Results 111 to 120 of about 1,004,483 (288)

Unfolded protein response, treatment and CMT1B [PDF]

Rare Diseases, 2013
CMT1B is the second most frequent autosomal dominant inherited neuropathy and is caused by assorted mutations of the myelin protein zero (MPZ) gene. MPZ mutations cause neuropathy gain of function mechanisms that are largely independent MPZs normal role of mediating myelin compaction.
Yunhong Bai, Agnes Patzko, Michael E. Shy   +2 more
openaire   +3 more sources

Prostate cancer and the unfolded protein response

Oncotarget, 2016
The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells.
Fahri Saatcioglu, Fahri Saatcioglu, Margrethe Storm, Yke Jildouw Arnoldussen, Xia Sheng   +4 more
openaire   +6 more sources

The role of the unfolded protein response in cancer progression: From oncogenesis to chemoresistance

Biology of the Cell, 2018
Tumour cells endure both oncogenic and environmental stresses during cancer progression. Transformed cells must meet increased demands for protein and lipid production needed for rapid proliferation and must adapt to exist in an oxygen‐ and nutrient ...
Emma C. Madden, S. Logue, Sandra Healy, S. Manié, Afshin Samali   +4 more
semanticscholar   +1 more source

The unfolded protein response and Alzheimer’s disease

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2001
Disruption of calcium homeostasis, inhibition of protein glycosylation, and reduction of disulfide bonds provoke accumulation of unfolded protein in the endoplasmic reticulum (ER), and are therefore a type of 'ER stress'. Normal cells respond to ER stress by increasing transcription of genes encoding ER-resident chaperones such as GRP78/BiP, GRP94 and ...
Takunari Yoneda, Takashi Kudo, Ko Miyoshi, Kazunori Imaizumi, Taiichi Katayama, Manabu Taniguchi, Masaya Tohyama   +6 more
openaire   +3 more sources

Navigating the landscape of the unfolded protein response in CD8+ T cells

Frontiers in Immunology
Endoplasmic reticulum stress occurs due to large amounts of misfolded proteins, hypoxia, nutrient deprivation, and more. The unfolded protein is a complex intracellular signaling network designed to operate under this stress. Composed of three individual
Keith Alan Nair, Keith Alan Nair, Bei Liu, Bei Liu   +3 more
doaj   +1 more source

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections

Virulence, 2019
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR).
P. Mehrbod, Sudharsana Rao Ande, Javad Alizadeh, Shahrzad Rahimizadeh, Aryana Shariati, Hadis Malek, M. Hashemi, Kathleen K M Glover, A. Sher, K. Coombs, S. Ghavami   +10 more
semanticscholar   +1 more source

Virus-induced ER stress and the unfolded protein response

Frontiers in Plant Science, 2012
The accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER) results in ER stress that triggers cytoprotective signaling pathways, termed the unfolded protein response (UPR), to restore and maintain homeostasis in the
Lingrui eZhang, Aiming eWang
doaj   +1 more source

Proteomic study of the membrane components of signalling cascades of Botrytis cinerea controlled by phosphorylation [PDF]

, 2019
Protein phosphorylation and membrane proteins play an important role in the infection of plants by phytopathogenic fungi, given their involvement in signal transduction cascades.
Amil, Francisco, Blanco-Ulate, Barbara, Cantoral Fernández, Jesús Manuel, Carrasco, Rafael, Chiva, Cristina, Escobar Niño, Almudena, Fernández Acero, Francisco Javier, Fuentes, Carlos, Lineiro, Eva, Sabido, Eduard   +9 more
core   +2 more sources

Splicing: HACking into the unfolded-protein response [PDF]

Current Biology, 1998
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase.
openaire   +3 more sources

Signaling and Regulation of the Mitochondrial Unfolded Protein Response.

Cold Spring Harbor Perspectives in Biology, 2019
The mitochondrial proteome encompasses more than a thousand proteins, which are encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding ...
N. U. Naresh, Cole M. Haynes
semanticscholar   +1 more source