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The role of protein phosphatase 2A (PP2A) in the unfolded protein response (UPR) of plants
Biochemical and Biophysical Research Communications, 2023Protein phosphatase 2A (PP2A) is a key regulator of plant growth and development, but its role in the endoplasmic reticulum (ER) stress response remains elusive. In this study, we investigated the function of PP2A under ER stress using loss-of-function mutants of ROOTS CURL of NAPHTHYLPHTHALAMIC ACID1 (RCN1), a regulatory A1 subunit isoform of ...
Ki Seong Ko +10 more
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Measurement of the Unfolded Protein Response (UPR) in Monocytes
2011In mammalian cells, the primary function of the endoplasmic reticulum (ER) is to synthesize and assemble membrane and secreted proteins. As the main site of protein folding and posttranslational modification in the cell, the ER operates a highly conserved quality control system to ensure only correctly assembled proteins exit the ER and misfolded and ...
Carroll, Tomás P +2 more
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Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants
Protoplasma, 2015Being a major factory for protein synthesis, assembly, and export, the endoplasmic reticulum (ER) has a precise and robust ER quality control (ERQC) system monitoring its product line. However, when organisms are subjected to environmental stress, whether biotic or abiotic, the levels of misfolded proteins may overwhelm the ERQC system, tilting the ...
Shucen, Wan, Liwen, Jiang
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Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes
Life Sciences, 2019Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality control system for cellular proteins as it is intricately involved in their synthesis, folding and trafficking to the respective targets. Type 2 diabetes is characterized by enhanced blood glucose level that promotes insulin resistance and hampers cellular glucose ...
Vivek Kumar, Pandey +2 more
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Abstract 5663: Clinical relevance of unfolded protein response (UPR) signaling in breast cancer
Cancer Research, 2022Abstract Background: Protein homeostasis as regulated by the Endoplasmic Reticulum (ER) is a recognized process involved in cancer progression. ER stress activates the Unfolded Protein Response (UPR) and has been implicated in a variety of cancers.
Masanori Oshi +7 more
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Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection
Virology, 2018Marek's disease (MD) is a pathology of chickens associated with paralysis, immune suppression, and the rapid formation of T-cell lymphomas. MD is caused by the herpesvirus, Marek's disease virus (MDV). We examined endoplasmic reticulum (ER) stress and the activation of unfolded protein response (UPR) pathways during MDV infection of cells in culture ...
Sabari Nath, Neerukonda +4 more
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Regulating the trafficking of the unfolded protein response (UPR) reporter ATF6
2023The activating transcription factor 6 (ATF6) is one of the three membrane proteins, which responds to misfolded protein induced stress, in the endoplasmic reticulum (ER). During ER stress, ATF6 dissociates from BiP, an ER chaperone, then transports to the Golgi apparatus where ATF6 undergoes proteolytic processing by site 1 protease (S1P) and site 2 ...
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2015
Mutations in the TULP1 gene are associated with early-onset retinitis pigmentosa (RP); however, the molecular mechanisms related to the deleterious effects of TULP1 mutations remains unknown. Several studies have shown that misfolded proteins secondary to genetic mutations can accumulate within the endoplasmic reticulum (ER), causing activation of the ...
Glenn P, Lobo +3 more
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Mutations in the TULP1 gene are associated with early-onset retinitis pigmentosa (RP); however, the molecular mechanisms related to the deleterious effects of TULP1 mutations remains unknown. Several studies have shown that misfolded proteins secondary to genetic mutations can accumulate within the endoplasmic reticulum (ER), causing activation of the ...
Glenn P, Lobo +3 more
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Cutaneous Unfolded Protein Response (UPR) and Endoplasmic Reticulum (ER) Stress
2021Rather A. Rafiq +2 more
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Interaction of Inorganic Phosphate and Unfolded Protein Response (UPR) in Placenta
Placenta, 2021Ana Correia-Branco +11 more
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