Results 181 to 190 of about 52,959 (267)

Is Ferroptosis the Mechanistic Bridge Connecting Iron Dysregulation to Muscle Wasting and Functional Decline in Aging?

Aging Cell, Volume 25, Issue 2, February 2026.
This work proposes ferroptosis as a mechanistic driver of age‐related muscle dysfunction, whereby iron dyshomeostasis and impaired antioxidant capacity promote lipid peroxidation, and eventually trigger ferroptosis, leading to muscle wasting, and ultimately contributing to weakness and functional decline with aging.
Rola S. Zeidan, Simon Reinhard, Anna Picca, Emanuele Marzetti, Christiaan Leeuwenburgh, James F. Collins, Stephen D. Anton   +6 more
wiley   +1 more source

ONC201 induces the unfolded protein response (UPR) in high- and low-grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity. [PDF]

Cancer Med, 2021
Rumman M, Buck S, Polin L, Dzinic S, Boerner J, Winer IS.   +5 more
europepmc   +1 more source

Gonadal function in males with WFS1 spectrum disorder (Wolfram syndrome)—A European cohort perspective

Andrology, Volume 14, Issue 2, Page 398-410, February 2026.
Abstract Background WFS1 spectrum disorder, also known as Wolfram syndrome (WS) is an ultra‐rare (<1:500,000; ORPHA: 3463) monogenic (OMIM #222300) progressive neuroendocrine and neurodegenerative disorder, characterised by early‐onset insulin‐dependent diabetes, optic atrophy, central diabetes insipidus and sensi‐neuronal deafness.
Julia Rohayem, Olivia Cunningham, Denise Williams, Joachim Wistuba, Liam McCarthy, Timothy G. Barrett, Renuka P. Dias   +6 more
wiley   +1 more source

Tumor Necrosis Factor α (TNFα) Induces the Unfolded Protein Response (UPR) in a Reactive Oxygen Species (ROS)-dependent Fashion, and the UPR Counteracts ROS Accumulation by TNFα [PDF]

, 2005
Xin Xue, Jiang‐Hu Piao, Akihito Nakajima, Sachiko Komazawa‐Sakon, Yuko Kojima, Kazutoshi Mori, Hideo Yagita∥, Ko Okumura, Heather P. Harding, Hiroyasu Nakano   +9 more
openalex   +1 more source

Emerging mechanisms of the unfolded protein response in therapeutic resistance: from chemotherapy to Immunotherapy

Cell Communication and Signaling
The accumulation of unfolded or misfolded proteins in the endoplasmic reticulum (ER) causes ER stress and activates the unfolded protein response (UPR). As an adaptive cellular response to hostile microenvironments, such as hypoxia, nutrient deprivation,
Jiang He, You Zhou, Lunquan Sun
doaj   +1 more source

The Unfolded Protein Response (UPR) in Pulmonary Fibrosis; with a Redox Twist [PDF]

D109. MODULATING THE FIBROTIC RESPONSE, 2020
V. Anathy, A. Kumar, E. Elko, S. Bruno, Z. Mark, J. Villalobos, N. Chamberlain, J. Walzer, Y.M.W. Janssen-Heininger   +8 more
openaire   +1 more source

The mitochondrial unfolded protein response (UPR^mt): shielding against toxicity to mitochondria in cancer. [PDF]

J Hematol Oncol, 2022
Inigo JR, Chandra D.
europepmc   +1 more source

Dysregulation of the unfolded protein response (UPR) in the dorsolateral prefrontal cortex in elderly patients with schizophrenia. [PDF]

Mol Psychiatry, 2021
Kim P, Scott MR, Meador-Woodruff JH.
europepmc   +1 more source

The virulence of the opportunistic fungal pathogenAspergillus fumigatusrequires cooperation between the endoplasmic reticulum-associated degradation pathway (ERAD) and the unfolded protein response (UPR) [PDF]

, 2011
Daryl L. Richie, Xizhi Feng, Lukas Hartl, Vishukumar Aimanianda, Karthik Krishnan, Margaret V. Powers‐Fletcher, Douglas S. Watson, Amit K. Galande, Stephanie M. White, Taryn Willett, Jean‐Paul Latgé, Judith C. Rhodes, David S. Askew   +12 more
openalex   +1 more source

Mammalian ECD protein is a novel negative regulator of the PERK arm of the unfolded protein response [PDF]

, 2017
Ammons, Shalis A, Band, Hamid, Band, Vimla, Bele, Aditya, Gurumurthy, C. B, Mir, Riyaz A, Mirza, Sameer, Olou, Appolinaire A, Saleem, Irfana, Sarkar, Aniruddha, Urano, Fumihiko   +10 more
core   +2 more sources