Results 111 to 120 of about 127,482 (308)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The Association between Water, Sanitation, Hygiene, and Child Underweight in Punjab, Pakistan: An Application of Population Attributable Fraction

Muhammad Nadeem,1 Mumtaz Anwar,2 Shahid Adil,3 Wajid Syed,4 Mahmood Basil A Al-Rawi,5 Ayesha Iqbal6,7 1Department of Economics, University of Education, Lahore, Vehari Campus, Pakistan; 2School of Economics, University of the Punjab, Lahore, Pakistan ...
Nadeem M, Adil S, Syed W, Al-Rawi MBA, Iqbal A, Anwar M   +5 more
core  

Modelling under-nutrition in under-five children in Malawi

, 2013
Despite numerous Government efforts to tackle the problem of child under-nutrition in Malawi, the levels of child under-nutrition remain high with stunting estimated at 47% and underweight at 12.7% .
Chikhungu, Lana
core  

Comparison of underweight.

, 2019
Comparisons were made between the subjects in the general population and subjects with cerebral palsy at each National Health Screening Program for Infants and Children screening after the age of 1 year.
Tae Uk Kang (4630972), Hyun Jung Kim (182757), Jihyun Kim (79184), Shin-Young Yim (6087161), Kyu Yong Park (6087158), Hyeong Sik Ahn (512367)   +5 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Pregnancy underweight – an overlooked risk factor

, 2020
Underweight, defined as BMI ≤ 18.5 kg/m2, is found in 4.2% of pregnancies in Denmark. Pre-pregnancy underweight is more often seen in relation to psychiatric disorders, e.g.
Ostenfeld, Anne, Nøhr, Ellen Aagaard; id_orcid, Bjørnholt, Sarah Marie, Buskbjerg Palm, Camilla Viola; id_orcid, Ankerstjerne, Lea Bo Sønderlund ; id_orcid, Lauenborg, Jeannet, Bergenheim, Sara Johanna, Fuglsang, Jens, Renault, Kristina Martha, Rønneberg, Elisabeth Thal, Kristensen, Susanne Lund   +10 more
core   +1 more source

Underweight and pregnancy [PDF]

BJOG: An International Journal of Obstetrics & Gynaecology, 2016
openaire   +2 more sources