Results 101 to 110 of about 215,526 (316)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

A Study on Health Status of Urban School Children (7-18 Years): A School Based Cross Sectional Study

National Journal of Community Medicine, 2017
Background: School age is considered as a dynamic period of growth and development because children undergo physical, mental, emotional and social changes.
Jai P Singh, Atul Kumar Singh
doaj  

Nutritional Status of Children and its Relation to Maternal Factors: An Endeavor Toward Better-Nourished Western Rural India

Indian Journal of Community Medicine
Introduction: Malnutrition has a direct impact on infant mortality rate and under-five mortality rates, which are prime indicators of the health status of a country. COVID-19 has also substantially affected the nutritional status of children.
Krishna M. Jasani, Vibha V. Gosalia, Shobha V. Misra   +2 more
doaj   +1 more source

Using weight-for-age for predicting wasted children in Cameroon

The Pan African Medical Journal, 2013
INTRODUCTION: The equipment for taking body weights (scales) are more frequently used in Cameroon health centres than measuring boards for heights.
Georges Nguefack-Tsague, Agatha Tanya Nguti Kien, Charles Ntungwen Fokunang   +2 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

¿Los sujetos con obesidad subestiman su tamaño corporal? Una revisión narrativa de los métodos de estimación y teorías explicativas [PDF]

, 2018
The widespread of overweight and obesity in the developed countries is a real societal issue, nevertheless a considerable amount of subjects with obesity do not recognize their condition.
Granese, Valentina, Mauro Manzoni, Gian, Pietrabissa, Giada   +2 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Association between body mass index and survival after hematopoietic stem cell transplantation [PDF]

The Korean Journal of Internal Medicine
Background/Aims The unclear relationship between body mass index (BMI) and post-hematopoietic stem cell transplantation (HSCT) mortality was investigated, including the impact of metabolic diseases.
Han-Sang Baek, Jong Hyuk Lee, Joonyub Lee, Seung-Hwan Lee, Gi June Min, Sung-Soo Park, Silvia Park, Sung-Eun Lee, Byung-Sik Cho, Ki-Seong Eom, Yoo-Jin Kim, Seok Lee, Hee-Je Kim, Chang-Ki Min, Seok-Goo Cho, Jong Wook Lee, Jae-Ho Yoon   +16 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Investigation of Nutritional Status in Elementary School Students of South Khorasan Province:East of Iran

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2008
Background and Objectives Children have greater nutritional needs than adults in order to maintain their growth. It has been determined that about 70% of all malnourished children in the world live in Asia.
A Fesharakinia, Gh Sharifzadeh, A Zarban
doaj