Results 291 to 300 of about 127,036 (330)

TbTim20 facilitates protein import at a low membrane potential in trypanosomes lacking the mitochondrial genome

The FEBS Journal, EarlyView.
Protein import into mitochondria relies on TIM complexes and the membrane potential. Trypanosoma brucei has a unique TIM complex, and the role of one subunit, TbTim20, has remained unclear. Here, we show that TbTim20 is essential in cells lacking mitochondrial DNA. The importance of TbTim20 increases as the membrane potential decreases.
Corinne von Känel, Salome Aeschlimann, Michaela Husová, Silke Oeljeklaus, Philip Stettler, Achim Schnaufer, Bettina Warscheid, Alena Zíková, André Schneider   +8 more
wiley   +1 more source

Effect of Tailor-Made Diet on Weight Loss in Obese Japanese Patients of Type 2 Diabetes Mellitus with Single Nucleotide Polymorphisms in β3-Adrenergic Receptor, Uncoupling Protein 1 or β2-Adrenergic Receptor Genes

, 2008
Saeko Imai, Chikako Togawa, Toyomi Yamamura, Kayoko Oyabu, Saori Fujimoto, Mikuko Matsuda, Hana Kozai, Kanji Watanabe, Schuichi Miyatani, Shizuo Kajiyama   +9 more
openalex   +1 more source

Hepatic GCGR is required for the superior weight loss and metabolic effects of a structurally related analogue of the dual GCGR/GLP‐1R agonist survodutide in mice

Diabetes, Obesity and Metabolism, EarlyView.
Fen Long, Tenagne D. Challa, Vissarion Efthymiou, Manuel Klug, Thomas Klein, Heike Neubauer, Christian Wolfrum, Carla Horvath   +7 more
wiley   +1 more source

Expression of uncoupling protein 1 in bovine muscle tissues.

Expression of uncoupling protein 1 in bovine muscle tissues.
openaire  

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Pig has no uncoupling protein 1

Biochemical and Biophysical Research Communications, 2017
Brown adipose tissue (BAT) is critical for mammal's survival in the cold environment. Uncoupling protein 1 (UCP1) is responsible for the non-shivering thermogenesis in the BAT. Pig is important economically as a meat-producing livestock. However, whether BAT or more precisely UCP1 protein exists in pig remains a controversy. The objective of this study
Lianjie Hou, Jia Shi, Lingbo Cao, Guli Xu, Chingyuan Hu, Chong Wang   +5 more
openaire   +2 more sources

Uncoupling protein 1 expression and high-fat diets

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 2011
Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as heat. Cold exposure not only activates Ucp1-mediated thermogenesis to maintain normothermia but also results in adaptive thermogenesis, i.e., the recruitment of thermogenic ...
Tobias, Fromme, Martin, Klingenspor
openaire   +2 more sources

Uncoupling Proteins 1 and 3 Are Regulated Differently

Biochemistry, 2000
Using a heterologous yeast expression system, we have previously found a marked discordance between the effects of uncoupling protein (UCP) 1 and UCP3L on basal O(2) consumption in whole yeast versus isolated mitochondria. In whole yeast, UCP3L produces a greater stimulation of basal O(2) consumption, while in isolated mitochondria, UCP1 produces a ...
T, Hagen, C Y, Zhang, C R, Vianna, B B, Lowell   +3 more
openaire   +2 more sources

A mitochondrial uncoupling artifact can be caused by expression of uncoupling protein 1 in yeast

Biochemical Journal, 2001
Uncoupling protein 1 (UCP1) from mouse was expressed in yeast and the specific (GDP-inhibitable) and artifactual (GDP-insensitive) effects on mitochondrial uncoupling were assessed. UCP1 provides a GDP-inhibitable model system to help interpret the uncoupling effects of high expression in yeast of other members of the mitochondrial carrier protein ...
J A, Stuart, J A, Harper, K M, Brindle, M B, Jekabsons, M D, Brand   +4 more
openaire   +2 more sources

Insulin-like Growth Factor Type 1 Upregulates Uncoupling Protein 3

Biochemical and Biophysical Research Communications, 2001
In this study the expression of uncoupling protein 3 (UCP3) and its regulation by insulin-like growth factor 1 (IGF-I) and insulin in human neuroblastoma SH-SY5Y cells were characterized. Reverse transcriptase-PCR, Western blot, and immunofluorescence analysis showed that SH-SY5Y cells express UCP3 natively.
H, Gustafsson, L, Adamson, J, Hedander, E, Walum, A, Forsby   +4 more
openaire   +2 more sources

Uncoupling protein 1 contributes to fat-reducing effect of leptin

Obesity Research & Clinical Practice, 2007
Leptin is proposed to reduce body fat by increasing energy expenditure, in addition to decreasing food intake, through the activation of brown adipose tissue (BAT) thermogenesis. To confirm this, we investigated the effects of leptin on whole body energy expenditure, BAT functions and adiposity in wild-type (WT) mice, and compared with those in mice ...
Yuko, Okamatsu-Ogura, Akihiro, Uozumi, Chitoku, Toda, Kazuhiro, Kimura, Hitoshi, Yamashita, Masayuki, Saito   +5 more
openaire   +2 more sources