Results 111 to 120 of about 614,915 (288)

The Importance of Accurately Determining the Underlying Cause of Death in a Causal Chain Situation. Effects on Legal Liability. Essential Role of Forensic Investigation in Determining the Underlying Cause [PDF]

Claudiu-Gabriel Galu
openalex   +1 more source

Twenty-year changes in mortality rates and underlying causes of death in patients with rheumatoid arthritis-associated interstitial lung disease [PDF]

, 2021
Jianping Gao, Lei Xin, Qiannan Guo, Ke Xu, G Zhang, Yunxiao Yang, Daqing Ma, L Zhang   +7 more
openalex   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

QuickStats: Percentage of Traumatic Brain Injury (TBI)–Related Deaths,* by Underlying Cause and Age Group — United States, 2013 [PDF]

, 2015

openalex   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Dynamics and structure of mortality from chronic coronary artery disease among men and women in the Russian Federation in 2014-2023

Российский кардиологический журнал
Aim. To assess the dynamics of non-standardized (NSMR) and standardized mortality rates (SMR) of chronic coronary artery disease (CAD), the contribution to all-cause mortality, as well as the dynamics and structure of chronic CAD among men and women in ...
R. N. Shepel, I. V. Samorodskaya, E. P. Kakorina, O. M. Drapkina   +3 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Mortality from chronic ischaemic heart disease in the Russian Federation: are there enough data for analysis and decision-making?

Кардиоваскулярная терапия и профилактика
Aim. To discuss the role of coding the underlying cause of death based on International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10) in changing the standardized mortality rates (SMR) from various chronic ...
R. N. Shepel, I. V. Samorodskaya, E. P. Kakorina, O. M. Drapkina   +3 more
doaj   +1 more source

Peer Review #2 of "A divergence between underlying and final causes of death in selected conditions: an analysis of death registries in Peru (v0.1)"

, 2018

openalex   +1 more source

The effect of salubrinal on the endoplasmic reticulum stress pathway in heat‐stressed spermatogonial cells in vitro

FEBS Open Bio, EarlyView.
This study investigates the protective role of salubrinal against heat‐induced endoplasmic reticulum (ER) stress in mouse spermatogenic cells (GC1 and GC2). By modulating the ER stress pathway, salubrinal alleviates cellular stress and supports spermatogenic cell survival, suggesting its potential as a therapeutic candidate for heat‐related infertility.
Suna Karadeniz Saygili, Mustafa Oztatlici, Mahmut Kemal Ozbilgin   +2 more
wiley   +1 more source