Results 221 to 230 of about 67,514 (293)

Auranofin Induces ER Stress‐Mediated Apoptosis, and Its Combination With Bortezomib Elicits Paraptosis‐Like Cell Death in Malignant Canine Mammary Tumour Cells

Veterinary and Comparative Oncology, EarlyView.
A schematic representation summarises the key findings of the study. In Auranofin (AF)‐sensitive canine mammary tumour (CMT) cells, treatment with 0.5–2 μM AF induces moderate endoplasmic reticulum (ER) stress via thioredoxin reductase (TrxR) inhibition, leading to ER stress‐mediated apoptosis.
Yoon‐Ho Suh, Se‐Hoon Kim, Ki‐Hoon Song, Jun‐Yeol Choi, Min‐Ok Ryu, Robert B. Rebhun, Kyoung‐Won Seo   +6 more
wiley   +1 more source

Mechanistic Interactions Driving Nucleus Pulposus Cell Senescence in Intervertebral Disc Degeneration: A Multi‐Axial Perspective of Mechanical, Immune, and Metabolic Pathways

JOR SPINE, Volume 8, Issue 3, September 2025.
The senescence of NPCs is at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back discomfort. ABSTRACT Background The senescence of nucleus pulposus cells (NPCs) at the heart of the pathogenesis of intervertebral disc degeneration (IVDD), which causes low back pain.
Yunbo Yang, Haoming Li, Junhui Zuo, Fei Lei   +3 more
wiley   +1 more source

Mitochondrial unfolded protein response (UPR^mt) as novel therapeutic targets for neurological disorders. [PDF]

J Cereb Blood Flow Metab
Chen X, An H, He J, Guo J, Xu S, Wu C, Wu D, Ji X.   +7 more
europepmc   +1 more source

Angiogenesis Induced By Aminoacyl-tRNA Synthetase Deficiency Is Dependent on Amino Acid Response (AAR) but Not Unfolded Protein Response (UPR) Pathways

, 2018
Fan Zhang, Yi Chen, Yi Jin, Chunhui Xu, Dian-Jia Liu, Aining Xu, Yuanliang Zhang, Yinyin Xie, Jingyi Shi, Lan Wang, Qiuhua Huang, Zhu Chen, Sai‐Juan Chen, Xiao‐Jian Sun   +13 more
openalex   +1 more source

130 Novel mechanism involving crosstalk of notch and unfolded protein response (UPR) signaling drives pathogenesis of arsenic-mediated skin neoplasm [PDF]

, 2017
C. Li, Ruchi Srivastava, Craig A. Elmets, Farrukh Afaq, Mohammad Athar   +4 more
openalex   +1 more source

Photophagy: Unveiling a Novel Cellular Mechanism in UVB‐Induced Skin Aging and Resilience

International Journal of Dermatology, EarlyView.
Sheikh A. Umar, Sheikh A. Tasduq
wiley   +1 more source

Cytokine‐Induced Cytotoxicity and Extracellular Matrix Abnormalities in Hepatocytes Derived From RAD50‐Interacting Protein 1‐Deficient Induced Pluripotent Stem Cells

The FASEB Journal, Volume 39, Issue 15, 15 August 2025.
RAD50‐interacting protein1 (RINT1) deficiency causes recurrent acute liver failure (RALF) during fever or infections. To investigate its underlying mechanism, induced pluripotent stem cells were generated from a patient with RINT1 deficiency and differentiated into hepatocyte‐like cells (HLCs). RINT1‐deficient HLCs exhibited damage resembling RALF when
Yumeng Zhang, Yoshiyasu Ogata, Satomi Nadanaka, Hiroshi Kitagawa, Takumi Era, Muneaki Matsuo   +5 more
wiley   +1 more source

Molecular Perspective of Nanoparticle Mediated Therapeutic Targeting in Breast Cancer: An Odyssey of Endoplasmic Reticulum Unfolded Protein Response (UPR^ER) and Beyond. [PDF]

Biomedicines, 2021
Rahman S, Kumar V, Kumar A, Abdullah TS, Rather IA, Jan AT.   +5 more
europepmc   +1 more source

Induction of the unfolded protein response (UPR) suppresses porcine reproductive and respiratory syndrome virus (PRRSV) replication

, 2019
Nicholas Catanzaro, Xiang‐Jin Meng
openalex   +2 more sources

Mammalian ECD protein is a novel negative regulator of the PERK arm of the unfolded protein response [PDF]

, 2017
Ammons, Shalis A, Band, Hamid, Band, Vimla, Bele, Aditya, Gurumurthy, C. B, Mir, Riyaz A, Mirza, Sameer, Olou, Appolinaire A, Saleem, Irfana, Sarkar, Aniruddha, Urano, Fumihiko   +10 more
core   +2 more sources