Results 291 to 300 of about 1,699,867 (343)
A Novel UPF1 Variant Associated With a Rare UPF1‐Related Neurodevelopmental Disorder
Clinical Genetics, EarlyView.Nonsense‐mediated mRNA decay (NMD) plays a crucial role in degrading aberrant transcripts with premature termination codons, and aberrant NMD has been linked to neurodevelopmental disorders (NDD). A key player of NMD is UPF1, which is a helicase. Including the current patient, only four individuals with NDD and UPF1 variants have been reported in the ...
Zeynep Tümer +4 more
wiley +1 more source
Cell Proliferation, EarlyView.tRF‐3a is the main tsRNA subtype up‐regulated in HBV‐related HCC. tRF‐3a‐Pro is significantly up‐regulated in HBV‐related HCC tumour than that in paratumour tissues. The level of tRF‐3a‐Pro in serum is a promising candidate biomarker for HCC diagnosis. tRF‐3a‐Pro promotes cell proliferation and regulates cell cycle of HCC.
Jingyi Si +7 more
wiley +1 more source
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Cell Proliferation, EarlyView.One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye +6 more
wiley +1 more source
Cell Proliferation, EarlyView.Transcriptional and translational characteristics during goat oocyte maturation and identification of key factors, including GTPBP4, for prepubertal goat oocyte maturation. ABSTRACT The intricate mechanisms driving oocyte maturation remain only partially understood, especially within the domains of domestic animal reproduction and translational ...
Jianpeng Qin +21 more
wiley +1 more source
Quercetin Upregulates Uncoupling Protein 1 in White/Brown Adipose Tissues through Sympathetic Stimulation (J Obes Metab Syndr 2018;27:102-9). [PDF]
J Obes Metab Syndr, 2019 Lee SK.
europepmc +2 more sources
European Journal of Clinical Investigation, EarlyView.This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone +28 more
wiley +1 more source
FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries
The FEBS Journal, EarlyView.This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio +9 more
wiley +1 more source
Adverse impact of acute Toxoplasma gondii infection on human spermatozoa
The FEBS Journal, EarlyView.Toxoplasma gondii tachyzoites injected intraperitoneally crossed the blood‐testes barrier, appearing in testes/epididymis by day 6 post‐infection. In vitro exposure caused increased sperm necrosis/apoptosis and structural damage to heads/tails. Immunofluorescence and SEM revealed tachyzoites attaching to sperm tails, inducing twisting/detachment, and ...
Lisbeth Rojas‐Barón +11 more
wiley +1 more source