Results 91 to 100 of about 378,452 (270)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Electro-gravity entanglement [PDF]

Kragujevac Journal of Science
One fundamental question is the connection between electrical and gravitational forces. We present a quantum entanglement model, with multiple discrete electrically charged wave-packets, that simulates gravitational attraction among them, where quantum ...
Moreno Jose C.
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Using mechanisms of object-oriented programming for the unification of procedures of work with the monthly plan and for manufacture and shipment of the main production

Литьë и металлургия, 2019
This article describes a version of the modernization of the software (SOFTWARE), which allows to create monthly production plans and shipping program for shops of the main production, which used some of the mechanisms of object-oriented programming. The
N. P. Papkov, E. S. Onegina
doaj   +1 more source

Strong Coupling Running, Gauge Coupling Unification and the Scale of New Physics

, 2015
The apparent unification of gauge couplings in Grand Unified Theories around 10$^{16}$ GeV is one of the strong arguments in favor of Supersymmetric extensions of the Standard Model.
Bourilkov, Dimitri
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Cold Dark Matter and b --> s gamma in the Horava-Witten Theory

, 2001
The minimal supersymmetric standard model with complete, partial or no Yukawa unification and radiative electroweak breaking with boundary conditions from the Horava-Witten theory is considered.
Adel, Aldazabal, Aldazabal, Ali, Ali, Ali, Ali, Barate, Barbieri, Bertolini, Borzumati, Borzumati, C. Pallis, Carena, Cerdeño, Chetyrkin, Ciafaloni, Ciuchini, Ciuchini, Czarnecki, Drees, Ellis, Ellis, Ellis, G. Lazarides, Gondolo, Greub, Greub, Griest, Gómez, Gómez, Heinemeyer, Hořava, Hořava, Kagan, Khalil, Kobayashi, Lahanas, Lazarides, Lukas, Martı́ i Gracı́a, Mizuta, Nilles, Panagiotakopoulos, Pierce, S. Khalil, Witten   +46 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Preserving the Integrity of Organizations’ Quality Management System during Unification and Integration: Functional Approach

Вестник Кемеровского государственного университета. Серия: политические, социологические и экономические науки, 2023
The article addresses the problems of preserving the integrity of quality management systems during integration of educational organizations into a single educational complex.
Marina V. Sokolovskaya, Elena V. Zamiralova   +1 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source