Results 31 to 40 of about 1,905,453 (180)

Impact of refractory and unexplained chronic cough on disease burden: a qualitative study [PDF]

BMC Pulmonary Medicine, 2022
Background Chronic cough lasting for > 8 weeks is a common medical condition that burdens patients. This study aimed to qualitatively describe knowledge, awareness, experiences, and subtypes of burdens (physical, social, psychological) among Japanese ...
Naoya Ueda, Anzu Yakushiji, Jonathan Schelfhout, Shigeru Tokita, Takekazu Kubo   +4 more
doaj   +2 more sources

Mechanisms and Rationale for Targeted Therapies in Refractory and Unexplained Chronic Cough. [PDF]

Clin Pharmacol Ther, 2021
Chronic cough, defined as a cough lasting > 8 weeks, is a common medical condition that exerts a substantial physical, mental, and social burden on patients. A subset of patients with chronic cough are troubled with a cough that persists despite optimal treatment of presumed associated common and uncommon conditions (refractory chronic cough; RCC ...
Mazzone SB, McGarvey L.
europepmc   +7 more sources

A Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Phase 2b Trial of P2X3 Receptor Antagonist Sivopixant for Refractory or Unexplained Chronic Cough. [PDF]

Lung, 2023
Introduction To determine the optimal dose of sivopixant, a highly selective P2X3 receptor antagonist, for refractory or unexplained chronic cough (RCC/UCC).
McGarvey L, Smith JA, Morice A, Birring SS, Chung KF, Dicpinigaitis PV, Niimi A, Benninger MS, Sher M, Matsunaga Y, Miyazaki S, Machida M, Ishihara H, Mahmood A, Gomez JC.   +14 more
europepmc   +2 more sources

Laryngeal Vibrotactile Stimulation Is Feasible, Acceptable To People With Unexplained Chronic Cough. [PDF]

Laryngoscope
Unexplained chronic cough (UCC) is common and has significant impacts on quality of life. Ongoing cough can sensitize the larynx, increasing the urge to cough and perpetuating the cycle of chronic cough.
Misono S, Shen EY, Sombrio AG, Lunos S, Xu J, Hoffmeister J, Stockness A, Butcher L, Weinstein D, Gaeckle NT, Gray R, Konczak J.   +11 more
europepmc   +2 more sources

Disease burden, comorbidities and antecedents of chronic cough phenotypes in Australian adults

Pulmonology
Background and objectives While adult chronic cough has high burden, its phenotypes, particularly those without aetiologically related underlying conditions, are understudied.
S. Suresh, J.L. Perret, E.H. Walters, M.J. Abramson, G. Bowatte, C. Lodge, A. Lowe, B. Erbas, P. Thomas, G.S. Hamilton, A.B. Chang, S.C. Dharmage, D.S. Bui   +12 more
doaj   +2 more sources

Efficacy and safety of pharmacotherapy for refractory or unexplained chronic cough: a systematic review and network meta-analysis. [PDF]

EClinicalMedicine, 2023
Summary Background Refractory chronic cough (RCC) has a significant impact on patient’s health-related quality of life and represents a challenge in clinical management. However, the optimal treatment for RCC remains controversial.
Zheng Z, Huang J, Xiang Z, Wu T, Lan X, Xie S, Lin Z, Tang K, Morice A, Li S, Song WJ, Chen R.   +11 more
europepmc   +2 more sources

Role of Gastroesophageal Reflux in Children With Unexplained Chronic Cough

Journal of Pediatric Gastroenterology and Nutrition, 2011
ABSTRACTObjective:The relation between respiratory symptoms and gastroesophageal reflux (GER) is a matter of contention and debate, with limited data in children to substantiate or refute cause and effect. Moreover, there are few data on the relation between nonacid reflux and chronic cough in childhood.
Osvaldo Borrelli, MARABOTTO, CATERINA, Valentina Mancini, ALOI, MARINA, MACRI', Francesco, FALCONIERI, Paola, Keith J. Lindley, CUCCHIARA, Salvatore   +7 more
openaire   +5 more sources

Gefapixant, a P2X3 Receptor Antagonist, for the Treatment of Refractory or Unexplained Chronic Cough: A Randomised, Double-Blind, Controlled, Parallel-Group, Phase 2b Trial

Lancet Respiratory Medicine,the, 2020
BACKGROUND Gefapixant is a P2X3 receptor antagonist that has shown promise for the treatment of refractory and unexplained chronic cough. The aim of this study was to evaluate the efficacy of gefapixant compared with placebo after 12 weeks of treatment ...
Jaclyn A. Smith, Alyn H Morice, Surinder S Birring   +2 more
exaly   +2 more sources

A Scoping Literature Review of Digital Measures and Patient-Reported Outcomes for Refractory/Unexplained Chronic Cough: Assessment of Clinical Trials and Real-World Clinical Practice. [PDF]

Lung
Refractory/unexplained chronic cough (RCC/UCC) is a disease associated with substantial clinical and humanistic burden. A variety of endpoints have been used in RCC/UCC research to measure cough outcomes and impact on patients’ quality of life (QoL ...
Skinner EP, Alfonso-Cristancho R, De A, Leinwand B, Duncan EA.   +4 more
europepmc   +2 more sources

Burden of Chronic Cough and Refractory/Unexplained Chronic Cough in South Korea: A Multicenter, Observational Study (CHORUS). [PDF]

Lung
Purpose Refractory or unexplained chronic cough (RUCC) represents an unmet clinical need. This study aimed to explore the components constituting the disease burden in patients with RUCC by comparing clinical features, healthcare use, and patient ...
Shim JS, Kim MH, Kang SY, Lee JH, Jo EJ, Lee BJ, Cho SH, Jang J, Song WJ.   +8 more
europepmc   +2 more sources