Results 261 to 270 of about 67,514 (293)

Endoplasmic Reticulum Stress and Unfolded Protein Response Sensor ERN1 Regulates Organic Dust Induction of Lung Inflammation. [PDF]

FASEB Bioadv
Kusampudi S, Meganathan V, Boggaram V.
europepmc   +1 more source

ER stress-driven unfolded protein response fuels aging-related tumor aggressiveness in gliomas. [PDF]

Front Mol Biosci
Shao X, Guo S, Yang J, Dai J, Cao K, Cai X, Song T, Yao S, Raza U, Chen K.   +9 more
europepmc   +1 more source

Impact of ER stress and the unfolded protein response on Fabry disease. [PDF]

EBioMedicine
Lenders M, Rudolph E, Brand E.
europepmc   +1 more source

Targeting of the unfolded protein response (UPR) as therapy for Parkinson's disease

Biology of the Cell, 2019
Parkinson's disease is the second most common neurodegenerative disorder, leading to the progressive decline of motor control due to the loss of dopaminergic neurons in the substantia nigra pars compacta. At the molecular level, Parkinson's disease share
Alexis Martínez, N. López, Constanza Gonzalez, C. Hetz   +3 more
semanticscholar   +5 more sources

The stress rheostat: an interplay between the unfolded protein response (UPR) and autophagy in neurodegeneration.

Current Molecular Medicine, 2008
The unfolded protein response (UPR) is a conserved adaptive reaction that increases cell survival under conditions of endoplasmic reticulum (ER) stress. The UPR controls diverse processes such as protein folding, secretion, ER biogenesis, protein quality
S. Matus, Fernanda Lisbona, Mauricio Torres, Cristian León, P. Thielen, C. Hetz   +5 more
semanticscholar   +8 more sources

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XBP-1 and the unfolded protein response (UPR)

Nature Immunology, 2020
Laurie Glimcher and colleagues recount their work that showed how the transcription factor XBP1 and the UPR signaling pathway are interconnected during plasma cell differentiation.
L. Glimcher, Ann-Hwee Lee, N. Iwakoshi
semanticscholar   +4 more sources

Endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) in plants

Protoplasma, 2016
Being a major factory for protein synthesis, assembly, and export, the endoplasmic reticulum (ER) has a precise and robust ER quality control (ERQC) system monitoring its product line. However, when organisms are subjected to environmental stress, whether biotic or abiotic, the levels of misfolded proteins may overwhelm the ERQC system, tilting the ...
Shucen Wan, Liwen Jiang
semanticscholar   +4 more sources

Role of the unfolded protein response (UPR) in cataract formation.

Experimental Eye Research, 2006
Cataract is a multifactorial disease, and a large variety of stressors induce cataracts. Many cataractogenic stressors and endoplasmic reticulum (ER) stressors induce the unfolded protein response (UPR) in various cell types. The UPR is known to produce reactive oxygen species (ROS) prior to the inducement of apoptosis.
K. Ikesugi, R. Yamamoto, M. Mulhern, T. Shinohara   +3 more
semanticscholar   +4 more sources

What's unique? - The unfolded protein response (UPR) in plants.

Journal of Experimental Botany, 2021
The investigation of a phenomenon called the unfolded protein response (UPR) started approximately 3 decades ago, and we now know that the UPR is involved in a number of cellular events among metazoans, higher plants, and algae.
Chao-Yuan Yu, Yueh Cho, Oshin Sharma, K. Kanehara   +3 more
semanticscholar   +1 more source