PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway
Nature Communications, 2019 Cancer cells utilise the unfolded protein response (UPR) to adapt to environmental and ER stress. Here, the authors show that the glycosidase II beta subunit, PRKSCH, protects cancer cells from ER stress, by interacting with IRE1α and activating the ...
Gu-Choul Shin +5 more
doaj +1 more source
Medicinal Research Reviews, EarlyView.ABSTRACT Autophagy is a highly conserved intracellular process involved in maintaining homeostasis and in the degradation of damaged organelles and external pathogens. Nature provides complex and varied reservoirs of scaffolds and chemical entities that may have a pivotal role in the search for new therapeutic leads.
Ilaria Cursaro +5 more
wiley +1 more source
E-cigarette aerosols induce unfolded protein response in normal human oral keratinocytes. [PDF]
, 2019 Objective: Since the introduction in 2004, global usage of e-cigarettes (ECs) has risen exponentially. However, the risks of ECs on oral health are uncertain.
Chen, Wei +9 more
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Pancreatic adaptive responses in alcohol abuse: Role of the unfolded protein response. [PDF]
, 2015 The majority of those who drink excessive amounts of alcohol do not develop pancreatic disease. One overarching hypothesis is that alcohol abuse requires additional risk factors, either environmental or genetic, for disease to occur.
Lugea, Aurelia +2 more
core +1 more source
VIEW, EarlyView.Peyronie's disease (PD) is a common male reproductive system disorder. The exact etiology of PD remains unclear. This study aimed to investigate molecular and cellular changes in PD using single‐cell spatial transcriptomics. Abstract Peyronie's disease (PD), commonly known as penile induration, is a prevalent male reproductive system disorder with ...
Keyuan Lou +6 more
wiley +1 more source
PERK and filamin A in actin cytoskeleton remodeling at ER-plasma membrane contact sites
Molecular & Cellular Oncology, 2017 The endoplasmic reticulum (ER) stress sensor protein kinase RNA-like endoplasmic reticulum kinase (PERK) plays a major role during the unfolded protein response (UPR), mainly through eIF2α phosphorylation.
Alexander R. van Vliet +1 more
doaj +1 more source
New insights into the unfolded protein response (UPR)-anterior gradient 2 (AGR2) pathway in the regulation of intestinal barrier function in weaned piglets. [PDF]
Anim Nutr, 2023 Zhang F +5 more
europepmc +1 more source
Stress in dipteran insects mass‐reared for sterile insect technique applications
Insect Science, EarlyView.The connections between biotic and abiotic stress affecting mass‐reared dipteran insects and the associated stress and immunological responses. Numbers indicate the order in which the topics are discussed in this review. Abstract Stress may be viewed as the disturbance of homeostasis of an organism.
Caroline K. Mirieri +3 more
wiley +1 more source
Immunogenic landscape and risk score prediction based on unfolded protein response (UPR)-related molecular subtypes in hepatocellular carcinoma. [PDF]
Front Immunol, 2023 Guo H +8 more
europepmc +1 more source
Messenger RNA targeting to endoplasmic reticulum stress signalling sites. [PDF]
, 2009 Deficiencies in the protein-folding capacity of the endoplasmic reticulum (ER) in all eukaryotic cells lead to ER stress and trigger the unfolded protein response (UPR).
Aragón, Tomás +6 more
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