Results 171 to 180 of about 52,959 (267)
Environmental Stressors and the Unfolded Protein Response (UPR) in Exocrine Pancreatic Function
Frontiers in Physiology, 2011 The exocrine pancreas has the greatest synthetic capacity of any mammalian organ and as such is challenged with synthesis, processing and transporting a large load of digestive enzymes. Here we discuss how both mutations in the digestive enzymes and environmental factors impacting the pancreas such as alcohol abuse, smoking, metabolic disorders and ...
Stephen J Pandol +5 more
openaire +1 more source
Advanced Science, Volume 13, Issue 7, 3 February 2026.The Phospholamban (PLN) R9C mutation reduces SERCA2a binding, increasing calcium recycling and baseline contractility. However, the excess of free PLN promotes pentamer formation, limiting phosphorylation and blunting β‐adrenergic signaling. Under cardiac stress, enhanced functional demands overwhelm proteostasis in PLN R9C cells, leading to misfolded ...
Qi Yu +10 more
wiley +1 more source
Cell Biochemistry and Function, Volume 44, Issue 2, February 2026.ABSTRACT Living beings are persistently challenged by stress. Stress can be induced by internal stressors and external stressors. External stressors, including radiation, heat, heavy metals, nutritional imbalances, infections, and psychological stress, can induce protein denaturation, leading to misfolded or aggregated proteins.
Paka Sravan Kumar +5 more
wiley +1 more source
ATF4 Mediates Mitochondrial Unfolded Protein Response (UPR mt ) in Alveolar Epithelial Cells [PDF]
, 2020 H. Cui +7 more
openalex +1 more source
Hypercapnia Effects on Lung Function
Comprehensive Physiology, Volume 16, Issue 1, February 2026.CO2 is a signaling molecule that disrupts alveolar fluid clearance and ion transport, impairs alveolar repair, and promotes mitochondrial and endoplasmic reticulum dysfunction. It suppresses innate immunity, host defense, and inflammation, while increasing airway contractility.
Seungseo Choi +2 more
wiley +1 more source
MicrobiologyOpen, Volume 15, Issue 1, February 2026.This study demonstrates that the BvrR induces neuroinflammation. In microglial cells, BvrR expression localizes to the endoplasmic reticulum (ER), causing ER expansion and activating the stress sensor IRE1. Phosphorylated IRE1 subsequently drives the activation and nuclear translocation of transcription factors ATF2 and NF‐κB p65.
Zhao Wang +3 more
wiley +1 more source
Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets
MedComm, Volume 7, Issue 2, February 2026.Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren +4 more
wiley +1 more source
Activation of the Unfolded Protein Response (UPR) Is Associated with Cholangiocellular Injury, Fibrosis and Carcinogenesis in an Experimental Model of Fibropolycystic Liver Disease. [PDF]
Cancers (Basel), 2021 Chen C +28 more
europepmc +1 more source