Results 101 to 110 of about 138,890 (301)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Effect of gestational weight gain on pregnancy outcomes in underweight pregnant women

Thai Journal of Obstetrics and Gynaecology, 2013
Objective:To determine a relationship between inadequate gestational weight gain and adverse pregnancy outcomes among Thai gravidas with underweight. Methods: A retrospective cohort study was conducted in 306 underweight pregnant women who attended our ...
Suttanaratt Apiwantana, Ratchadawan Sooklim, Sumonmal Manusirivithaya, Chadakarn Phaloprakarn   +3 more
doaj  

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Energy imbalance gap was associated with body mass index and sex in Latin American adolescents—results from the ELANS study

Frontiers in Nutrition
IntroductionEnergy imbalance gap (EIG) is defined as the average daily difference between energy intake (EI) and energy expenditure (EE). This study aimed to examine the associations between EIG and sociodemographic and anthropometric variables in the ...
Pablo Hernandez, Marianella Herrera-Cuenca, Marianella Herrera-Cuenca, Marianella Herrera-Cuenca, Marianella Herrera-Cuenca, Gerson Ferrari, Gerson Ferrari, Rafaela Yépez Almeida, Martha Cecilia Yépez García, Mónica Villar Cáceres, Lilia Yadira Cortés Sanabria, Yaritza Sifontes, Yaritza Sifontes, Maritza Landaeta-Jimenez, Georgina Gómez, Rafael Monge-Rojas, Rossina G. Pareja, Attilio Rigotti, Irina Kovalskys, Mauro Fisberg, Mauro Fisberg   +20 more
doaj   +1 more source

Weight-for-Age Status of Selected Infants at Admission into the RUIF Program: Normal, Global Underweight and Severe Underweight.

, 2013
Weight-for-Age Status of Selected Infants at Admission into the RUIF Program: Normal, Global Underweight and Severe Underweight.
Erin Boyd (503777), Leisel E. Talley (409580)   +1 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Comparison of the WHO Child Growth Standards with the NCHS for Estimation of Malnutrition in Birjand-Iran

International Journal of Preventive Medicine, 2014
Background: Anthropometric indices are widely used to assess the health and nutritional status of children The aim of the present study was determination of malnutrition and compare estimates of under nutrition among young children under 2 years of age ...
Kokab Namakin, Gholam Reza Sharifzadeh, Mahmoud Zardast, Zeynab Khoshmohabbat, Mahsa Saboori   +4 more
doaj  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source