Results 231 to 240 of about 127,036 (330)

Move beyond free radical theory of aging

iMetaOmics, EarlyView.
Free radicals play a dual, dose‐dependent role in aging. Low levels activate the key sensor adenosine 5'‐monophosphate‐activated protein kinase (AMPK), promoting cell survival mechanisms like autophagy and enhancing mitochondrial health. High levels, however, push AMPK to initiate cell death pathways, such as apoptosis. This positions AMPK as a central
Xiaofeng Dai, Meilan Hu, Ruohan Lyu
wiley   +1 more source

Uncoupling protein-1 expression does not protect mice from diet-induced obesity.

Am J Physiol Endocrinol Metab, 2021
Wang H, Willershäuser M, Li Y, Fromme T, Schnabl K, Bast-Habersbrunner A, Ramisch S, Mocek S, Klingenspor M.   +8 more
europepmc   +1 more source

Brown fat in obesity: Uncoupling protein-1 versus thermogenic activity [PDF]

Temperature, 2017
openaire   +2 more sources

Investigating Uncoupling Protein 1 Mechanisms Using Molecular Dynamics Simulations

Fedme og fedmerelaterede sygdomme er stigende byrder både for individer og samfundet og omtales nu ofte som en pandemi. Over de sidste par årtier er brunt fedtvæv blevet anerkendt som et muligt farmakologisk mål for fedmebehandling på grund af dets unikke evne til at øge stofskiftehastigheden og glukoseoptag. Uncoupling protein 1 (UCP1) er ansvarligfor
openaire   +2 more sources

Targeting GRP78 and the Proteostasis Network to Break the Therapeutic Ceiling in Neuroendocrine Prostate Cancer

iNew Medicine, EarlyView.
ABSTRACT HSPA5 (also known as GRP78/BiP) is a master regulator of the endoplasmic reticulum (ER) stress response and a key node in the proteostasis network. In neuroendocrine prostate cancer (NEPC), an aggressive, therapy‐refractory lineage that emerges under pressure from androgen receptor (AR) directed therapies, GRP78 is upregulated and co‐opted to ...
Amos Olalekan Akinyemi, Md Rakibul Alam, Mithu Howlader, Mohammad Esfini Farahani, Lixiang Gu, Chun Li, Chripus Ngule, Kevin Fulp, Bolaji Owoyemi, Xinyi Wang, Samuel Nwadialo, Fatemeh Selani, Makumba Esoe, Obaleye Oluwafunminiyi, Zhiguo Li   +14 more
wiley   +1 more source

Uncoupling protein 1-driven Cre (Ucp1-Cre) is expressed in the epithelial cells of mammary glands and various non-adipose tissues. [PDF]

Mol Metab
Kim K, Wann J, Kim HG, So J, Rosen ED, Roh HC.   +5 more
europepmc   +1 more source

Expression, Folding, and Proton Transport Activity of Human Uncoupling Protein-1 (UCP1) in Lipid Membranes

, 2013
Tuan Hoang, Matthew D. Smith, Masoud Jelokhani‐Niaraki   +2 more
openalex   +1 more source

Schisantherin A: Remodeling Gut Microbiota to Activate the Gut–Immune–Neural–Adipose Axis for Thermogenesis

iNew Medicine, EarlyView.
ABSTRACT The global obesity epidemic necessitates safe and effective strategies to enhance energy expenditure. Schisantherin A (Sin A), a lignan derived from Schisandra chinensis, has demonstrated metabolic benefits, yet its systemic mechanism remains unclear.
Ling Yin
wiley   +1 more source

Thymus Uncoupling Protein 1 Is Exclusive to Typical Brown Adipocytes and Is Not Found in Thymocytes [PDF]

, 2006
Andrea Frontini, Sophie Rousset, Anne‐Marie Cassard, Cristina M. Zingaretti, Daniel Ricquier, Saverio Cinti   +5 more
openalex   +1 more source

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source