malaria, but ...
Pablo Suárez-Sánchez, Belén García, Jesús Nzang, Policarpo Ncogo, Matilde Riloha, Pedro Berzosa, Agustín Benito, María Romay-Barja   +7 more
doaj   +1 more source

A randomized clinical trial comparing safety, clinical and parasitological response to artemether-lumefantrine and chlorproguanil-dapsone in treatment of uncomplicated malaria in pregnancy in Mulago hospital, Uganda

Journal of Infection in Developing Countries, 2008
Background: Malaria infection during pregnancy is a major public health problem. Due to increasing resistance to Chloroquine and Sulphadoxine/Pyrimethamine, the Ugandan national policy on malaria treatment was changed in 2005 to Artemisinin-based ...
Daniel Kabonge Kaye, Ruth Nshemerirwe, Twaha Serunjogi Mutyaba, Grace Ndeezi   +3 more
doaj   +1 more source

Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria : a systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data [PDF]

, 2015
Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with artemether-lumefantrine efficacy.
Mårtensson, A, Sibley, CH, Nsanzabana, C, Bassat, Q, Ringwald, P, Faucher, JF, WorldWide Antimalarial Resistance Network Lumefantrine PK/PD Stu,, Ashley, EA, Hodel, EM, Lindegardh, NL, Davis, TME, Schramm, B, Lefèvre, G, Parikh, S, Mayxay, M, Van Vugt, M, Borrmann, S, McGready, R, Hamed, K, Jullien, V, Workman, LJ, Newton, PN, Stepniewska, K, Vugt, MV, Genton, B, Kiechel, JR, Rombo, L, White, Nicholas, Price, Richard, Kofoed, PE, Piola, P, Barnes, KI, Dahal, P, Aweeka, F, Moreira, C, Tarning, J, Nosten, F, Djimde, AA, Ursing, J, Ngasala, BE, Deloron, P, Karunajeewa, HA, Guérin, PJ, Denis, MB, Marsh, K, WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group, Price, RN, Lindegardh, N, White, NJ, Huang, L, McGready, Rose   +50 more
core   +1 more source

Pearl's causality for integrating ecological datasets: A case study on Myricaria germanica in northern Italy

Applications in Plant Sciences, EarlyView.
Abstract Premise Applied ecology can significantly influence policy decisions on environmental issues. Therefore, research in this field should be as transparent and reproducible as possible. Existing expertise from a broad range of disciplines should also be integrated into ecological research to allow researchers to maximize understanding of complex ...
Kailin Weitkämper, Kilian Rückschloß, Tommaso Sitzia, Bruno Michielon, Silke Werth, Felix Weitkämper   +5 more
wiley   +1 more source

Elevated plasma von Willebrand factor and propeptide levels in Malawian children with malaria. [PDF]

PLoS ONE, 2011
In spite of the significant mortality associated with Plasmodium falciparum infection, the mechanisms underlying severe disease remain poorly understood.
Happy T Phiri, Daniel J Bridges, Simon J Glover, Jan A van Mourik, Bas de Laat, Bridon M'baya, Terrie E Taylor, Karl B Seydel, Malcolm E Molyneux, E Brian Faragher, Alister G Craig, James E G Bunn   +11 more
doaj   +1 more source

Efficacy and safety of dihydroartemisinin-piperaquine for treatment of Plasmodium vivax malaria in endemic countries: meta-analysis of randomized controlled studies [PDF]

, 2013
Background: This study aimed to synthesize available evidence on the efficacy of dihydroartemisinin-piperaquine (DHP) in treating uncomplicated Plasmodium vivax malaria in people living in endemic countries.
Cho Naing (492196), Vanessa Racloz (321919), Marcel Tanner (33894), Maxine Anne Whittaker (492197), Joon Wah Mak, Aung Kyan, Marcel Tanner, Naing, Cho, Maxine Anne Whittaker, Cho Naing, Naing Cho, Racloz, Vanessa, Racloz Vanessa, Whittaker, Maxine Anne, Vanessa Racloz, Joon Wah Mak (207190), Kyan Aung, Tanner, Marcel, Mak, Joon Wah, Mak Joon Wah, Simon Andrew Reid, Simon Andrew Reid (492199), Reid, Simon Andrew, Tanner Marcel, Reid Simon Andrew, Aung, Kyan, Whittaker Maxine Anne, Kyan Aung (492198)   +27 more
core   +1 more source