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The role of protein phosphatase 2A (PP2A) in the unfolded protein response (UPR) of plants
Biochemical and Biophysical Research Communications, 2023Protein phosphatase 2A (PP2A) is a key regulator of plant growth and development, but its role in the endoplasmic reticulum (ER) stress response remains elusive. In this study, we investigated the function of PP2A under ER stress using loss-of-function mutants of ROOTS CURL of NAPHTHYLPHTHALAMIC ACID1 (RCN1), a regulatory A1 subunit isoform of ...
Ki Seong Ko +10 more
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The unfolded protein response (UPR) pathway: the unsung hero in breast cancer management
Apoptosis, 2022Tumor cells always have the need to produce an increased amount of proteins in the cells. This elevated amount of proteins increases the pressure on the organelles of the cell such as the endoplasmic reticulum and compels it to increase its protein folding efficiency. However, it is by a matter of fact, that the amount of proteins synthesized outweighs
Arunita, Patra +2 more
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Induction of the unfolded protein response (UPR) during pseudorabies virus infection
Veterinary Microbiology, 2019Pseudorabies virus (PRV) infection causes great economic losses in the pig industry. By disrupting the homeostasis of the endoplasmic reticulum (ER), many viral infections induce ER stress and trigger the unfolded protein response (UPR). However, the roles of ER stress and UPR in PRV infection remain unclear.
Jingjing Zhu +5 more
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Unfolded protein response (UPR) mediated under heat stress in plants
Plant Physiology Reports, 2020Drastic fluctuation in temperature during crop growth challenges its yield to a greater extent, thus diminishing the agricultural productivity globally. At the cellular level, protein homeostasis is altered or disturbed directly or indirectly by the high temperature.
M. K. Malini +4 more
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The mammalian unfolded protein response.
Annual Review of Biochemistry, 2003In the endoplasmic reticulum (ER), secretory and transmembrane proteins fold into their native conformation and undergo posttranslational modifications important for their activity and structure.
M. Schröder, R. Kaufman
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Reproduction, Fertility and Development, 2023
Context Proliferation, differentiation, migration and apoptosis of trophoblastic cells are influenced by hypoxia, as well as adequate modulation of oxidative stress and the unfolded protein response (UPR) pathway. Aims We aimed to evaluate the expression profile of redox and UPR mediators in the placenta of rats throughout pregnancy ...
Jeane Martinha dos Anjos Cordeiro +9 more
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Context Proliferation, differentiation, migration and apoptosis of trophoblastic cells are influenced by hypoxia, as well as adequate modulation of oxidative stress and the unfolded protein response (UPR) pathway. Aims We aimed to evaluate the expression profile of redox and UPR mediators in the placenta of rats throughout pregnancy ...
Jeane Martinha dos Anjos Cordeiro +9 more
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Emerging role of Unfolded Protein Response (UPR) mediated proteotoxic apoptosis in diabetes
Life Sciences, 2019Endoplasmic reticulum (ER) is a crucial single membrane organelle that acts as a quality control system for cellular proteins as it is intricately involved in their synthesis, folding and trafficking to the respective targets. Type 2 diabetes is characterized by enhanced blood glucose level that promotes insulin resistance and hampers cellular glucose ...
Alpana Mathur +3 more
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Regulating the trafficking of the unfolded protein response (UPR) reporter ATF6
2023The activating transcription factor 6 (ATF6) is one of the three membrane proteins, which responds to misfolded protein induced stress, in the endoplasmic reticulum (ER). During ER stress, ATF6 dissociates from BiP, an ER chaperone, then transports to the Golgi apparatus where ATF6 undergoes proteolytic processing by site 1 protease (S1P) and site 2 ...
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Induction of the unfolded protein response (UPR) during Marek's disease virus (MDV) infection
Virology, 2018Marek's disease (MD) is a pathology of chickens associated with paralysis, immune suppression, and the rapid formation of T-cell lymphomas. MD is caused by the herpesvirus, Marek's disease virus (MDV). We examined endoplasmic reticulum (ER) stress and the activation of unfolded protein response (UPR) pathways during MDV infection of cells in culture ...
Upendra K. Katneni +4 more
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Ricin-A-chain (RTA) inhibits the unfolded protein response (UPR) in mammalian cells [PDF]
, 2010 Ricin, a type II ribosome-inactivating protein, has been used as a biochemical weapon due to its ability to inhibit protein synthesis and induce cytotoxicity. The unfolded protein response (UPR) is a survival response that helps cells to recover from stress that occurs following the accumulation of misfolded proteins in the ER.
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