Results 101 to 110 of about 365,376 (221)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Women, identity and employment in East Germany [PDF]

, 2003
This book chapter was reproduced with the kind permission of Continuum books.This book chapter discusses Marxist feminism and female employment in the GDR, current attitudes to employment amongst East German women, and pre-unification versus post ...
Wagener, Debbie
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Ujednačavanje pomorskog prava i interesi Hrvatske

Poredbeno Pomorsko Pravo, 2004
Republika Hrvatska, kao pomorska država, ima osobit interes pratiti unifikacijske težnje u uređenju pomorskopravnih odnosa. Hrvatska je poglavito dužna ratificirati i primjenjivati konvencije i dogovore iz područja sigurnosti plovidbe, njihove česte ...
Ivo Grabovac
doaj  

Aspectos institucionais da unificação das polícias no Brasil

Dados: Revista de Ciências Sociais, 2004
Dans cet article, on examine l'unification des polices militaire et civile brésiliennes en cherchant les références empiriques dans des études précédentes réalisées au sujet des polices des États de São Paulo, Minas Gerais et Rio de Janeiro.
Mateus Afonso Medeiros
doaj   +1 more source

Towards the Non-Chiral Extension of SM and MSSM

, 1996
We show that in some SU(N) type GUTs with the complementary pairs of the conjugated fermion multiplets there naturally appear the relatively light ($M\ll M_{GUT}$) vectorlike fermions which considerably modify the desert physics.
A.B. Kobakhidze, Abachi, Abe, Abreu, Akrawy, Amaldi, Antonadis, Bagger, Barbieri, Chamseddine, Chkareuli, Chkareuli, Chkareuli, Dienis, Dimopoulos, Frampton, Frampton, Fritzsch, Georgi, Georgi, Georgi, I.G. Gogoladze, J.L. Chkareuli, Jones, Li, Peccei, Shifman, Sikivie   +27 more
core   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Difference unification

, 1992
We extend previous work on difference identification and reduction as a technique for automated reasoning. We generalize unification so that terms are made equal not only by finding substitutions for variables but also by hiding term structure. This annotation of structural differences serves to direct rippling, a kind of rewriting designed to remove ...
Basin, D., Walsh, T.
openaire   +2 more sources

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source