Results 231 to 240 of about 67,514 (293)

Presbycusis: Pathology, Signal Pathways, and Therapeutic Strategy

Advanced Science, Volume 12, Issue 29, August 7, 2025.
In ARHL, the stria vascularis, acting as a cochlear battery, gradually loses its ability to maintain the endocochlear potential, leading to impaired hair cell function and progressive hearing loss. Single‐cell sequencing reveals age‐related cellular changes in the cochlea, providing insights into the underlying mechanisms of aging and potential ...
Xiaoxu Zhao, Tian Shen, Shengda Cao, Ziyi Liu, Wendu Pang, Meixuan Li, Jingjing Liu, Wen Li, Yunhao Wu, Chengcheng Liu, Ming Xia, Xiaolong Fu, Cheng Cheng   +12 more
wiley   +1 more source

The Impact of Exercise Capacity on Complex Neuromuscular Adaptations: A Narrative Review Based on a Rat Model System Selectively Bred for Low and High Response to Training

Comprehensive Physiology, Volume 15, Issue 4, August 2025.
Integrative cellular signaling triggered by the impaired glucose tolerance or impaired insulin sensitivity, mitochondrial dysfunction, mediated by an intricate cellular signaling orchestrated by TGF‐ß1‐JNK and TNF‐α‐MAPK increased extracellular matrix (ECM) remodeling pathways, and loss of type I muscle fibers in LRT models. Adapted from Lessard et al.
Vinicius Guzzoni, Upasana Shrestha, Nicholas J. Kesler, Aditya Acharya, Samantha J. McKee, Tatiana Sousa Cunha, Dulce Elena Casarini, Steven T. Haller, David J. Kennedy, Steven L. Britton, Lauren Gerard Koch   +10 more
wiley   +1 more source

A repurposed drug combination (VaN) inhibits free light chain secretion and triggers the terminal unfolded protein response (UPR) in multiple myeloma (MM)

, 2023
Jiang Y, Down JM, Maynard S, Jenkins S, Ferritti L, Beke F, Al-Hazmi B, Southam AD, Kvist J, Mirbahai L, Besse L, Bunce CM, Drayson MT, Lawson MA, Khanim F.   +14 more
europepmc   +1 more source

Spatial Organisation of Tumour cDC1 States Correlates with Effector and Stem‐Like CD8+ T Cells Location

European Journal of Immunology, Volume 55, Issue 8, August 2025.
Using scRNAseq and spatial analysis, we analyse cDC1 states and spatial distribution in tumours during immune‐mediated rejection. We identify two cDC1 activation states, each occupying different regions and associated with distinct CD8+ T cell populations.
Cécile Piot, Mariana Pereira da Costa, Adi Biram, Carlos M. Minutti, Kok Haw Jonathan Lim, Mary Green, Ania Mikolajczak, Robert P. Jenkins, Lucy Meader, Michael D. Buck, Ana Cardoso, Neil Rogers, Erik Sahai, Caetano Reis e Sousa   +13 more
wiley   +1 more source

Exosomes, autophagy, and cancer: A complex triad

International Journal of Cancer, Volume 157, Issue 3, Page 405-415, 1 August 2025.
Abstract Cancer remains one of the leading causes of death worldwide. Despite remarkable progress in prevention, diagnosis, and therapy, the incidence of certain types of cancer persists, urging the identification of clinically relevant biomarkers and the development of novel therapeutic strategies to improve clinical outcomes and overcome treatment ...
María Guerra‐Andrés, Álvaro F. Fernández, Tania Fontanil   +2 more
wiley   +1 more source

Investigation of endoplasmic reticulum stress parameters in patients with gestational diabetes mellitus: A prospective study

International Journal of Gynecology &Obstetrics, Volume 170, Issue 2, Page 774-782, August 2025.
Abstract Objective Our aim in this study was to evaluate the levels of Activating Transcription Factor‐6 (ATF‐6), Inositol‐Requiring Enzyme 1 (IRE‐1), and C/EBP‐Homologous Protein (CHOP), which are critical markers of endoplasmic reticulum (ER) stress, in patients with gestational diabetes mellitus (GDM), a condition increasingly recognized for its ...
Sevcan Sarıkaya, Eissa Almaghrebi, Fatma Akat, Eda Nur Hepbildi, Esra Kosucu, Muslu Kazım Körez, Husamettin Vatansev   +6 more
wiley   +1 more source

Mitochondrial unfolded protein response (UPR^mt): what we know thus far. [PDF]

Front Cell Dev Biol
Torres AK, Fleischhart V, Inestrosa NC.
europepmc   +1 more source

Long‐Term High‐Fat Diet Affected Bone Marrow Microenvironment During Aging at Single‐Cell Resolution

MedComm, Volume 6, Issue 8, August 2025.
High‐fat diet (HFD) promotes obesity and degenerative diseases. We established a long‐term HFD to aging (LHA) mouse model, finding it induces a bone marrow shift from osteogenesis to adipogenesis and abnormal immune cell metabolic adaptations. Signaling axes were identified through single‐cell RNA sequencing as potential bone marrow‐brain crosstalk ...
Yidan Pang, Siyuan Zhu, Peng Ding, Senyao Zhang, Yi Zhang, Fang Ye, Changqing Zhang, Junjie Gao, Jimin Yin   +8 more
wiley   +1 more source

Neuroprotective Potential of the Flavonoids Quercetin and Epicatechin in a C. elegans Tauopathy Model

Molecular Nutrition &Food Research, Volume 69, Issue 15, August 2025.
Epicatechin and quercetin enhanced healthspan in the C. elegans BR5270 tauopathy model, associated with the upregulation of autophagy‐related and α‐tubulin synthesis genes, and the downregulation of genes involved in the unfolded protein response. ABSTRACT The prevalence of cognitive disorders such as Alzheimer's disease (AD) is increasing due to the ...
Lidia Garzón‐García, Begoña Ayuda‐Durán, Susana González‐Manzano, Celestino Santos‐Buelga, Ana M. González‐Paramás   +4 more
wiley   +1 more source

Metformin modulates the unfolded protein responses, altering lifespan and health-promoting effects in UPR-activated worms

Jun Tan, Chutipong Chiamkunakorn, Kanpapat Boonchuay, Yufang Shi, Bart P. Braeckman, Wichit Suthammarak   +5 more
openalex   +1 more source